PEPTIDE NUCLEIC ACID PROBE FOR MULTIPLEX DETECTION OF BCR/ABL NEGATIVE MYELOPROLIFERATIVE NEOPLASM-ASSOCIATED GENE MUTATIONS, COMPOSITION FOR MULTIPLEX DETECTION OF GENE MUTATIONS, CONTAINING SAME, MULTIPLEX DETECTION KIT, AND METHOD FOR MULTIPLEX DETECTION OF GENE MUTATIONS - THE CATHOLIC UNIV OF KOREA INDUSTRY-ACADEMIC COOP FOUND

Title:

PEPTIDE NUCLEIC ACID PROBE FOR MULTIPLEX DETECTION OF BCR/ABL NEGATIVE MYELOPROLIFERATIVE NEOPLASM-ASSOCIATED GENE MUTATIONS, COMPOSITION FOR MULTIPLEX DETECTION OF GENE MUTATIONS, CONTAINING SAME, MULTIPLEX DETECTION KIT, AND METHOD FOR MULTIPLEX DETECTION OF GENE MUTATIONS

Document Type and Number:

WIPO Patent Application WO/2017/082503

Kind Code:

A1

Abstract:

The present invention provides: a peptide nucleic acid probe comprising any one or more selected from the group consisting of base sequences represented by SEQ ID NOs: 7-10 and base sequences complementary to the base sequences, and manufactured so as to complementarily bind to a BCR/ABL negative myeloproliferative neoplasm-associated gene, thereby enabling multiplex detection of gene mutations; a composition for multiplex detection of gene mutations, containing the same; a kit; and a method for multiplex detection of BCR/ABL negative myeloproliferative neoplasm-associated gene mutations, using the same. Therefore, since multiplex detection of BCR/ABL negative myeloproliferative neoplasm-associated gene mutations can be rapidly and accurately carried out by one detection process, BCR/ABL negative myeloproliferative neoplasm is effectively diagnosed, and thus the present invention can be useful for diagnosis, follow-up, prognosis estimation and treatment of diseases.

Inventors:

KIM YONG-GOO (KR)
KIM MYUNG-SHIN (KR)
PARK JOON-HONG (KR)
SONG MIN-SIK (KR)
PARK HEE-KYUNG (KR)
KIM KYUNG-TAK (KR)

Application Number:

PCT/KR2016/005927

Publication Date:

May 18, 2017

Filing Date:

June 03, 2016

Export Citation:

Click for automatic bibliography generation Help

Assignee:

THE CATHOLIC UNIV OF KOREA INDUSTRY-ACADEMIC COOP FOUND (KR)
SEASUNBIO MAT (KR)

International Classes:

C12Q1/68

Domestic Patent References:

WO2015036599A1

2015-03-19

Foreign References:

JP2015070808A	2015-04-16
CN1932038A	2007-03-21
KR20140091944A	2014-07-23
KR20120068992A	2012-06-27

Other References:

KIM, B. H. ET AL.: "JAK2 V617F, MPL, and CALR Mutations in Korean Patients with Essential Thrombocythemia and Primary Myelofibrosis", JOURNAL OF KOREAN MEDICAL SCIENCE, vol. 30, no. 7, pages 882 - 888, XP055381457

Attorney, Agent or Firm:

WIE, Byoung-Gap (KR)

Download PDF:

View/Download PDF PDF Help

Previous Patent: DISPLAY DEVICE

Next Patent: APPARATUS FOR MANUFACTURING COAL BRIQUETTE