Title:
AΒ PEPTIDE OXIDANT
Document Type and Number:
WIPO Patent Application WO/2014/200091
Kind Code:
A1
Abstract:
Provided are an agent for inhibiting the aggregation and an agent for lowering the toxicity of Aβ peptide, as well as an agent for the prevention and treatment of Alzheimer's disease. An Aβ oxidant that oxidizes one or more amino acid residues that constitute Aβ peptide (excluding an Aβ oxidant that oxidizes only Met).
Inventors:
KANAI MOTOMU (JP)
SOMA YOHEI (JP)
TANIGUCHI ATSUHIKO (JP)
SASAKI DAISUKE (JP)
SOMA YOHEI (JP)
TANIGUCHI ATSUHIKO (JP)
SASAKI DAISUKE (JP)
Application Number:
PCT/JP2014/065749
Publication Date:
December 18, 2014
Filing Date:
June 13, 2014
Export Citation:
Assignee:
JAPAN SCIENCE & TECH AGENCY (JP)
International Classes:
C07K14/47; A61K38/00; A61K45/00; A61P25/28
Foreign References:
| JP2012503012A | 2012-02-02 |
Other References:
CHRISTIAN SCHONEICH: "Selective Cu2+/Ascorbate- Dependent Oxidation of Alzheimer's Disease beta- Amyloid Peptides", ANNALS NEW YORK ACADEMY OF SCIENCE, vol. 1012, 2004, pages 164 - 170, XP055301717
KOICHI INOUE ET AL.: "Liquid chromatography/ tandem mass spectrometry characterization of oxidized amyloid beta peptides as potential biomakers of Alzheimer's disease", RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 20, 2006, pages 911 - 918, XP055301722
SERGIO GIUNTA ET AL.: "Transformation of beta- amyloid (Abeta) (1-42) tyrosine to L-Dopa sa the result of in vitro hydroxyl radical attack", AMYLOID: INT. J. EXP. CLIN. INVEST., vol. 7, 2000, pages 189 - 193, XP008181685
ATSUHIKO TANIGUCHI ET AL.: "Attenuation of the Aggregation and Neurotoxicity of Amyloid-beta Peptides by Catalytic Photooxygenation", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 53, no. 5, 27 January 2014 (2014-01-27), pages 1382 - 1385, XP055301732
J. HARDY; D. J. SELKOE, SCIENCE, vol. 297, 2002, pages 353
S. A. GRAVINA ET AL., J. BIOL. CHEM., vol. 270, 1995, pages 7013
HOU, L. ET AL., J. BIOL. CHEM., vol. 277, no. 43, 2002, pages 40173 - 40176
BITAN, G. ET AL., J. AM. CHEM. SOC., vol. 125, no. 50, 2003, pages 15359 - 15365
MOSKOVITZ, J. ET AL., BIOCHEMISTRY, vol. 50, 2011, pages 10687 - 10697
PATTISON, D. I.; RAHMANTO, A. S.; DAVIES, M. J.: "Photo-oxidation of proteins", PHOTOCHEM. PHOTOBIOL. SCI., vol. 11, 2012, pages 38 - 53
SCHEY, K. L.; FINLEY, E. L.: "Identification of peptide oxidation by tandem mass spectrometry", ACC. CHEM. RES., vol. 33, 2000, pages 299 - 306
See also references of EP 3009446A4
KOICHI INOUE ET AL.: "Liquid chromatography/ tandem mass spectrometry characterization of oxidized amyloid beta peptides as potential biomakers of Alzheimer's disease", RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 20, 2006, pages 911 - 918, XP055301722
SERGIO GIUNTA ET AL.: "Transformation of beta- amyloid (Abeta) (1-42) tyrosine to L-Dopa sa the result of in vitro hydroxyl radical attack", AMYLOID: INT. J. EXP. CLIN. INVEST., vol. 7, 2000, pages 189 - 193, XP008181685
ATSUHIKO TANIGUCHI ET AL.: "Attenuation of the Aggregation and Neurotoxicity of Amyloid-beta Peptides by Catalytic Photooxygenation", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 53, no. 5, 27 January 2014 (2014-01-27), pages 1382 - 1385, XP055301732
J. HARDY; D. J. SELKOE, SCIENCE, vol. 297, 2002, pages 353
S. A. GRAVINA ET AL., J. BIOL. CHEM., vol. 270, 1995, pages 7013
HOU, L. ET AL., J. BIOL. CHEM., vol. 277, no. 43, 2002, pages 40173 - 40176
BITAN, G. ET AL., J. AM. CHEM. SOC., vol. 125, no. 50, 2003, pages 15359 - 15365
MOSKOVITZ, J. ET AL., BIOCHEMISTRY, vol. 50, 2011, pages 10687 - 10697
PATTISON, D. I.; RAHMANTO, A. S.; DAVIES, M. J.: "Photo-oxidation of proteins", PHOTOCHEM. PHOTOBIOL. SCI., vol. 11, 2012, pages 38 - 53
SCHEY, K. L.; FINLEY, E. L.: "Identification of peptide oxidation by tandem mass spectrometry", ACC. CHEM. RES., vol. 33, 2000, pages 299 - 306
See also references of EP 3009446A4
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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