Title:
PEPTIDE, POLYNUCLEOTIDE, VECTOR, TRANSFORMANT, NFκB INHIBITOR, AND THERAPEUTIC AGENT FOR DISEASES ASSOCIATED WITH ACCELERATED NFκB ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2016/098838
Kind Code:
A1
Abstract:
This peptide has an NFκB inhibitory effect and is any one of the following peptides: (a) a peptide comprising any amino acid sequence from SEQ ID NOs: 1-5; (b) a peptide having an NFκB inhibitory effect and comprising any amino acid sequence from SEQ ID NOs: 1-5, wherein one or a plurality of amino acid residues having been replaced, deleted and/or added; (c) a peptide having an NFκB inhibitory effect and comprising an amino acid sequence that is at least 80% homologous with any amino acid sequence from SEQ ID NOs: 1-5; (d) a peptide in which a cell-penetrating peptide is fused with any peptide selected from (a)-(c); and (e) a peptide in which a Met residue, a MetAla residue or an Ala residue is added to the N terminal of any peptide selected from (a)-(d).
Inventors:
OKAMOTO KAZUKI (JP)
Application Number:
PCT/JP2015/085286
Publication Date:
June 23, 2016
Filing Date:
December 16, 2015
Export Citation:
Assignee:
UNIV SCHOOL ST MARIANNA (JP)
International Classes:
C12N15/09; A61K38/00; A61K48/00; A61P29/00; C07K14/47; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Foreign References:
| JP4874798B2 | 2012-02-15 |
Other References:
KAZUKI OKAMOTO ET AL.: "NF-KB Sogaiyaku", INFLAMMATION & IMMUNOLOGY, vol. 21, no. 3, 2013, pages 229 - 233
KAZUKI OKAMOTO ET AL.: "(4T13a-04) Atarashii Type no Kakunai Receptor·Coactivator (MTI-II) o Riyo shita NF-KB Sogaiyaku no Kaihatsu", THE JAPANESE BIOCHEMICAL SOCIETY DAI 87 KAI ANNUAL MEETING OF THE JAPANESE BIOCHEMICAL SOCIETY YOSHISHU, 1 October 2014 (2014-10-01), pages 445, 3P-006
KAZUKI OKAMOTO ET AL.: "(4T13a-04) Atarashii Type no Kakunai Receptor·Coactivator (MTI-II) o Riyo shita NF-KB Sogaiyaku no Kaihatsu", THE JAPANESE BIOCHEMICAL SOCIETY DAI 87 KAI ANNUAL MEETING OF THE JAPANESE BIOCHEMICAL SOCIETY YOSHISHU, 1 October 2014 (2014-10-01), pages 445, 3P-006
Attorney, Agent or Firm:
Taiyo, Nakajima & Kato (JP)
Patent business corporation solar international patent firm (JP)
Patent business corporation solar international patent firm (JP)
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