Title:
PEPTIDE PRODUCTION METHOD, PROTECTING GROUP REMOVING METHOD, REMOVING AGENT, AND BENZYL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/127331
Kind Code:
A1
Abstract:
One problem to be addressed by the present invention is to provide: a protecting group removing method capable of suppressing generation of double-hit bodies and diketopiperazine, easily scavenging a fulvene backbone-including compound that is a by-product potentially generated after deprotecting a protecting group having a fluorine backbone, and easily isolating a scavenged body of the by-product; a peptide production method comprising a step for removing a protecting group; and a protecting group removing agent. A peptide production method according to one aspect of the present invention comprises: a step for bringing, in an organic solvent, a scavenger represented by formula (Z1) into contact with an amino group-containing compound in which the N-terminal is protected by a protecting group having a fluorine backbone, to obtain a scavenged body in which the scavenger is bound to a by-product having a fulvene backbone derived from the protecting group; and a step for separating the obtained scavenged body from the organic solvent.
Inventors:
KASAI SOUKOU (JP)
SHIMODA YASUSHI (JP)
SATO MAKOTO (JP)
UEHARA ANRI (JP)
MATSUURA KEISUKE (JP)
SHIMODA YASUSHI (JP)
SATO MAKOTO (JP)
UEHARA ANRI (JP)
MATSUURA KEISUKE (JP)
Application Number:
PCT/JP2022/042265
Publication Date:
July 06, 2023
Filing Date:
November 14, 2022
Export Citation:
Assignee:
TOKUYAMA CORP (JP)
International Classes:
C07K1/06; C07C43/23; C07K1/02
Domestic Patent References:
| WO2016140232A1 | 2016-09-09 | |||
| WO2009014177A1 | 2009-01-29 | |||
| WO2009113511A1 | 2009-09-17 | |||
| WO2012029794A1 | 2012-03-08 |
Foreign References:
| JP6703668B2 | 2020-06-03 | |||
| JP2009529544A | 2009-08-20 | |||
| JP2021501769A | 2021-01-21 | |||
| JP2010116336A | 2010-05-27 | |||
| JP2009040726A | 2009-02-26 | |||
| CN103936960A | 2014-07-23 | |||
| JP2014074020A | 2014-04-24 |
Other References:
OKADA YOUHEI, KAZUHIRO CHIBA : "Liquid-phase peptide synthesis using hydrophobic tags and its application ", CHEMISTRY AND BIOLOGY, vol. 56, no. 8, 20 July 2018 (2018-07-20), pages 558 - 565, XP093076742, DOI: 10.1271/kagakutoseibutsu.56.558
TAN QIAN, LIAO JUNQIU, CHEN SHENG, ZHU YA, ZHANG HAILIANG: "Mesogen-jacketed liquid crystalline polymers with peripheral oligo(ethylene oxide) chains: phase structure and thermoresponsive behavior", POLYMER CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, CAMBRIDGE, vol. 5, no. 17, 1 January 2014 (2014-01-01), Cambridge , pages 5147 - 5159, XP093076743, ISSN: 1759-9954, DOI: 10.1039/C4PY00371C
AN TAE HYUN, LA YUNJU, CHO ARAH, JEONG MOON GON, SHIN TAE JOO, PARK CHIYOUNG, KIM KYOUNG TAEK: "Solution Self-Assembly of Block Copolymers Containing a Branched Hydrophilic Block into Inverse Bicontinuous Cubic Mesophases", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 9, no. 3, 24 March 2015 (2015-03-24), US , pages 3084 - 3096, XP093076744, ISSN: 1936-0851, DOI: 10.1021/nn507338s
TAN QIAN, LIAO JUNQIU, CHEN SHENG, ZHU YA, ZHANG HAILIANG: "Mesogen-jacketed liquid crystalline polymers with peripheral oligo(ethylene oxide) chains: phase structure and thermoresponsive behavior", POLYMER CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, CAMBRIDGE, vol. 5, no. 17, 1 January 2014 (2014-01-01), Cambridge , pages 5147 - 5159, XP093076743, ISSN: 1759-9954, DOI: 10.1039/C4PY00371C
AN TAE HYUN, LA YUNJU, CHO ARAH, JEONG MOON GON, SHIN TAE JOO, PARK CHIYOUNG, KIM KYOUNG TAEK: "Solution Self-Assembly of Block Copolymers Containing a Branched Hydrophilic Block into Inverse Bicontinuous Cubic Mesophases", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 9, no. 3, 24 March 2015 (2015-03-24), US , pages 3084 - 3096, XP093076744, ISSN: 1936-0851, DOI: 10.1021/nn507338s
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (JP)
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