Title:
PEPTIDE FOR PROMOTING OSTEOANAGENESIS OR OSTEOGENESIS AND USE OF SAME
Document Type and Number:
WIPO Patent Application WO/2018/038582
Kind Code:
A1
Abstract:
The present application discloses a peptide for promoting osteoanagenesis or osteogenesis, and a composition including same. The peptide or the composition including the same according to the present application has osteoanagenesis and osteogenesis functions in heterogenous bones and allogenic bones and promotes osteogenesis in a generation process too. In addition, the peptide or the composition does not exhibit heterotropic ossification. Accordingly, the composition including the peptide according to the present application can be applied to treatments of various diseases requiring osteoanagenesis and osteogenesis functions. Moreover, the peptide according to the present application can ensure safety by replacing BMP-2 or by being used with small quantities of BMP-2.
Inventors:
YOON WON JOON (KR)
Application Number:
PCT/KR2017/009373
Publication Date:
March 01, 2018
Filing Date:
August 28, 2017
Export Citation:
Assignee:
YOON WON JOON (KR)
International Classes:
A61K38/08; C07K7/06; A61K38/10; C07K7/08
Domestic Patent References:
| WO2016098936A1 | 2016-06-23 | |||
| WO2009151288A2 | 2009-12-17 | |||
| WO2016153256A1 | 2016-09-29 | |||
| WO2009093240A2 | 2009-07-30 | |||
| WO2009012175A1 | 2009-01-22 |
Foreign References:
| US4554101A | 1985-11-19 |
Other References:
MIYAMOTO, SAYAKA ET AL.: "Bombyx Mori Silk Fibroin Scaffolds for Bone Regeneration Studied by Bone Differentiation Experiment", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 115, no. 5, 1 January 2013 (2013-01-01), pages 575 - 578, XP055582023
DATABASE protein 26 July 2016 (2016-07-26), "fibroin heavy chain, partial [Bombyx mori]", XP055316480, Database accession no. ABE77387.1
ASAKURA, TETSUO ET AL.: "Synthesis and Characterization of Water-soluble Silk Peptides and Recombinant Silk Protein Containing Polyalanine, the Integrin Binding Site, and Two Glutamic Acids at Each Terminal Site as a Possible Candidate for Use in Bone Repair Materials", BIOMACROMOLECULES, vol. 14, 4 September 2013 (2013-09-04), pages 3731 - 3741, XP055582026
DIMITRIOU ET AL., BMC MEDICINE, vol. 9, 2011, pages 66
CREIGHTON: "Proteins", 1984
HENIKOFF, S.; HENIKOFF, J.G.: "Amino Acid Substitution Matrices from Protein Blocks", PNAS, vol. 89, no. 22, 1992, pages 10915 - 10919, XP002599751, DOI: doi:10.1073/pnas.89.22.10915
H. NEURATH; R.L.HILL: "The Proteins", 1979, ACADEMIC PRESS
SMITH; WATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
NEEDLEMAN; WUNSCH, J. MOL. BIO., vol. 48, 1970, pages 443
PEARSON; LIPMAN, METHODS IN MOL. BIOL., vol. 24, 1988, pages 307 - 31
HIGGINS; SHARP, GENE, vol. 73, 1988, pages 237 - 44
HIGGINS; SHARP, CABIOS, vol. 5, 1989, pages 151 - 3
CORPET ET AL., NUC. ACIDS RES., vol. 16, 1988, pages 10881 - 90
HUANG ET AL., COMP. APPL. BIOSCI., vol. 8, 1992, pages 155 - 65
PEARSON ET AL., METH. MOL. BIOL., vol. 24, 1994, pages 307 - 31
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
"Remington's Pharmaceutical Scinece", MACK PUBLISHING COMPANY
KEVIN ET AL., ADV DRUG DELIV REV., vol. 64, 2012, pages 1277 - 1291
LEE ET AL., BIOMATERIALS, vol. 32, 2011, pages 9696 - 9706
See also references of EP 3505529A4
DATABASE protein 26 July 2016 (2016-07-26), "fibroin heavy chain, partial [Bombyx mori]", XP055316480, Database accession no. ABE77387.1
ASAKURA, TETSUO ET AL.: "Synthesis and Characterization of Water-soluble Silk Peptides and Recombinant Silk Protein Containing Polyalanine, the Integrin Binding Site, and Two Glutamic Acids at Each Terminal Site as a Possible Candidate for Use in Bone Repair Materials", BIOMACROMOLECULES, vol. 14, 4 September 2013 (2013-09-04), pages 3731 - 3741, XP055582026
DIMITRIOU ET AL., BMC MEDICINE, vol. 9, 2011, pages 66
CREIGHTON: "Proteins", 1984
HENIKOFF, S.; HENIKOFF, J.G.: "Amino Acid Substitution Matrices from Protein Blocks", PNAS, vol. 89, no. 22, 1992, pages 10915 - 10919, XP002599751, DOI: doi:10.1073/pnas.89.22.10915
H. NEURATH; R.L.HILL: "The Proteins", 1979, ACADEMIC PRESS
SMITH; WATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
NEEDLEMAN; WUNSCH, J. MOL. BIO., vol. 48, 1970, pages 443
PEARSON; LIPMAN, METHODS IN MOL. BIOL., vol. 24, 1988, pages 307 - 31
HIGGINS; SHARP, GENE, vol. 73, 1988, pages 237 - 44
HIGGINS; SHARP, CABIOS, vol. 5, 1989, pages 151 - 3
CORPET ET AL., NUC. ACIDS RES., vol. 16, 1988, pages 10881 - 90
HUANG ET AL., COMP. APPL. BIOSCI., vol. 8, 1992, pages 155 - 65
PEARSON ET AL., METH. MOL. BIOL., vol. 24, 1994, pages 307 - 31
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
"Remington's Pharmaceutical Scinece", MACK PUBLISHING COMPANY
KEVIN ET AL., ADV DRUG DELIV REV., vol. 64, 2012, pages 1277 - 1291
LEE ET AL., BIOMATERIALS, vol. 32, 2011, pages 9696 - 9706
See also references of EP 3505529A4
Attorney, Agent or Firm:
PARK, Weonmee (KR)
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