Title:
PEPTIDE SEQUENCE FOR MODULATION OF DELTA PROTEIN KINASE C
Document Type and Number:
WIPO Patent Application WO2006017578
Kind Code:
A3
Abstract:
A peptide identified from the annexin V protein sequence and having the ability to modulate the activity of delta protein kinase C (PKC) is described. The peptide and variants thereof bind to delta PKC and are effective to regulate delta PKC mediated cellular responses. In particular the annexin V peptide is able to inhibit protein-protein interaction with delta PKC, blocking intracellular translocation of delta PKC. Inhibition of delta PKC translocation confers protection to tissue at risk of exposure to ischemia or hypoxia or to reperfusion injury.
Inventors:
MOCHLY-ROSEN DARIA (US)
KHEIFETS VIKTORIA (US)
SCHECHTMAN DEBORAH (BR)
INAGAKI KOICHI (JP)
KIHARA YASUKI (JP)
KHEIFETS VIKTORIA (US)
SCHECHTMAN DEBORAH (BR)
INAGAKI KOICHI (JP)
KIHARA YASUKI (JP)
Application Number:
PCT/US2005/027567
Publication Date:
May 11, 2006
Filing Date:
August 02, 2005
Export Citation:
Assignee:
UNIV LELAND STANFORD JUNIOR (US)
MOCHLY-ROSEN DARIA (US)
KHEIFETS VIKTORIA (US)
SCHECHTMAN DEBORAH (BR)
INAGAKI KOICHI (JP)
KIHARA YASUKI (JP)
MOCHLY-ROSEN DARIA (US)
KHEIFETS VIKTORIA (US)
SCHECHTMAN DEBORAH (BR)
INAGAKI KOICHI (JP)
KIHARA YASUKI (JP)
International Classes:
C12N9/12; A61K38/00; C07K7/06
Domestic Patent References:
| WO2002057413A2 | 2002-07-25 |
Other References:
SCHECHTMAN D ET AL: "ISOZYME-SPECIFIC INHIBITORS AND ACTIVATORS OF PROTEIN KINASE C", METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC, SAN DIEGO, CA, US, vol. 345, 2002, pages 470 - 489, XP001148022, ISSN: 0076-6879
KHEIFETS VIKTORIA ET AL: "Mechanism of interaction between Annexin V and delta PKC", FASEB JOURNAL, vol. 18, no. 8, Suppl. S, May 2004 (2004-05-01), & ANNUAL MEETING OF THE AMERICAN-SOCIETY-FOR-BIOCHEMISTRY-AND-MOLECULAR BIOLOGY/8TH CONGRESS OF THE IN; BOSTON, MA, USA; JUNE 12 -16, 2004, pages C213, XP009060680, ISSN: 0892-6638
INAGAKI KOICHI ET AL: "Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 108, no. 19, 11 November 2003 (2003-11-11), pages 2304 - 2307, XP002307971, ISSN: 0009-7322
KHEIFETS VIKTORIA ET AL: "Mechanism of interaction between Annexin V and delta PKC", FASEB JOURNAL, vol. 18, no. 8, Suppl. S, May 2004 (2004-05-01), & ANNUAL MEETING OF THE AMERICAN-SOCIETY-FOR-BIOCHEMISTRY-AND-MOLECULAR BIOLOGY/8TH CONGRESS OF THE IN; BOSTON, MA, USA; JUNE 12 -16, 2004, pages C213, XP009060680, ISSN: 0892-6638
INAGAKI KOICHI ET AL: "Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 108, no. 19, 11 November 2003 (2003-11-11), pages 2304 - 2307, XP002307971, ISSN: 0009-7322
Download PDF: