Title:
PEPTIDE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/147117
Kind Code:
A1
Abstract:
Disclosed are: a peptide comprising the same or substantially the same amino acid sequence as the amino acid sequence depicted in SEQ ID NO: 1, or a salt thereof; an antibacterial agent comprising the peptide or a salt thereof; and a method for screening a prophylactic or therapeutic agent for immune diseases, urinary diseases, digestive diseases or respiratory diseases, which is characterized by using the peptide or a salt thereof and (b) a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence depicted in SEQ ID NO: 3 or a salt thereof. The antibacterial agent, the prophylactic or therapeutic agent for immune diseases, urinary diseases, digestive diseases or respiratory diseases and the like are excellent.
Inventors:
NAGI TOSHIMI (JP)
OSAKI TSUKASA (JP)
SASAKI KAZUKI (JP)
MINAMINO NAOTO (JP)
OSAKI TSUKASA (JP)
SASAKI KAZUKI (JP)
MINAMINO NAOTO (JP)
Application Number:
PCT/JP2010/060136
Publication Date:
December 23, 2010
Filing Date:
June 15, 2010
Export Citation:
Assignee:
TAKEDA PHARMACEUTICAL (JP)
NAT CEREBRAL & CARDIOVASCULAR CT (JP)
NAGI TOSHIMI (JP)
OSAKI TSUKASA (JP)
SASAKI KAZUKI (JP)
MINAMINO NAOTO (JP)
NAT CEREBRAL & CARDIOVASCULAR CT (JP)
NAGI TOSHIMI (JP)
OSAKI TSUKASA (JP)
SASAKI KAZUKI (JP)
MINAMINO NAOTO (JP)
International Classes:
C07K14/47; A61K39/395; A61P1/00; A61P11/00; A61P13/00; A61P31/04; A61P37/00; C07K14/475; C07K16/22; C12Q1/02; G01N33/15; G01N33/50; G01N33/53; A61K38/00
Other References:
BRAMANI, S. ET AL.: "Amino acids within the extracellular matrix (ECM) binding region (201-218) of rat insulin-like growth factor binding protein (IGFBP)-5 are important determinants in binding IGF-I.", J. MOL. ENDOCRINOL., vol. 23, 1999, pages 117 - 123, XP002990402, DOI: doi:10.1677/jme.0.0230117
FOWLKES, J. L. ET AL.: "Heparin-Binding, Highly Basic Regions within the Thyroglobulin Type-1 Repeat of Insulin-Like Growth Factor (IGF)-Binding Proteins (IGFBPs) -3, -5, and -6 Inhibit IGFBP-4 Degradation.", ENDOCRINOLOGY, vol. 138, 1997, pages 2280 - 2285
CAMPBELL, P. G. ET AL.: "Insulin- like growth factor (IGF)-binding protein-5- (201-218) region regulates hydroxyapatite and IGF-I binding.", AM. J. PHYSIOL. ENDOCRINOL. METAB., vol. 273, 1997, pages E1005 - E1013
CAMPBELL, P. G. ET AL.: "Plasmin degradation of insulin-like growth factor- binding protein-5 (IGFBP-5): regulation by IGFBP-5-(201-218).", AM. J. PHYSIOL. ENDOCRINOL. METAB., vol. 273, 1997, pages E996 - E1004
ANDRESS, D. L. ET AL.: "Insulin-like growth factor-binding protein-5 (IGFBP-5) stimulates phosphorylation of the IGFBP-5 receptor.", AM. J. PHYSIOL. ENDOCRINOL. METAB., vol. 274, 1998, pages E744 - E750
TWIGG, S. M. ET AL.: "Insulin-like Growth Factor-binding Protein 5 Complexes with the Acid-labile Subunit.", J. BIOL. CHEM., vol. 273, no. 44, 1998, pages 28791 - 28798, XP002340744, DOI: doi:10.1074/jbc.273.44.28791
MALIK, L. ET AL.: "Discovery of non- peptidergic MrgXl and MrgX2 receptor agonists and exploration of an initial SAR using solid-phase synthesis.", BIOORG. MED. CHEM. LETT., vol. 19, January 2009 (2009-01-01), pages 1729 - 1732, XP026005867, DOI: doi:10.1016/j.bmcl.2009.01.085
ZHENG, B. ET AL.: "Insulin-Like Growth Factor-Binding Protein-5 Is Cleaved by Physiological Concentrations of Thrombin.", ENDOCRINOLOGY, vol. 139, 1998, pages 1708 - 1714, XP002388527
FOWLKES, J. L. ET AL.: "Heparin-Binding, Highly Basic Regions within the Thyroglobulin Type-1 Repeat of Insulin-Like Growth Factor (IGF)-Binding Proteins (IGFBPs) -3, -5, and -6 Inhibit IGFBP-4 Degradation.", ENDOCRINOLOGY, vol. 138, 1997, pages 2280 - 2285
CAMPBELL, P. G. ET AL.: "Insulin- like growth factor (IGF)-binding protein-5- (201-218) region regulates hydroxyapatite and IGF-I binding.", AM. J. PHYSIOL. ENDOCRINOL. METAB., vol. 273, 1997, pages E1005 - E1013
CAMPBELL, P. G. ET AL.: "Plasmin degradation of insulin-like growth factor- binding protein-5 (IGFBP-5): regulation by IGFBP-5-(201-218).", AM. J. PHYSIOL. ENDOCRINOL. METAB., vol. 273, 1997, pages E996 - E1004
ANDRESS, D. L. ET AL.: "Insulin-like growth factor-binding protein-5 (IGFBP-5) stimulates phosphorylation of the IGFBP-5 receptor.", AM. J. PHYSIOL. ENDOCRINOL. METAB., vol. 274, 1998, pages E744 - E750
TWIGG, S. M. ET AL.: "Insulin-like Growth Factor-binding Protein 5 Complexes with the Acid-labile Subunit.", J. BIOL. CHEM., vol. 273, no. 44, 1998, pages 28791 - 28798, XP002340744, DOI: doi:10.1074/jbc.273.44.28791
MALIK, L. ET AL.: "Discovery of non- peptidergic MrgXl and MrgX2 receptor agonists and exploration of an initial SAR using solid-phase synthesis.", BIOORG. MED. CHEM. LETT., vol. 19, January 2009 (2009-01-01), pages 1729 - 1732, XP026005867, DOI: doi:10.1016/j.bmcl.2009.01.085
ZHENG, B. ET AL.: "Insulin-Like Growth Factor-Binding Protein-5 Is Cleaved by Physiological Concentrations of Thrombin.", ENDOCRINOLOGY, vol. 139, 1998, pages 1708 - 1714, XP002388527
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
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