Title:
PEPTIDE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/195504
Kind Code:
A1
Abstract:
A peptide that has an amino acid sequence represented by general formula (I) and collects in cancer-related fibroblasts. (In general formula (I), X11 represents a peptide residue having the following amino acid sequence (a) or (b). (a) An amino acid sequence represented by any of SEQ ID NOS: 1 to 4, and (b) an amino acid sequence derived from an amino acid sequence represented by any of SEQ ID NOS: 1 to 4 by deletion, substitution or addition of one or two amino acids. Y11 represents a peptide linker consisting of 1-10, inclusive, amino acid residues, said amino acid residues being independently a glycine residue, a proline residue, a serine residue, a cysteine residue or a lysine residue. X12 represents a peptide residue having the aforesaid amino acid sequence (a) or (b), or a retroinverso peptide residue thereof. n11 is an integer of 0-9 inclusive.) [Formula 1]
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Inventors:
KONDO EISAKU (JP)
SAITO KEN (JP)
SAITO KEN (JP)
Application Number:
PCT/JP2020/007917
Publication Date:
October 01, 2020
Filing Date:
February 27, 2020
Export Citation:
Assignee:
UNIV NIIGATA (JP)
International Classes:
A61K45/00; A61K47/36; A61K47/42; A61K49/00; A61K51/04; A61K51/08; A61P35/00; C07K14/00; C12N15/11; C12N15/87
Domestic Patent References:
| WO2017086090A1 | 2017-05-26 | |||
| WO2018034356A1 | 2018-02-22 | |||
| WO2017086090A1 | 2017-05-26 |
Foreign References:
| JP2019057966A | 2019-04-11 | |||
| JPS5721140B2 | 1982-05-06 |
Other References:
VIVES E. ET AL.: "A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus", J. BIOL. CHEM., vol. 272, 1997, pages 16010 - 16017, XP002940007, DOI: 10.1074/jbc.272.25.16010
PRATT, J M. ET AL., TRANSCRIPTION AND TRANSLATION - A PRACTICAL APPROACH, 1984, pages 179 - 209
SAITO K ET AL.: "Stromal mesenchymal stem cells facilitate pancreatic cancer progression by regulating specific secretory molecules through mutual cellular interaction", JOURNAL OF CANCER, vol. 9, no. 16, 2018, pages 2916 - 2929
See also references of EP 3949995A4
PRATT, J M. ET AL., TRANSCRIPTION AND TRANSLATION - A PRACTICAL APPROACH, 1984, pages 179 - 209
SAITO K ET AL.: "Stromal mesenchymal stem cells facilitate pancreatic cancer progression by regulating specific secretory molecules through mutual cellular interaction", JOURNAL OF CANCER, vol. 9, no. 16, 2018, pages 2916 - 2929
See also references of EP 3949995A4
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
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