Title:
PEPTIDE VACCINE USING MIMIC MOLECULE OF AMYLOID β-PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2009/054537
Kind Code:
A1
Abstract:
In the invention, a peptide capable of inducing production of an antibody specific to abnormal amyloid β-peptide is found from mimic peptides of amyloid β-peptide and the resulting peptide is used as a vaccine or an immunogen. The invention relates to a pharmaceutical composition comprising a peptide having 8 to 30 amino acid residues containing at least one amino acid sequence of an amino acid sequence represented by the following formula (I): Tyr-Gly-Thr-Lys-Pro-Trp-Met (I) and an amino acid sequence represented by the following formula (II): Leu-Asp-Ile-Phe-Ala-Pro-Ile (II) or a conjugate of the peptide and a carrier.
Inventors:
SUGIMURA KAZUHISA (JP)
Application Number:
PCT/JP2008/069586
Publication Date:
April 30, 2009
Filing Date:
October 22, 2008
Export Citation:
Assignee:
UNIV KAGOSHIMA (JP)
SUGIMURA KAZUHISA (JP)
SUGIMURA KAZUHISA (JP)
International Classes:
A61K39/00; A61P25/28; A61P43/00; C07K14/47
Domestic Patent References:
| WO2006005706A2 | 2006-01-19 | |||
| WO2006005707A2 | 2006-01-19 | |||
| WO2005105998A1 | 2005-11-10 | |||
| WO2005033311A2 | 2005-04-14 | |||
| WO2005105998A1 | 2005-11-10 | |||
| WO2006121656A2 | 2006-11-16 |
Foreign References:
| JP2006515876A | 2006-06-08 | |||
| JP2004520261A | 2004-07-08 | |||
| JP2006515876A | 2006-06-08 |
Other References:
GG KINNEY ET AL.: "A Novel anti-amyloid beta active vaccine approach for the treatment of Arzheimer's and related disorders", NEURO-DEGENERATIVE DISEASES, vol. 4, no. 1, 2007, pages 251
M. MANDLER ET AL., THE AFFIR IS MIMOTOPE VACCINE: A NOVEL APPROACH FOR THE TREATMENT OF AD, NEURO-DEGENERATIVE DISEASES, vol. 4, no. 1, 2007, pages 250
W. M. PARDRIDGE: "Vector-mediated drug delivery to the brain", ADVANCED DRUG DELIVERY REVIEWS, vol. 36, 1999, pages 299 - 321
W. M. PARDRIDGE: "Drug and gene targeting to the brain with molecular trojan horses", NATURE REVIEWSL DRUG DISCOVERY, vol. 1, 2002, pages 131 - 139
R B. MERIFIELD, ADVANCE IN ENZYMOLOGY, vol. 32, 1969, pages 221 - 296
KAJI ET AL., J. BIOCHEM., vol. 129, 2001, pages 577 - 583
S. HASHIGUCHI ET AL., J. BIOCHEM., vol. 133, 2003, pages 43 - 49
HASHIGUCHI ET AL., J. BIOCHEM., vol. 133, 2003, pages 43 - 49
P. JARVER; ULO LANGEL: "The use of cell-penetrating peptides as a tool for gene regulation", DDT, vol. 9, 2004, pages 395 - 401
P. JARVER; ULO LANGEL: "The use of cell-penetrating peptides as a tool for gene regulation", DDT, vol. 9, 2004, pages 395 - 402
See also references of EP 2226081A4
M. MANDLER ET AL., THE AFFIR IS MIMOTOPE VACCINE: A NOVEL APPROACH FOR THE TREATMENT OF AD, NEURO-DEGENERATIVE DISEASES, vol. 4, no. 1, 2007, pages 250
W. M. PARDRIDGE: "Vector-mediated drug delivery to the brain", ADVANCED DRUG DELIVERY REVIEWS, vol. 36, 1999, pages 299 - 321
W. M. PARDRIDGE: "Drug and gene targeting to the brain with molecular trojan horses", NATURE REVIEWSL DRUG DISCOVERY, vol. 1, 2002, pages 131 - 139
R B. MERIFIELD, ADVANCE IN ENZYMOLOGY, vol. 32, 1969, pages 221 - 296
KAJI ET AL., J. BIOCHEM., vol. 129, 2001, pages 577 - 583
S. HASHIGUCHI ET AL., J. BIOCHEM., vol. 133, 2003, pages 43 - 49
HASHIGUCHI ET AL., J. BIOCHEM., vol. 133, 2003, pages 43 - 49
P. JARVER; ULO LANGEL: "The use of cell-penetrating peptides as a tool for gene regulation", DDT, vol. 9, 2004, pages 395 - 401
P. JARVER; ULO LANGEL: "The use of cell-penetrating peptides as a tool for gene regulation", DDT, vol. 9, 2004, pages 395 - 402
See also references of EP 2226081A4
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (3-20 Toranomon 4-chome,Minato-k, Tokyo 01, JP)
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