Title:
A PEPTIDE WITH ABILITY TO PENETRATE CELL MEMBRANE
Document Type and Number:
WIPO Patent Application WO/2017/176076
Kind Code:
A1
Abstract:
The present invention relates to a novel, translationally controlled tumor protein derived-protein transduction domain (TCTP-PTD) having the ability to penetrate the cell membrane, and to the use thereof. The TCTP-PTD peptide of the present invention is capable of improving the ability of a target substance to penetrate the cell membrane to thereby effectively deliver the target substance into a living body, including cells, tissue and blood. Thus, the TCTP-PTD peptide may be used for research purposes in vitro, and may be used for clinical purposes, including treatment of various diseases, delivery of contrast agents, etc., and may also be used for diagnostic purposes and in cosmetic applications.
Inventors:
LEE KYUNG LIM (KR)
BAE HEA DUK (KR)
MAENG JEE HYE (KR)
BAE HEA DUK (KR)
MAENG JEE HYE (KR)
Application Number:
PCT/KR2017/003790
Publication Date:
October 12, 2017
Filing Date:
April 06, 2017
Export Citation:
Assignee:
EWHA UNIV - IND COLLABORATION FOUND (KR)
International Classes:
C07K7/06; A61K38/22; A61K38/26; A61K39/00; A61K47/50; C07K4/00; C07K14/575; C07K14/605
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Foreign References:
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| KR20150130249A | 2015-11-23 | |||
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| US20130136752A1 | 2013-05-30 | |||
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Other References:
LEE ET AL.: "Neuroprotective effect of Cu, Zn-superoxide dismutase fused to a TCTP-derived protein transduction domain", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 666, 2011, pages 87 - 92, XP055430549
See also references of EP 3440096A4
MORRIS ET AL., NAT. BIOTECHNOL., vol. 19, 2001, pages 1173 - 1176
JARVER ET AL., DRUG DISCOV. TODAY, vol. 9, 2004, pages 395 - 402
BIOCHEM BIOPHYS ACTA, vol. 170, 1989, pages 1007
RUBINS ET AL., MICROBIAL PATHOGENESIS, vol. 25, pages 337 - 342
ROBBINSKAWAKAMI, CURRENT OPINIONS IN IMMUNOLOGY, vol. 8, 1996, pages 628 - 636
VAN DEN EYNDE ET AL., INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH, 1997
CORREALE ET AL., JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 89, 1997, pages 293
P. NELSONLU GANC. FERGUSONP. MOSSR. GELINASL. HOODK. WAND: "Molecular cloning and charac-terisation of prostase, an androgen-regulated serine protease with prostate restricted expression", PROC. NATL. ACAD. SCI. USA, vol. 96, 1999, pages 3114 - 3119
LEINUNG MATTHEW C: "Grasso Patricia, [d-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, augments the effects of orally delivered exenatide and pramlintide acetate on energy balance and glycemic control in insulin-resistant male C57BLK/6-m db/db mice", REGULATORY PEPTIDES, vol. 179, no. 1-3, pages 33,38p
See also references of EP 3440096A4
MORRIS ET AL., NAT. BIOTECHNOL., vol. 19, 2001, pages 1173 - 1176
JARVER ET AL., DRUG DISCOV. TODAY, vol. 9, 2004, pages 395 - 402
BIOCHEM BIOPHYS ACTA, vol. 170, 1989, pages 1007
RUBINS ET AL., MICROBIAL PATHOGENESIS, vol. 25, pages 337 - 342
ROBBINSKAWAKAMI, CURRENT OPINIONS IN IMMUNOLOGY, vol. 8, 1996, pages 628 - 636
VAN DEN EYNDE ET AL., INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH, 1997
CORREALE ET AL., JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 89, 1997, pages 293
P. NELSONLU GANC. FERGUSONP. MOSSR. GELINASL. HOODK. WAND: "Molecular cloning and charac-terisation of prostase, an androgen-regulated serine protease with prostate restricted expression", PROC. NATL. ACAD. SCI. USA, vol. 96, 1999, pages 3114 - 3119
LEINUNG MATTHEW C: "Grasso Patricia, [d-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, augments the effects of orally delivered exenatide and pramlintide acetate on energy balance and glycemic control in insulin-resistant male C57BLK/6-m db/db mice", REGULATORY PEPTIDES, vol. 179, no. 1-3, pages 33,38p
Attorney, Agent or Firm:
AHN, So Young (KR)
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