Title:
PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2014/111840
Kind Code:
A3
Abstract:
There is provided a peptide which is capable of binding to an MHC molecule in vitro and being presented to a T cell without antigen processing (i.e. an apitope) which peptide comprises a portion of the region 40-60 of myelin oligodendrocyte glycoprotein (MOG). In particular there is provided an apitope which is selected from the following myelin oligodendrocyte glycoprotein peptides: MOG 41-55, 43-57, 44-58 and 45-59. There is also provided the use of such a peptide in a pharmaceutical composition and a method to treat and/or prevent a disease using such a peptide.
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Inventors:
WRAITH DAVID (GB)
STREETER HEATHER (GB)
STREETER HEATHER (GB)
Application Number:
PCT/IB2014/058233
Publication Date:
October 30, 2014
Filing Date:
January 13, 2014
Export Citation:
Assignee:
APITOPE INT NV (BE)
MERCK SERONO SA (CH)
MERCK SERONO SA (CH)
International Classes:
C07K14/705
Domestic Patent References:
| WO1997035879A1 | 1997-10-02 | |||
| WO2007131210A2 | 2007-11-15 |
Other References:
JUDITH M GREER ET AL: "Correlation of Blood T Cell and Antibody Reactivity to Myelin Proteins with HLA Type and Lesion Localization in Multiple Sclerosis", THE JOURNAL OF IMMUNOLOGY, 1 May 2008 (2008-05-01), United States, pages 6402 - 6410, XP055105294, Retrieved from the Internet [retrieved on 20140304]
MELANIE D. LEECH ET AL: "Recognition of a High Affinity MHC Class I-Restricted Epitope of Myelin Oligodendrocyte Glycoprotein by CD8+ T Cells Derived from Autoantigen-Deficient Mice", FRONTIERS IN IMMUNOLOGY, vol. 2, 24 May 2011 (2011-05-24), XP055105291, DOI: 10.3389/fimmu.2011.00017
MELANIE D. LEECH ET AL: "Recognition of a High Affinity MHC Class I-Restricted Epitope of Myelin Oligodendrocyte Glycoprotein by CD8+ T Cells Derived from Autoantigen-Deficient Mice", FRONTIERS IN IMMUNOLOGY, vol. 2, 24 May 2011 (2011-05-24), XP055105291, DOI: 10.3389/fimmu.2011.00017
Attorney, Agent or Firm:
HOLLIDAY, Louise (120 Holborn, London EC1N 2DY, GB)
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