Title:
PEPTIDES AS NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS
Document Type and Number:
WIPO Patent Application WO2002008244
Kind Code:
A3
Abstract:
The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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Inventors:
SAKSENA ANIL K
GIRIJAVALLABHAN VIYYOOR MOOPIL
LOVEY RAYMOND G
JAO EDWIN E
GIRIJAVALLABHAN VIYYOOR MOOPIL
LOVEY RAYMOND G
JAO EDWIN E
Application Number:
PCT/US2001/022678
Publication Date:
June 19, 2003
Filing Date:
July 19, 2001
Export Citation:
Assignee:
SCHERING CORP (US)
CORVAS INT INC (US)
CORVAS INT INC (US)
International Classes:
A61K45/00; A61K31/7056; A61K38/00; A61K38/08; A61K38/21; A61P31/14; A61P43/00; C07K5/02; C07K5/08; C07K5/087; C07K7/02; (IPC1-7): C07K5/062; C07K5/065; A61K38/05; A61P31/14
Domestic Patent References:
| WO2001074768A2 | 2001-10-11 | |||
| WO2001040262A1 | 2001-06-07 | |||
| WO2000052032A1 | 2000-09-08 | |||
| WO1999007734A2 | 1999-02-18 | |||
| WO1998017679A1 | 1998-04-30 |
Other References:
HAN WEI ET AL: "alpha-Ketoamides, alpha-ketoesters and alpha-diketones as HCV NS3 protease inhibitors.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, no. 8, 17 April 2000 (2000-04-17), pages 711 - 713, XP002199468, ISSN: 0960-894X
LLINAS-BRUNET MONTSE ET AL: "Studies on the c-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 8, no. 19, 6 October 1998 (1998-10-06), pages 2719 - 2724, XP002199470, ISSN: 0960-894X
LLINAS-BRUNET MONTSE ET AL: "Studies on the c-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 8, no. 19, 6 October 1998 (1998-10-06), pages 2719 - 2724, XP002199470, ISSN: 0960-894X
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