PEPTIDES DERIVED FROM ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN (ASPM) AND COMPLEXES COMPRISING SUCH PEPTIDES BOUND TO MHC MOLECULES

Title:

PEPTIDES DERIVED FROM ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN (ASPM) AND COMPLEXES COMPRISING SUCH PEPTIDES BOUND TO MHC MOLECULES

Document Type and Number:

WIPO Patent Application WO/2017/089781

Kind Code:

A3

Abstract:

The present invention relates to novel peptides derived from Abnormal spindle-like microcephaly-associated protein (ASPM), complexes comprising such peptides bound to recombinant MHC molecules, and cells presenting said peptide in complex with MHC molecules. Also provided by the present invention are binding moieties that bind to the peptides and/or complexes of the invention. Such moieties are useful for the development of immunotherapeutic reagents for the treatment of diseases such as cancer.

Inventors:

POWLESLAND ALEX (GB)
CHESTER FIONA (GB)

Application Number:

PCT/GB2016/053663

Publication Date:

August 17, 2017

Filing Date:

November 23, 2016

Export Citation:

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Assignee:

IMMUNOCORE LTD (GB)
ADAPTIMMUNE LTD (GB)

International Classes:

C07K14/47; A61K39/00; C07K4/12

Domestic Patent References:

WO2011119484A1	2011-09-29
WO2007133702A2	2007-11-22
WO2013143026A1	2013-10-03

Foreign References:

US20070061916A1	2007-03-15
US20110229524A1	2011-09-22