Title:
PEPTIDES DERIVED FROM CADHERIN AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO2003087136
Kind Code:
A3
Abstract:
The present invention provides polypeptides and peptides derived from cadherin. The polypeptides and peptides are useful in a method of inhibiting amyloid deposition and a method of inhibiting tumor metastasis. A method of determining susceptibility to Alzheimer's disease and a method of screening for agents that modify cadherin processing are also provided.
Inventors:
ROBAKIS NIKOLAOS (US)
MARAMBAUD PHILIPPE (US)
GEORGAKOPOULOS ANASTASIOS (US)
MARAMBAUD PHILIPPE (US)
GEORGAKOPOULOS ANASTASIOS (US)
Application Number:
PCT/US2003/011359
Publication Date:
December 09, 2004
Filing Date:
April 10, 2003
Export Citation:
Assignee:
SINAI SCHOOL MEDICINE (US)
ROBAKIS NIKOLAOS (US)
MARAMBAUD PHILIPPE (US)
GEORGAKOPOULOS ANASTASIOS (US)
ROBAKIS NIKOLAOS (US)
MARAMBAUD PHILIPPE (US)
GEORGAKOPOULOS ANASTASIOS (US)
International Classes:
C07K14/47; C07K14/705; (IPC1-7): A61K38/00
Other References:
BAKI ET AL: "Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex", PNAS, vol. 98, no. 5, 27 February 2001 (2001-02-27), pages 2381 - 2386, XP002982140
STROOPER ET AL: "Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein", NATURE, vol. 391, 22 January 1998 (1998-01-22), pages 387 - 390, XP001010557
STROOPER ET AL: "Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein", NATURE, vol. 391, 22 January 1998 (1998-01-22), pages 387 - 390, XP001010557
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