Title:
PEPTIDES DESIGNED TO SWITCH FOLDED STATE UPON BINDING METALS
Document Type and Number:
WIPO Patent Application WO2006051313
Kind Code:
A3
Abstract:
A peptide having sequence and structural duality that can reversibly switch between a first structural form and a second structural form in response to an agent, wherein the peptide comprises interactive motifs that interact to form a bond in response to the agent and thereby cause the peptide to assume the second structural form, wherein the second structural form includes an agent binding site.
Inventors:
WOOLFSON DEREK (GB)
CERASOLI ELEONORA (GB)
CERASOLI ELEONORA (GB)
Application Number:
PCT/GB2005/004360
Publication Date:
July 27, 2006
Filing Date:
November 14, 2005
Export Citation:
Assignee:
UNIV SUSSEX (GB)
WOOLFSON DEREK (GB)
CERASOLI ELEONORA (GB)
WOOLFSON DEREK (GB)
CERASOLI ELEONORA (GB)
International Classes:
C07K1/113; C07K14/00
Domestic Patent References:
| WO2004020464A2 | 2004-03-11 | |||
| WO2001021646A1 | 2001-03-29 |
Other References:
M J PANDYA ET AL.: "Sequence and structural duality: designing peptides to adopt two stable conformations", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 126, no. 51, 2 December 2004 (2004-12-02), US AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., pages 17016 - 17024, XP002380793
E CERASOLI ET AL.: "ZiCo. a peptide designed to switch folded state upon binding zinc", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 127, no. 43, 2005, US AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., pages 15008 - 15009, XP002380794
E CERASOLI ET AL.: "ZiCo. a peptide designed to switch folded state upon binding zinc", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 127, no. 43, 2005, US AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., pages 15008 - 15009, XP002380794
Download PDF:
Previous Patent: GASTRIN AND CHOLECYSTOKININ RECEPTOR LIGANDS
Next Patent: GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH
Next Patent: GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH