Title:
PEPTIDES AND PEPTIDE ANALOGUES DESIGNED FROM HFE PROTEIN AND THEIR USES IN THE TREATMENT OF IRON OVERLOAD DISEASES
Document Type and Number:
WIPO Patent Application WO2000037482
Kind Code:
A3
Abstract:
The present invention relates to peptides and peptide analogues designed from HFE protein. In particular, it relates to peptides and peptide analogues designed from an alpha-1 region of HFE protein which lowers the binding affinity of transferrin receptor for transferrin. Such compounds mimic HFE protein function, and reduce iron uptake and/or accumulation by a cell.
Inventors:
FEDER JOHN N
SCHATZMAN RANDALL C
BJORKMAN PAMELA J
BENNETT MELANIE
LEBRON JOSE
SCHATZMAN RANDALL C
BJORKMAN PAMELA J
BENNETT MELANIE
LEBRON JOSE
Application Number:
PCT/US1999/029270
Publication Date:
November 16, 2000
Filing Date:
December 10, 1999
Export Citation:
Assignee:
PROGENITOR INC (US)
CALIFORNIA INST OF TECHN (US)
CALIFORNIA INST OF TECHN (US)
International Classes:
A61K38/10; C07K14/74; A61K38/00; (IPC1-7): A61K38/03; A61K38/04; A61K38/10; C07K7/04; C07K7/08
Domestic Patent References:
| WO1997038137A1 | 1997-10-16 | |||
| WO1998056814A1 | 1998-12-17 |
Foreign References:
| US5712098A | 1998-01-27 |
Other References:
See also references of EP 1140131A4
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