Title:
PEPTIDES THAT SELECTIVELY BIND TO Trop2 AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/049046
Kind Code:
A1
Abstract:
The present disclosure relates to a peptide binding to Trop 2 and a use thereof, wherein, in an attempt to find a peptide having an ability of specifically binding to Trop 2, a peptide (amino acid sequence: CSTLNVESC) that selectively binds to Trop 2 was discovered using a phage display technique. Targeting cancers that are highly resistant to anticancer drugs in breast cancer (in particular, triple-negative breast cancer), pancreatic cancer, and cholangiocarcinoma while having no effective treatments, an effective anticancer drug may be prepared by delivering cancer-specific drugs or developing targeted therapeutic agents using the peptide of the present disclosure.
Inventors:
LEE BYUNG-HEON (KR)
PERMPOON UTTAPOL (KR)
PERMPOON UTTAPOL (KR)
Application Number:
PCT/KR2023/011883
Publication Date:
March 07, 2024
Filing Date:
August 10, 2023
Export Citation:
Assignee:
KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR)
MAHIDOL UNIV (TH)
MAHIDOL UNIV (TH)
International Classes:
C07K7/06; A61K38/00; A61K47/42; A61K47/64; A61K49/00; A61P35/00; G01N33/574
Foreign References:
| KR20170003203A | 2017-01-09 | |||
| US20210238303A1 | 2021-08-05 |
Other References:
"A thesis for the degree of doctor of philosophy in Biochemistry ", 1 February 2021, KYUNGPOOK NATIONAL UNIVERSITY, Korea, article PERMPOON, UTTAPOL: "Identification and application of cholangiocarcinoma targeting peptides for cancer therapy", pages: 1 - 113, XP009553000
LAW, BENEDICT ET AL.: "A mitochondrial targeted fusion peptide exhibits remarkable cytotoxicity", MOLECULAR CANCER THERAPEUTICS, vol. 5, no. 8, August 2006, pages 1944 - 1949, XP055109569, DOI: 10.1158/1535-7163.MCT-05-0509
LEMESHKO, VICTOR V.: "Potential-dependent membrane permeabilization and mitochondrial aggregation caused by anticancer polyargining-KLA peptides", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 493, 10 November 2009 (Online publication date), pages 213 - 220, XP026824054
LAW, BENEDICT ET AL.: "A mitochondrial targeted fusion peptide exhibits remarkable cytotoxicity", MOLECULAR CANCER THERAPEUTICS, vol. 5, no. 8, August 2006, pages 1944 - 1949, XP055109569, DOI: 10.1158/1535-7163.MCT-05-0509
LEMESHKO, VICTOR V.: "Potential-dependent membrane permeabilization and mitochondrial aggregation caused by anticancer polyargining-KLA peptides", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 493, 10 November 2009 (Online publication date), pages 213 - 220, XP026824054
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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