Title:
PEPTIDES THAT STABILIZE PROTEIN ANTIGENS AND ENHANCE PRESENTATION TO CD8+ T CELLS
Document Type and Number:
WIPO Patent Application WO2001040275
Kind Code:
A3
Abstract:
The present invention relates to compositions and methods for stabilizing an antigen and enhancing its presentation to CD8+ T cells. Novel biological tools, therapeutics, and prophylactics comprising a hydrophobic fragment of the bacterial protein lemA and methods of use of the foregoing are provided for the study, treatment, and prevention of human disease.
Inventors:
KURLANDER ROGER J (US)
CHAO ELIZABETH (US)
FIELDS JANET (US)
CHAO ELIZABETH (US)
FIELDS JANET (US)
Application Number:
PCT/US2000/033027
Publication Date:
March 21, 2002
Filing Date:
December 06, 2000
Export Citation:
Assignee:
US HEALTH (US)
KURLANDER ROGER J (US)
CHAO ELIZABETH (US)
FIELDS JANET (US)
KURLANDER ROGER J (US)
CHAO ELIZABETH (US)
FIELDS JANET (US)
International Classes:
C07K14/705; A61K38/00; (IPC1-7): C12N15/62; C07K14/195; C07K14/705
Domestic Patent References:
| WO1993003156A1 | 1993-02-18 | |||
| WO1997025070A2 | 1997-07-17 | |||
| WO1999023229A1 | 1999-05-14 |
Foreign References:
| US5945513A | 1999-08-31 |
Other References:
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; NATARAJ, CHANDRASEKARAN ET AL: "H2M3wt-restricted, Listeria monocytogenes-immune CD8 T cells respond to multiple formylated peptides and to a variety of Gram-positive and Gram-negative bacteria", XP002173000, retrieved from STN Database accession no. 128:203884 CA
N M CHIU ET AL.: "The selection of M3-restricted T cells is dependent on M3 expression and presentation of N-formylated peptides in the thymus", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 190, no. 12, 20 December 1999 (1999-12-20), TOKYO, JP, pages 1869 - 1878, XP002172998, ISSN: 0022-1007
R KURLANDER ET AL.: "The adjacent flanking region plays a critical role in facilitating the presentation of Listeria monocytogenes product lemA to H2 M3wt-restricted peptide-specific murine CD8 cells", JOURNAL OF IMMUNOLOGY, vol. 163, no. 12, 15 December 1999 (1999-12-15), BALTIMORE US, pages 6741 - 6747, XP002172999
N M CHIU ET AL.: "The selection of M3-restricted T cells is dependent on M3 expression and presentation of N-formylated peptides in the thymus", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 190, no. 12, 20 December 1999 (1999-12-20), TOKYO, JP, pages 1869 - 1878, XP002172998, ISSN: 0022-1007
R KURLANDER ET AL.: "The adjacent flanking region plays a critical role in facilitating the presentation of Listeria monocytogenes product lemA to H2 M3wt-restricted peptide-specific murine CD8 cells", JOURNAL OF IMMUNOLOGY, vol. 163, no. 12, 15 December 1999 (1999-12-15), BALTIMORE US, pages 6741 - 6747, XP002172999
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