Title:
PEPTIDES FOR TRANSFERRING TARGET MOLECULES INTO CELLS
Document Type and Number:
WIPO Patent Application WO/2014/104227
Kind Code:
A1
Abstract:
The purpose of the present is to provide peptides for transferring target molecules into cells, said peptides enabling target polymer compounds and nanocarriers to be transferred into cells with greater efficiency than peptides of the prior art. The peptides for transferring target molecules into cells include pH-dependent membrane fusion peptides and protein transduction domains (PTDs). The number of amino acids constituting the membrane fusion peptides is not less than 21.
Inventors:
SUZUKI YASUHIRO (JP)
Application Number:
PCT/JP2013/084963
Publication Date:
July 03, 2014
Filing Date:
December 26, 2013
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
C12N15/09; A61K47/42; A61K47/48; A61K48/00; C07K14/155; C07K19/00
Domestic Patent References:
| WO2011126974A1 | 2011-10-13 | |||
| WO2013165816A2 | 2013-11-07 | |||
| WO2013166155A1 | 2013-11-07 |
Other References:
LEE YJ ET AL.: "Modeling of the endosomolytic activity of HA2-TAT peptides with red blood cells and ghosts", BIOCHEMISTRY, vol. 49, no. 36, 2010, pages 7854 - 7866
WADIA JS ET AL.: "Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis", NAT. MED., vol. 10, no. 3, 2004, pages 310 - 315
WADIA JS ET AL.: "Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis", NAT. MED., vol. 10, no. 3, 2004, pages 310 - 315
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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