Title:
PEPTIDES
Document Type and Number:
WIPO Patent Application WO/2014/072958
Kind Code:
A8
Abstract:
The present invention provides peptides partly derivable from FVIII which are capable of binding to an MHC class II molecule without further antigen processing and being recognised by a factor VIII specific T cell. In particular, the present invention provides peptides comprising the sequence DNIMVTFRNQASRPY or PRCLTRYYSSFVNME with modifications at the N-and C-termini. The present invention also relates to the use of such a peptide for the prevention or suppression of inhibitor antibody formation in haemophilia A and/or acquired haemophilia.
Inventors:
WRAITH DAVID (GB)
STREETER HEATHER (GB)
STREETER HEATHER (GB)
Application Number:
PCT/IB2013/060060
Publication Date:
October 13, 2016
Filing Date:
November 11, 2013
Export Citation:
Assignee:
APITOPE INT NV (BE)
International Classes:
C07K14/755; A61K38/00; A61K38/37; A61K39/00
Attorney, Agent or Firm:
HOLLIDAY, Louise (120 Holborn, London EC1N 2DY, GB)
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