Title:
PEPTIDES
Document Type and Number:
WIPO Patent Application WO/2015/019302
Kind Code:
A3
Abstract:
The present invention provides a peptide at least partially derivable from human Thyroid Stimulating Hormone Receptor (TSHR) which peptide is capable of binding to an MHC molecule in vitro and being presented to a T cell without further antigen processing. The present invention also relates to the use of such peptides for the prevention or suppression of activating autoantibody formation in Graves' Disease.
Inventors:
WRAITH DAVID (GB)
Application Number:
PCT/IB2014/063739
Publication Date:
August 27, 2015
Filing Date:
August 06, 2014
Export Citation:
Assignee:
APITOPE INT NV (BE)
International Classes:
C07K7/08; A61K39/00; C07K14/72
Domestic Patent References:
| WO2007057778A2 | 2007-05-24 | |||
| WO2002016410A2 | 2002-02-28 | |||
| WO2010133834A2 | 2010-11-25 |
Foreign References:
| FR2842812A1 | 2004-01-30 |
Other References:
HIDEFUMI INABA ET AL: "Immune Response of Mice Transgenic for Human Histocompatibility Leukocyte Antigen-DR to Human Thyrotropin Receptor-Extracellular Domain", THYROID, vol. 19, no. 11, 1 November 2009 (2009-11-01), pages 1271 - 1280, XP055159862, ISSN: 1050-7256, DOI: 10.1089/thy.2008.0349
TANDON N ET AL: "T cell responses to synthetic TSH receptor peptides in Graves' disease", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING LTD, GB, vol. 89, no. 3, 1 September 1992 (1992-09-01), pages 468 - 473, XP002531204, ISSN: 0009-9104
JACOBSON ET AL: "The HLA gene complex in thyroid autoimmunity: From epidemiology to etiology", JOURNAL OF AUTOIMMUNITY, LONDON, GB, vol. 30, no. 1-2, 4 January 2008 (2008-01-04), pages 58 - 62, XP022418509, ISSN: 0896-8411, DOI: 10.1016/J.JAUT.2007.11.010
TANDON N ET AL: "T cell responses to synthetic TSH receptor peptides in Graves' disease", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING LTD, GB, vol. 89, no. 3, 1 September 1992 (1992-09-01), pages 468 - 473, XP002531204, ISSN: 0009-9104
JACOBSON ET AL: "The HLA gene complex in thyroid autoimmunity: From epidemiology to etiology", JOURNAL OF AUTOIMMUNITY, LONDON, GB, vol. 30, no. 1-2, 4 January 2008 (2008-01-04), pages 58 - 62, XP022418509, ISSN: 0896-8411, DOI: 10.1016/J.JAUT.2007.11.010
Attorney, Agent or Firm:
HOLLIDAY, Louise (120 Holborn, London EC1N 2DY, GB)
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