Title:
PEPTIDYL-PROLYL CIS-TRANS ISOMERASE INHIBITORS AND USES THEREFOR
Document Type and Number:
WIPO Patent Application WO1999063931
Kind Code:
A9
Abstract:
The invention relates to inhibitors of PPIase activity and pharmaceutical compositions containing such inhibitors. Such compounds are useful for treatment of disorders characterized by inappropriate cell proliferation. In particular the compounds disclosed herein inhibit the activity of members of the Pin1/parvulin class of PPIases. These compounds have been designed based on the high resolution X-ray derived crystal structure of the human enzyme Pin1.
Inventors:
NOEL JOSEPH P (US)
HUNTER TONY R (US)
HUNTER TONY R (US)
Application Number:
PCT/US1999/012544
Publication Date:
March 30, 2000
Filing Date:
June 04, 1999
Export Citation:
Assignee:
SALK INST FOR BIOLOGICAL STUDI (US)
NOEL JOSEPH P (US)
HUNTER TONY R (US)
NOEL JOSEPH P (US)
HUNTER TONY R (US)
International Classes:
A61K31/13; A61K31/185; A61K31/21; A61K38/00; C12N9/90; A61K38/05; A61P11/00; A61P13/08; A61P15/00; A61P17/06; A61P31/04; A61P31/10; A61P35/00; A61P35/02; C07F9/572; (IPC1-7): A61K31/045; A61K31/095; A61K31/33; A61K38/02
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