PEPTIDYLARGININE DEIMINASE INHIBITOR AND USE THEREOF - NANJING TRANSTHERA BIOSCIENCES CO LTD

Title:

PEPTIDYLARGININE DEIMINASE INHIBITOR AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2021/057910

Kind Code:

A1

Abstract:

Disclosed is a peptidylarginine deiminase inhibitor and a use thereof. In particular, the present invention relates to a compound of peptidylarginine deiminase PAD4 inhibitor represented by formula (I) and various subformulas, a pharmaceutically acceptable salt, a stereoisomer, a tautomer, a pharmaceutical composition, a pharmaceutical preparation, and a use thereof. Each variable in the general formula is as defined in the specification. The related compound has an inhibitory effect on peptidylarginine deiminase PAD4 and can be used to treat various diseases, such as rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, multiple sclerosis, cystic fibrosis, cancer, cutaneous lupus erythematosus, asthma, and psoriasis.

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Inventors:

WU FRANK (CN)
LI LIN (CN)
WAN ZHONGHUI (CN)

Application Number:

PCT/CN2020/117802

Publication Date:

April 01, 2021

Filing Date:

September 25, 2020

Export Citation:

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Assignee:

NANJING TRANSTHERA BIOSCIENCES CO LTD (CN)

International Classes:

C07D491/048; A61K31/4184; A61K31/4545; A61P35/00; A61P37/00; C07D417/14; C07D495/04

Domestic Patent References:

WO2019161803A1	2019-08-29
WO2017100594A1	2017-06-15
WO2014015905A1	2014-01-30
WO2016185279A1	2016-11-24

Attorney, Agent or Firm:

CHINA PATENT AGENT (H.K.) LTD. (CN)

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