Title:
PEPTOID OLIGOMERS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2010/098843
Kind Code:
A3
Abstract:
Novel peptoid oligomers are disclosed that have a formula represented by the following formula I. The peptoids demonstrate antimicrobial activity and may be prepared as pharmaceutical compositions and used for the prevention or treatment of a variety of conditions in mammals including humans where microbial invasion is involved. The present cyclic and linear peptoids are particularly valuable as their effect is rapid, broad in spectrum and mostly indifferent to resistance provoked by standard antibiotics.
Inventors:
KIRSHENBAUM KENT (US)
SHIN SUNG BIN (US)
SHIN SUNG BIN (US)
Application Number:
PCT/US2010/000541
Publication Date:
January 13, 2011
Filing Date:
February 24, 2010
Export Citation:
Assignee:
UNIV NEW YORK (US)
KIRSHENBAUM KENT (US)
SHIN SUNG BIN (US)
KIRSHENBAUM KENT (US)
SHIN SUNG BIN (US)
International Classes:
C07D259/00; A61K31/395; A61K38/08; A61P31/04; A61P31/12
Other References:
NATHANIEL P. CHONGSIRIWATANA ET AL.: "Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides", THE PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 105, no. 8, 26 February 2008 (2008-02-26), pages 2794 - 2799, XP008140931
SARAH A. FOWLER ET AL.: "Structure-function relationships in peptoids: Recent advances toward deciphering the structural requirements for biological function", ORG. BIOMOL. CHEM., vol. 7, 11 February 2009 (2009-02-11), pages 1508 - 1524, XP008156006
SARAH A. FOWLER ET AL.: "Design and synthesis of macrocyclic peptomers as mimics of a Quorum sensing from staphyllococcus aureus", ORGANIC LETTERS, vol. 10, no. 12, 2008, pages 2329 - 2332, XP002597426
ANDREA R. STATZ ET AL.: "Surface-immobilized antimicrobial peptoides", BIOFOULING, vol. 24, no. 6, 2008, pages 439 - 448, XP008141831
SARAH A. FOWLER ET AL.: "Structure-function relationships in peptoids: Recent advances toward deciphering the structural requirements for biological function", ORG. BIOMOL. CHEM., vol. 7, 11 February 2009 (2009-02-11), pages 1508 - 1524, XP008156006
SARAH A. FOWLER ET AL.: "Design and synthesis of macrocyclic peptomers as mimics of a Quorum sensing from staphyllococcus aureus", ORGANIC LETTERS, vol. 10, no. 12, 2008, pages 2329 - 2332, XP002597426
ANDREA R. STATZ ET AL.: "Surface-immobilized antimicrobial peptoides", BIOFOULING, vol. 24, no. 6, 2008, pages 439 - 448, XP008141831
Attorney, Agent or Firm:
JACKSON, David, A. (411 Hackensack AvenueHackensack, NJ, US)
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