Title:
PERCUTANEOUS ABSORPTION PROMOTER AND EXTERNAL SKIN PREPARATION
Document Type and Number:
WIPO Patent Application WO/2012/096276
Kind Code:
A1
Abstract:
A percutaneous absorption promoter which comprises a lipopeptide compound or a salt thereof. In a static Franz cell test using a physiologically active component with a log P value of -5.5-1.0, the percutaneous absorption promoter can promote the skin permeation rate, for example, twice or more per wt% of the lipopeptide compound or a salt thereof compared with a case wherein the lipopeptide compound or a salt thereof is not added. An example of the lipopeptide compound is surfactin that is represented by formula (1).
Inventors:
IZUMIDA MASASHI (JP)
YANAGISAWA SATOHIRO (JP)
YANAGISAWA SATOHIRO (JP)
Application Number:
PCT/JP2012/050324
Publication Date:
July 19, 2012
Filing Date:
January 11, 2012
Export Citation:
Assignee:
KANEKA CORP (JP)
IZUMIDA MASASHI (JP)
YANAGISAWA SATOHIRO (JP)
IZUMIDA MASASHI (JP)
YANAGISAWA SATOHIRO (JP)
International Classes:
A61K47/42; A61K8/64
Domestic Patent References:
| WO2009044279A2 | 2009-04-09 |
Foreign References:
| JP2003128512A | 2003-05-08 | |||
| JPS5225013A | 1977-02-24 | |||
| JP2009062288A | 2009-03-26 | |||
| JP2000327591A | 2000-11-28 |
Other References:
NICOLI S. ET AL.: "Effect of lipopeptides and iontophoresis on aciclovir skin delivery", J PHARM PHARMACOL, vol. 62, no. 6, 2010, pages 702 - 708
Attorney, Agent or Firm:
UEKI, Kyuichi et al. (JP)
Hisakazu Ueki (JP)
Hisakazu Ueki (JP)
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Claims: