Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
PERFLUOROALKYL-CONTAINING METAL COMPLEXES AND THEIR USE IN NMR DIAGNOSTICS
Document Type and Number:
WIPO Patent Application WO1997026017
Kind Code:
A3
Abstract:
The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.

Inventors:
PLATZEK JOHANNES
NIEDBALLA ULRICH
RADUECHEL BERND
SCHLECKER WOLFGANG
WEINMANN HANNS-JOACHIM
FRENZEL THOMAS
MISSELWITZ BERND
EBERT WOLFGANG
Application Number:
PCT/EP1997/000209
Publication Date:
November 20, 1997
Filing Date:
January 16, 1997
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SCHERING AG (DE)
International Classes:
A61K49/00; C07D295/22; A61K49/10; A61P35/00; A61P43/00; B65D25/16; B65D47/08; B65D83/00; C07C229/16; C07C229/22; C07C229/76; C07C235/10; C07C237/08; C07C237/10; C07C311/05; C07C311/06; C07D257/02; C07D295/26; C07F5/00; C07F13/00; (IPC1-7): A61K49/00
Foreign References:
US5401493A1995-03-28
EP0592306A21994-04-13
EP0628316A11994-12-14
US5248498A1993-09-28
Other References:
LEE H ET AL: "In vivo fluorine-19 MR imaging: relaxation enhancement with Gd-DTPA.", J MAGN RESON IMAGING, JUL-AUG 1994, VOL. 4, NO. 4, PAGE(S) 609-13, XP002041354
THOMAS SR ET AL: "Evaluation of the influence of the aqueous phase bioconstituent environment on the F-19 T1 of perfluorocarbon blood substitute emulsions.", J MAGN RESON IMAGING, JUL-AUG 1994, VOL. 4, NO. 4, PAGE(S) 631-5, XP002041355
GONG B ET AL: "PARAMETER OPTIMIZATION AND CALIBRATION OF FLUORINE-19 MAGNETIC RESONANCE IMAGING AT 1.5 TESLA", MAGN RESON IMAGING, 1991, VOL. 9, NO. 1, PAGE(S) 101-106., XP002041356
RATNER A V ET AL: "FLUORINE-19 RELAXATION RATE ENHANCEMENT AND FREQUENCY SHIFT WITH GADOLINIUM-DTPA", INVEST RADIOL, 1989, VOL. 24, NO. 3, PAGE(S) 224-227., XP002041357
Download PDF: