Title:
PERFORMING PHARMACODYNAMICS EVALUATIONS USING MICROFLUIDIC DEVICES
Document Type and Number:
WIPO Patent Application WO/2022/051510
Kind Code:
A3
Abstract:
Microfluidic platforms including multiple microphysiological systems. At least one of the platforms include: at least one inlet; a plurality of organ constructs, each organ construct of the plurality of organ constructs being sized relative to other organ constructs of the plurality of organ constructs based on at least one predetermined human pharmacokinetic (PK) parameter; and a plurality of channels, each channel of the plurality of channels causing an organ construct of the plurality of organ constructs to be in fluidic communication with at least one other organ construct of the plurality of organ constructs.
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Inventors:
CIRIT MURAT (US)
Application Number:
PCT/US2021/048885
Publication Date:
April 14, 2022
Filing Date:
September 02, 2021
Export Citation:
Assignee:
JAVELIN BIOTECH INC (US)
International Classes:
A01N1/02
Domestic Patent References:
| WO2019222559A1 | 2019-11-21 |
Foreign References:
| US20170227525A1 | 2017-08-10 |
Other References:
SASSERATH ET AL.: "Differential Monocyte Actuation in a Three-Organ Functional Innate Immune System-on-a-Chip", ADVANCED SCIENCE, vol. 7, no. 2000323, 2 June 2020 (2020-06-02), pages 1 - 19, XP055930266
MAASS ET AL.: "Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS", INTEGRATIVE BIOLOGY, vol. 9, no. 4, 18 April 2017 (2017-04-18), pages 290 - 302, XP055930267
MAASS ET AL.: "Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS", INTEGRATIVE BIOLOGY, vol. 9, no. 4, 18 April 2017 (2017-04-18), pages 290 - 302, XP055930267
Attorney, Agent or Firm:
MCDONOUGH, Christina V. (US)
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