PERIPHERALLY DELIVERED GLUTAMIC ACID DECARBOXYLASE GENE THERAPY FOR SPINAL CORD INJURY PAIN

Title:

PERIPHERALLY DELIVERED GLUTAMIC ACID DECARBOXYLASE GENE THERAPY FOR SPINAL CORD INJURY PAIN

Document Type and Number:

WIPO Patent Application WO2006050211

Kind Code:

A3

Abstract:

The invention provides a vector, preferably a herpes simplex virus (HSV) vector, comprising a polynucleotide sequence encoding a glutamic acid decarboxylase (GAD) protein. The invention also provides a stock of such vectors and a pharmaceutical composition comprising such vectors. The invention further provides a method of treating pain, such as spinal cord injury pain, in a mammal comprising administering to a mammal a vector comprising a nucleotide sequence encoding a glutamic acid decarboxylase (GAD) protein in an amount effective to treat spinal cord injury pain.

Inventors:

GLORIOSO JOSEPH C (US)
FINK DAVID J (US)
WOLFE DARREN (US)
KRISKY DAVID (US)

Application Number:

PCT/US2005/039162

Publication Date:

October 19, 2006

Filing Date:

October 28, 2005

Export Citation:

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Assignee:

M OF HIGHER EDUCATION UNIVERSI (US)
GLORIOSO JOSEPH C (US)
FINK DAVID J (US)
WOLFE DARREN (US)
KRISKY DAVID (US)

International Classes:

C07K14/435

Domestic Patent References:

WO2001082973A2	2001-11-08
WO2002016420A2	2002-02-28

Foreign References:

US5998584A

1999-12-07

Other References:

LIU J ET AL: "Peripherally Delivered Glutamic Acid Decarboxylase Gene Therapy for Spinal Cord Injury Pain", MOLECULAR THERAPY, ACADEMIC PRESS, SAN DIEGO, CA,, US, vol. 10, no. 1, July 2004 (2004-07-01), pages 57 - 66, XP004660537, ISSN: 1525-0016
HAO SHUANGLIN ET AL: "Gene transfer of glutamic acid decarboxylase reduces neuropathic pain", ANNALS OF NEUROLOGY, vol. 57, no. 6, June 2005 (2005-06-01), pages 914 - 918, XP002388903, ISSN: 0364-5134

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