Title:
PERMEABILITY MEASUREMENT DEVICE AND METHOD
Document Type and Number:
WIPO Patent Application WO/2023/152143
Kind Code:
A1
Abstract:
The present application relates to a device for measuring the permeability of a porous material to a fluid, the device comprising: - an air cavity (4) of a specific volume; - a material module, the material module comprising: · a support (2) which is configured to contain a volume of fluid; and · the porous material (3); wherein the air cavity (4) and the support (2) are arranged such that a specific thickness, H, of the porous material (3) is between the volume of fluid and the air cavity, a wall of the air cavity (4) being partially formed by the porous material; the device (1) additionally comprising: - means (10) for measuring the pressure, Pc, in the air cavity (4) over time; - means (11) for controlling the pressure of the volume of fluid, which are configured to apply a pressure, PB, to the volume of fluid so as to induce a flow through the porous material in the air cavity; and - digital means which are configured to: · determine the pressure gradient between the volume of fluid and the air cavity (4), VP - (PB-Pc)/H; · determine the flow rate of the fluid through the porous material on the basis of the time-related derivative of the air pressure in the cavity, dPc/dt; and · determine the permeability of the porous material on the basis of the flow rate and of the pressure gradient VP. The present application also relates to a method for measuring the permeability of a porous material to a fluid.
Inventors:
CACHEUX JEAN (JP)
BANCAUD AURÉLIEN (JP)
MATSUNAGA YUKIKO (JP)
JALABERT LAURENT (FR)
BANCAUD AURÉLIEN (JP)
MATSUNAGA YUKIKO (JP)
JALABERT LAURENT (FR)
Application Number:
PCT/EP2023/053024
Publication Date:
August 17, 2023
Filing Date:
February 07, 2023
Export Citation:
Assignee:
CENTRE NAT RECH SCIENT (FR)
International Classes:
G01N15/08; G01N15/00
Domestic Patent References:
| WO2016190939A2 | 2016-12-01 | |||
| WO2013086502A1 | 2013-06-13 |
Other References:
YOUNG E W ET AL: "Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 82, no. 3, 5 January 2010 (2010-01-05), pages 808 - 816, XP002721402, ISSN: 0003-2700, [retrieved on 20100105], DOI: 10.1021/AC901560W
JEAN CACHEUX ET AL: "Asymmetry of tensile vs. compressive elasticity and permeability contributes to the regulation of exchanges in collagen gels", ARXIV.ORG, CORNELL UNIVERSITY LIBRARY, 201 OLIN LIBRARY CORNELL UNIVERSITY ITHACA, NY 14853, 2 December 2022 (2022-12-02), XP091384729
"Transport ofMolécules in the Tumor interstitium : A review", CANCER RES, vol. 47, pages 3039
" Measurement of interstitialfluid pressure : Comparison ofMethods »", ANNALS BIOMED ENGINEERING, vol. 14, pages 139
J.P. OLLIVIER, M. MASSAT: " Permeability and microstructure of concrète: a review of modelling »", CEMENT AND CONCRETE RESEARCH, vol. 22, 1992, pages 503 - 514
ROSTI ET AL.: "The Breakdown of Darcy's Law in a Soft Porous Material", SOFT MATTER, vol. 16, 2020, pages 939 - 944
JEAN CACHEUX ET AL: "Asymmetry of tensile vs. compressive elasticity and permeability contributes to the regulation of exchanges in collagen gels", ARXIV.ORG, CORNELL UNIVERSITY LIBRARY, 201 OLIN LIBRARY CORNELL UNIVERSITY ITHACA, NY 14853, 2 December 2022 (2022-12-02), XP091384729
"Transport ofMolécules in the Tumor interstitium : A review", CANCER RES, vol. 47, pages 3039
" Measurement of interstitialfluid pressure : Comparison ofMethods »", ANNALS BIOMED ENGINEERING, vol. 14, pages 139
J.P. OLLIVIER, M. MASSAT: " Permeability and microstructure of concrète: a review of modelling »", CEMENT AND CONCRETE RESEARCH, vol. 22, 1992, pages 503 - 514
ROSTI ET AL.: "The Breakdown of Darcy's Law in a Soft Porous Material", SOFT MATTER, vol. 16, 2020, pages 939 - 944
Attorney, Agent or Firm:
HAUTIER IP (FR)
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