Title:
PERMEATION ENHANCING COMPOSITIONS FOR ANTICHOLINERGIC AGENTS
Document Type and Number:
WIPO Patent Application WO/2005/107812
Kind Code:
A1
Abstract:
A transdermal or topical composition including anticholinergic agents, such as oxybutynin, a urea-containing compound and a carrier system. A method is disclosed for treating a subject for urinary incontinence while reducing the incidences of peak concentrations of drug and undesirable side effects.
Inventors:
GRENIER ARNAUD (FR)
CARRARA DARIO NORBERTO R (CH)
BESSE CELINE (FR)
CARRARA DARIO NORBERTO R (CH)
BESSE CELINE (FR)
Application Number:
PCT/EP2005/004799
Publication Date:
November 17, 2005
Filing Date:
May 03, 2005
Export Citation:
Assignee:
ANTARES PHARMA IPL AG (CH)
GRENIER ARNAUD (FR)
CARRARA DARIO NORBERTO R (CH)
BESSE CELINE (FR)
GRENIER ARNAUD (FR)
CARRARA DARIO NORBERTO R (CH)
BESSE CELINE (FR)
International Classes:
A61K9/00; A61K9/06; A61K9/70; A61K31/17; A61K31/195; A61K47/10; A61K47/18; (IPC1-7): A61K47/18; A61K9/70; A61P13/10
Domestic Patent References:
| WO2001080796A1 | 2001-11-01 |
Foreign References:
| US6235306B1 | 2001-05-22 |
Other References:
OSBORNE D W ET AL: "Skin penetration enhancers cited in the technical literature", PHARMACEUTICAL TECHNOLOGY 1997 UNITED STATES, vol. 21, no. 11, 1997, pages 58,60,62,64,66, XP009052032, ISSN: 0147-8087
WILLIAMS A C ET AL: "UREA ANALOGUES IN PROPYLENE GLYCOL AS PENETRATION ENHANCERS IN HUMAN SKIN", INTERNATIONAL JOURNAL OF PHARMACEUTICS, AMSTERDAM, NL, vol. 56, no. 1, 1 November 1989 (1989-11-01), pages 43 - 50, XP000645464, ISSN: 0378-5173
TAKAHASHI KOICHI ET AL: "Effect of vehicles on diclofenac permeation across excised rat skin", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. 18, no. 4, 1995, pages 571 - 575, XP001207030, ISSN: 0918-6158
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 1989, STÜTTGEN G: "[Promoting penetration of locally applied substances by urea]", XP002337932, Database accession no. NLM2807923
WILLIAMS A C ET AL: "UREA ANALOGUES IN PROPYLENE GLYCOL AS PENETRATION ENHANCERS IN HUMAN SKIN", INTERNATIONAL JOURNAL OF PHARMACEUTICS, AMSTERDAM, NL, vol. 56, no. 1, 1 November 1989 (1989-11-01), pages 43 - 50, XP000645464, ISSN: 0378-5173
TAKAHASHI KOICHI ET AL: "Effect of vehicles on diclofenac permeation across excised rat skin", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. 18, no. 4, 1995, pages 571 - 575, XP001207030, ISSN: 0918-6158
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 1989, STÜTTGEN G: "[Promoting penetration of locally applied substances by urea]", XP002337932, Database accession no. NLM2807923
Attorney, Agent or Firm:
Straus, Alexander (Kurig Strau, Bavariastrasse 7 München, DE)
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