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Title:
PERSISTENT PROTEIN CONJUGATE WITH IMPROVED EFFICIENCY
Document Type and Number:
WIPO Patent Application WO/2019/066603
Kind Code:
A1
Abstract:
The present invention relates to a protein conjugate, in which a physiologically active polypeptide modified with a fatty acid molecule and an immunoglobulin Fc region are linked through a non-peptide polymer linker, a pharmaceutical composition comprising the same, and a method for preparing the protein conjugate. The protein conjugate extends the blood half-life of the physiologically active polypeptide through the linkage of the binding site of immunoglobulin Fc and the intramolecular bonding of the fatty acid molecule; has an excellent in vivo activity; and provides a protein conjugate having no risk of inducing an immune response.

Inventors:
LEE JONG-SOO (KR)
KIM EUN JUNG (KR)
KIM DAE JIN (KR)
Application Number:
PCT/KR2018/011616
Publication Date:
April 04, 2019
Filing Date:
October 01, 2018
Export Citation:
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Assignee:
HANMI PHARM IND CO LTD (KR)
International Classes:
C07K19/00; A61K38/00; A61K47/54; A61K47/68; C07K14/62
Domestic Patent References:
WO1997034631A11997-09-25
WO1996032478A11996-10-17
WO2014133324A12014-09-04
Foreign References:
KR20140106455A2014-09-03
KR20170065016A2017-06-12
KR20050047032A2005-05-19
KR20150140177A2015-12-15
US6277375B12001-08-21
US6410008B12002-06-25
US6444792B12002-09-03
KR20050047032A2005-05-19
KR101058290B12011-08-22
KR20140106452A2014-09-03
Other References:
BHATNAGAR, S.: "Molecular variants and derivatives of insulin for improved glycemic control in diabetes", PROGRESS IN BIOPHYSICS AND MOLECULAR BIOLOGY, vol. 91, 2006, pages 199 - 228, XP025078418, DOI: doi:10.1016/j.pbiomolbio.2005.05.012
H. NEURATHR. L. HILL: "The Proteins", 1979, ACADEMIC PRESS
CHOU ET AL., PNAS, vol. 112, no. 8, pages 2401 - 2406
Attorney, Agent or Firm:
SON, Min (KR)
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