Title:
PERTUSSIS TOXIN BINDING PROTEIN
Document Type and Number:
WIPO Patent Application WO/2021/000886
Kind Code:
A1
Abstract:
Provided are a single domain antibody against pertussis toxin (PT), a humanized single domain antibody, a derived protein thereof and use thereof.
Inventors:
XU TING (CN)
WANG XIAOXIAO (CN)
WANG LING (CN)
ZHU DANMING (CN)
GAO LI (CN)
WANG XIAOXIAO (CN)
WANG LING (CN)
ZHU DANMING (CN)
GAO LI (CN)
Application Number:
PCT/CN2020/099691
Publication Date:
January 07, 2021
Filing Date:
July 01, 2020
Export Citation:
Assignee:
SUZHOU ALPHAMAB CO LTD (CN)
International Classes:
A61K39/40; C07K16/12; A61P31/04; C12N15/13; C12N15/63; C12P21/08; G01N33/569
Domestic Patent References:
| WO1994004678A1 | 1994-03-03 | |||
| WO2003048731A2 | 2003-06-12 |
Foreign References:
| CN106459183A | 2017-02-22 | |||
| CN108254556A | 2018-07-06 | |||
| CN105039259A | 2015-11-11 | |||
| US4708871A | 1987-11-24 | |||
| CN102558355A | 2012-07-11 | |||
| CN103388013A | 2013-11-13 | |||
| US10035846B2 | 2018-07-31 |
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HAMERS-CASTERMAN CATARHOUCH TMUYLDERMANS SROBINSON GHAMERS CSONGA EBBENDAHMAN NHAMERS R: "Naturally occurring antibodies devoid of light chains", NATURE, vol. 363, 1993, pages 446 - 448, XP002535892, DOI: 10.1038/363446a0
RIECHMANNMUYLDERMANS, J. IMMUNOL. METHODS, vol. 231, 1999, pages 25 - 38
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTES OF HEALTH
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
R. VAN DER LINDEN ET AL., JOURNAL OF IMMUNOLOGICAL METHODS, vol. 240, 2000, pages 185 - 195
LI ET AL., J BIOL CHEM, vol. 287, 2012, pages 13713 - 13721
DEFFAR ET AL., AFRICAN JOURNAL OF BIOTECHNOLOGY, vol. 8, no. 12, 17 June 2009 (2009-06-17), pages 2645 - 2652
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
GEYSEN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 3998 - 4002
GEYSEN ET AL., MOLEC. IMMUNOL., vol. 23, 1986, pages 709 - 715
"UniProtKB", Database accession no. P04981
"Computational Molecular Biology, Lesk", 1988, OXFORD UNIVERSITY PRESS
"Biocomputing: Informatics and Genome Projects", 1993, ACADEMIC PRESS
"Computer Analysis of Sequence Data", 1994, HUMANA PRESS
VON HEINJE, G.: "Sequence Analysis in Molecular Biology", 1987, ACADEMIC PRESS
LEONARD G PRESTA, CURRENT OPINION IN IMMUNOLOGY, vol. 20, 2008, pages 460 - 470
ESOHE E. IDUSOGIE ET AL., J IMMUNOL, vol. 164, 2000, pages 4178 - 4184
RAPHAEL A. CLYNES ET AL., NATURE MEDICINE, vol. 6, no. 4, 2000, pages 443 - 446
PAUL R. HINTON ET AL., J IMMUNOL, vol. 176, 2006, pages 346 - 356
BERGE, S.M. ET AL., J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
LEWIN: "Genes IV", 1990, OXFORD UNIVERSITY PRESS
HAMERS-CASTERMAN CATARHOUCH TMUYLDERMANS SROBINSON GHAMERS CSONGA EBBENDAHMAN NHAMERS R: "Naturally occurring antibodies devoid of light chains", NATURE, vol. 363, 1993, pages 446 - 448, XP002535892, DOI: 10.1038/363446a0
RIECHMANNMUYLDERMANS, J. IMMUNOL. METHODS, vol. 231, 1999, pages 25 - 38
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTES OF HEALTH
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
R. VAN DER LINDEN ET AL., JOURNAL OF IMMUNOLOGICAL METHODS, vol. 240, 2000, pages 185 - 195
LI ET AL., J BIOL CHEM, vol. 287, 2012, pages 13713 - 13721
DEFFAR ET AL., AFRICAN JOURNAL OF BIOTECHNOLOGY, vol. 8, no. 12, 17 June 2009 (2009-06-17), pages 2645 - 2652
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
GEYSEN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 3998 - 4002
GEYSEN ET AL., MOLEC. IMMUNOL., vol. 23, 1986, pages 709 - 715
"UniProtKB", Database accession no. P04981
"Computational Molecular Biology, Lesk", 1988, OXFORD UNIVERSITY PRESS
"Biocomputing: Informatics and Genome Projects", 1993, ACADEMIC PRESS
"Computer Analysis of Sequence Data", 1994, HUMANA PRESS
VON HEINJE, G.: "Sequence Analysis in Molecular Biology", 1987, ACADEMIC PRESS
LEONARD G PRESTA, CURRENT OPINION IN IMMUNOLOGY, vol. 20, 2008, pages 460 - 470
ESOHE E. IDUSOGIE ET AL., J IMMUNOL, vol. 164, 2000, pages 4178 - 4184
RAPHAEL A. CLYNES ET AL., NATURE MEDICINE, vol. 6, no. 4, 2000, pages 443 - 446
PAUL R. HINTON ET AL., J IMMUNOL, vol. 176, 2006, pages 346 - 356
BERGE, S.M. ET AL., J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD (CN)
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