Title:
PES HOLLOW FIBER MEMBRANE FOR PURIFICATION OF BIOMACROMOLECULE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/142842
Kind Code:
A1
Abstract:
Provided in the present invention are a PES hollow fiber membrane for the purification of a biomacromolecule, and a preparation method therefor and the use thereof. The PES hollow fiber membrane comprises a main body, wherein there are a plurality of slit-shaped first holes in an inner surface of the main body, the average value of the aperture width of the first holes is 60nm - 450nm, the hole area rate of the first holes in the inner surface is 5% - 30%, and the direction of the aperture width of the first holes is consistent with a circumferential direction of the hollow fiber membrane, so that the membrane has high interception efficiency, various biomacromolecules are purified in a tangential flow filtration mode, and the interception molecular weight of the membrane is 100K - 750K. In a thickness direction of the membrane from an inner surface to an outer surface, the average aperture of the main body is increased first and then decreased. The main body comprises a separation layer and a support layer, the support layer comprises a first macroporous region, and the average aperture of the first macroporous region is at least four times the average value of the aperture width of the first holes. The presence of the first macroporous region enables the membrane to have a high flux, and can also provide a buffer effect, the membrane permeability resistance can be reduced, and the energy conversion rate of a membrane assembly is higher.
Inventors:
JIA ANDY (CN)
HUANG Hs (CN)
YANG KAY (CN)
HUANG Hs (CN)
YANG KAY (CN)
Application Number:
PCT/CN2022/142584
Publication Date:
August 03, 2023
Filing Date:
December 28, 2022
Export Citation:
Assignee:
HANGZHOU COBETTER FILTRATION EQUIPMENT CO LTD (CN)
International Classes:
B01D69/08; B01D71/68
Foreign References:
| CN114452844A | 2022-05-10 | |||
| JP2007289886A | 2007-11-08 | |||
| US20100219122A1 | 2010-09-02 | |||
| CN101484234A | 2009-07-15 | |||
| CN113522051A | 2021-10-22 |
Attorney, Agent or Firm:
HANGZHOU CHUANGZHIZHUOYING INTELLECTUAL PROPERTY AGENCY ( GENERAL PARTNERSHIP) (CN)
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