Description Invertebrate pests and in particular insects, arachnids and nematodes destroy growing and harvested crops and attack wooden dwelling and commercial structures, thereby causing large economic loss to the food supply and to property. Accordingly, there is an ongoing need for new agents for combating invertebrate pests.

Carbamoylated and thiocarbamoylated oxime derivatives are known for pesticidal use, for exam- pie, in patent publications WO 2016/156076, semi-carbazones and thiosemicarbazones derivatives are known for pesticidal use in patent publication WO 2016/1 16445.

Due to the ability of target pests to develop resistance to pesticidally-active agents, there is an ongoing need to identify further compounds, which are suitable for combating invertebrate pests such as insects, arachnids and nematodes. Furthermore, there is a need for new compounds having a high pesticidal activity and showing a broad activity spectrum against a large number of different invertebrate pests, especially against difficult to control insects, arachnids and nematodes.

It is therefore an object of the present invention to identify and provide compounds, which exhibit a high pesticidal activity and have a broad activity spectrum against invertebrate pests.

It has been found that these objects can be achieved by substituted bicyclic compounds of for- mula I, as depicted and defined below, including their stereoisomers, their salts, in particular their agriculturally or veterinarily acceptable salts, their tautomers and their N-oxides.

In a first aspect, the present invention relates to the compounds of formula I,

Wherein

A is N or CR ^A ;

G is N or CR ^B ;

R, R ^A , and R ^B are H, halogen, N ₃ , OH, CN, N0 ₂ , -SCN, -SF ₅ , C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₁ -C ₆ - alkoxy, C ₁ -C ₆ -haloalkoxy, C2-C ₆ -alkenyl, tri-C ₁ -C ₆ -alkylsilyl, C2-C ₆ -alkynyl, C ₁ -C ₆ -alkoxy-C ₁ -C4- alkyl, C ₁ -C ₆ -alkoxy-C ₁ -C4-alkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -cycloalkoxy, C ₃ -C ₆ -cycloalkyl-C ₁ -C4- alkyl, C ₁ -C4-alkyl-C ₃ -C ₆ -cycloalkoxy, which are unsubstituted or substituted with halogen, C(0)-OR ^a , NR ^b R ^c , C ₁ -C ₆ -alkylen-NR ^b R ^c , 0-C ₁ -C ₆ -alkylen-NR ^b R ^c , C ₁ -C ₆ -alkylen-CN, NH-C ₁ - C ₆ -alkylen-NR ^b R ^c , C(0)-NR ^b R ^c , C(0)-R ^d , S0 ₂ NR ^b R ^c , or S(=0) _m R ^e , one radical may also be phenyl, phenoxy, phenylcarbonyl, phenylthio or benzyl, wherein the rings are unsubstituted or substituted with R ^f ;

Q is NR ² , O, or S(=0) _m , wherein

R ² is H, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -alkoxy-C ₁ -C ₄ -al- kyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -cycloalkyl-C ₁ -C4-alkyl, C ₃ -C ₆ -cycloalkoxy-C ₁ -C ₄ -alkyl, which are unsubstituted or substituted with halogen,

C(0)-OR ^a , C ₁ -C ₆ -alkylen-NR ^b R ^c , C ₁ -C ₆ -alkylen-CN,

C(0)-NR ^b R ^c , C(0)-R ^d , S0 ₂ NR ^b R ^c , S(=0) _m R ^e , phenyl, or benzyl, wherein the rings are unsubstituted or substituted with R ^f ;

Ar is phenyl or 5- or 6-membered hetaryl, which are unsubstituted or substituted with R ^Ar ,

wherein

R ^Ar is halogen, N ₃ , OH, CN, N0 ₂ , -SCN, -SF ₅ , C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₁ -C ₆ -alkoxy, C ₁ -C ₆ -haloalkoxy, C ₂ -C ₆ -alkenyl, tri-C ₁ -C ₆ -alkylsilyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -alkoxy-C ₁ -C ₄ - alkyl, C ₁ -C ₆ -alkoxy-C ₁ -C ₄ -alkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -cycloalkoxy, C ₃ -C ₆ -cycloalkyl- C ₁ -C ₄ -alkyl, C ₃ -C ₆ -cycloalkoxy-C ₁ -C ₄ -alkyl, which are unsubstituted or substituted with halogen,

C(0)-OR ^a , NR ^b R ^c , C ₁ -C ₆ -alkylen-NR ^b R ^c , 0-C ₁ -C ₆ -alkylen-NR ^b R ^c , C ₁ -C ₆ -alkylen-CN, NH- C ₁ -C ₆ -alkylen-NR ^b R ^c , C(0)-NR ^b R ^c , C(0)-R ^d , S0 ₂ NR ^b R ^c , or S(=0) _m R ^e , one radical may also be phenyl, phenoxy, phenylcarbonyl, phenylthio, or benzyl, where the rings are un- substituted or substituted with R ^f ;

R ¹ is a moiety of formula X-Y-Z-T-R ¹¹ or X-Y-Z-T-R ¹² ; wherein

X is -CR ^xa R ^xb -, -0-, -S-, -NR ^XC -, -CR ^xa =CR ^xb - -CR ^xa R ^xb -CR ^xa R ^xb -, -0-CR ^xa R ^xb - -S-CR ^{X" a} R ^xb -, -N=CR ^xa -, -NR ^xc -CR ^xa R ^xb -, -NR ^XC -C(=S)-, -N=C(S-R ^e )-, or -NR ^xc -C(=0)-; Y is -CR ^ya =N- wherein the N is bound to Z;

-NR ^yc -C(=0)-, wherein C(=0) is bound to Z; and

-NR ^yc -C(=S)-, wherein C(=S) is bound to Z;

Z is a single bond;

-NR ^ZC -C(=S)-, wherein C(=S) is bound to T;

-NR ^zc -C(=0)-, wherein C(=0) is bound to T;

-N=C(S-R ^za )-, wherein T is bound to the carbon atom;

-0-C(=0)-, wherein T is bound to the carbon atom;

-0-C(=S)-, wherein T is bound to the carbon atom; and

-NR ^zc -C(S-R ^za )=, wherein T is bound to the carbon atom;

T is O, N or N-R ^T ;

R ¹¹ is C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -alkoxy-C ₁ -C ₄ -alkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -cycloalkyl-C ₁ -C ₄ -alkyl, C ₁ -C ₄ -alkyl-C ₃ -C ₆ -cycloalkoxy, which are unsubstituted or substituted with halogen,

C ₁ -C ₆ -alkylen-NR ^b R ^c , C ₁ -C ₆ -alkylen-CN, C(0)-NR ^b R ^c , C(0)-R ^d , aryl, arylcarbonyl, aryl- C ₁ -C ₄ -alkyl, aryloxy-C ₁ -C ₄ -alkyl, hetaryl, carbonylhetaryl, hetaryl-C ₁ -C ₄ -alkyl, or he- taryloxy-C ₁ -C ₄ -alkyl, where the rings are unsubstituted or substituted with Rs and wherein the hetaryl is a 5- or 6-membered monocyclic hetaryl or a 8-, 9- or 10-mem- bered bicyclic hetaryl;

R ¹² is a radical of the formula A ¹ ;

wherein # indicates the point of attachment to T;

_R i2i _R 122 _R 123 _{are H} , halogen, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -al- kynyl, C ₁ -C ₆ -alkoxy-C ₁ -C4-alkyl, C ₁ -C ₆ -alkoxy, C ₁ -C ₆ -haloalkoxy, C ₁ -C ₆ -alkenyloxy, d-C ₆ -alkynyloxy, C ₁ -C ₆ -alkoxy-C ₁ -C4-alkoxy, C ₁ -C ₆ -alkylcarbonlyoxy, C ₁ -C ₆ - haloalkylcarbonlyoxy, C ₁ -Gralkenylcarbonlyoxy, C ₃ -C ₆ -cycloalkylcarbonlyoxy, or NR ^b R ^c , or one of R ¹²¹ , R ¹²² , R ¹²³ may also be oxo;

R ¹²⁴ is H, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₁ -C ₆ -alkoxy-C ₁ -C ₄ -alkyl, C ₁ -C ₆ -alkoxy, C ₁ -C ₆ - haloalkoxy, or C2-C ₆ -alkenyloxy;

and where

Rxa Rxb R ^y a _are |-|, halogen, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -alkoxy, C ₁ -C ₆ -haloalkyl, C ₁ -C ₆ -haloalkoxy, C ₂ - C ₆ -alkenyl, d-C ₆ -alkynyl, C ₁ -C ₆ -alkoxy-C ₁ -C ₄ -alkyl, C ₃ -C ₆ -cycloalkyl, C ₁ -C ₄ -alkyl-d-C ₆ - cycloalkyl, C ₁ -C ₄ -alkyl-C ₃ -C ₆ -cycloalkoxy, which are unsubstituted or substituted with halogen,

C(0)-OR ^a , C ₁ -C ₆ -alkylen-NR ^b R ^c , C ₁ -C ₆ -alkylen-CN, C(0)-NR ^b R ^c , C(0)-R ^d , S0 ₂ NR ^b R ^c ,

S(=0) _m R ^e , phenyl, or benzyl, wherein the rings are unsubstituted or substituted with R ^f ; R ^XC R ^y e Rzc _are |-|, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₄ -alkyl- C ₁ -C ₆ -alkoxy, C ₃ -C ₆ -cycloalkyl, C ₁ -C ₄ -alkyl-C ₃ -C ₆ -cycloalkyl, or C ₁ -C ₄ -alkyl-C ₃ -C ₆ -cyclo- alkoxy, which are unsubstituted or substituted with halogen;

R ^T is H, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, d-C ₆ -alkenyl, d-C ₆ -alkynyl, C ₁ -C ₄ -alkyl-C ₁ -C ₆ - alkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -cycloalkyl-C ₁ -C ₄ -alkyl, C ₃ -C ₆ -cycloalkoxy-C ₁ -C ₄ -alkyl, where the alkyl, which are unsubstituted or substituted with halogen,

C(0)-OR ^a , C ₁ -C ₆ -alkylen-NR ^b R ^c , C ₁ -C ₆ -alkylen-CN, C(0)-NR ^b R ^c , C(0)-R ^d , S0 ₂ NR ^b R ^c , S(=0) _m R ^e , phenyl, or benzyl, wherein the rings are unsubstituted or substituted with R ^f ; R ^zc together with R ^T if present, may form C ₁ -C ₆ -alkylene or a linear d-C ₆ -alkenylene group, where in the linear C ₁ -C ₆ -alkylene and the linear d-C ₆ -alkenylene a CH ₂ moiety may be replaced by a carbonyl or a C=N-R' and/or wherein 1 or 2 CH ₂ moieties may be replaced by O or S and/or wherein the linear C ₁ -C ₆ -alkylene and the linear C ₂ -C ₆ - alkenylene are unsubstituted or substituted with R ^h ;

R ^za is H, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₁ -C ₆ -alkoxy, C ₁ -C ₆ -haloalkoxy, C ₂ -C ₆ -alkenyl, tri-C ₁ - C ₆ -alkylsilyl, C2-C ₆ -alkynyl, C ₁ -C ₄ -alkyl-C ₁ -C ₆ -alkoxy, C ₃ -C ₆ -cycloalkyl, C ₁ -C ₄ -alkyl-d- C ₆ -cycloalkoxy, or C ₁ -C ₄ -alkyl-C ₃ -C ₆ -cycloalkyl, which are unsubstituted or substituted with halogen,

C ₁ -C ₆ - alkylen-NR ^b R ^c , C ₁ -C ₆ -alkylen-CN, C(0)-NR ^b R ^c , C(0)-R ^d , phenyl, phenylcarbonyl and benzyl, wherein the rings are unsubstituted or substituted with R ^f ;

R ^za together with R ^T if present, may form C ₁ -C ₆ -alkylene or a linear C ₂ -C ₆ -alkenylene group, where in the linear C ₁ -C ₆ a-lkylene and the linear d-C ₆ -alkenylene a CH ₂ moiety may be replaced by a carbonyl or a C=N-R' and/or wherein 1 or 2 CH ₂ moieties may be replaced by O or S and/or wherein the linear C ₁ -C ₆ -alkylene and the linear C ₂ -C ₆ - alkenylene may be unsubstituted or substituted with R ^h ;

R ^a , R ^b and R ^c are H, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, alkoxCy- ₁ -C ₆ - C ₁ -C ₄ -alkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -cycloalkyl-C ₁ -C4-alkyl, C ₃ -C ₆ -cycloalkoxy-d-d-al- kyl, which are unsubstituted or substituted with halogen,

C ₁ -C ₆ -alkylen-CN, phenyl, or benzyl, wherein the rings are unsubstituted or substituted with R ^f ;

R ^d is H, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -alkoxy-C ₁ -C ₄ -al- kyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -cycloalkyl-C ₁ -C ₄ -alkyl, C ₃ -C ₆ -cycloalkoxy-C ₁ -C ₄ -alkyl, which are unsubstituted or substituted with halogen,

phenyl, or benzyl, wherein the rings are unsubstituted or substituted with R ^f ;

R ^e is C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -cycloalkyl-C ₁ -C ₄ -alkyl, which are unsubstituted or substituted with halogen,

phenyl, or benzyl, wherein the rings are unsubstituted or substituted with R ^f ;

R ^f is halogen, N ₃ , OH, CN, N0 ₂ , -SCN, -SF ₅ , Ca ₁ lk-Cyl ₆ ,- C ₁ -C ₆ -haloalkyl, C ₁ -C ₆ -alkoxy, C ₁ -C ₆ -haloalkoxy, C ₂ -C ₆ -alkenyl, tri-d-C ₆ -alkylsilyl, C ₂ -C ₆ -alkynyl, aClk ₁ o-Cxy ₆ --d-d- alkyl, C ₁ -C ₆ -alkoxy-d-d-alkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -cycloalkoxy, C ₃ -C ₆ -cycloalkyl- d-C ₄ -alkyl, C ₃ -C ₆ -cycloalkoxyx-C ₁ -C ₄ -alkyl, which are unsubstituted or substituted with halogen,

C(0)-OR ^a , NR ^b R ^c , C ₁ -C ₆ -alkylen-NR ^b R ^c , 0-C ₁ -C ₆ -alkylen-NR ^b R ^c ,

C ₁ -C ₆ - alkylen-CN, NH-C ₁ -C ₆ -alkylen-NR ^b R ^c , C(0)-NR ^b R ^c , C(0)-R ^d , S0 ₂ NR ^b R ^c , or

S(=0) _m R ^e ;

R9 is halogen, N ₃ , OH, CN, N0 ₂ , -SCN, -SF ₅ , C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₁ -C ₆ -alkoxy, C ₁ -C ₆ -haloalkoxy, C ₂ -C ₆ -alkenyl, tri-C ₁ -C ₆ -alkylsilyl, C ₂ -C ₆ -alkynyl, alCko ₁ -xCy- ₆ d- -d- alkyl, C ₁ -C ₆ -alkoxy-C ₁ -C ₄ -alkoxy, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -cycloalkoxy, C ₃ -C ₆ -cycloalkyl- C ₁ -C ₄ -alkyl, C ₃ -C ₆ -cycloalkoxy-C ₁ -C ₄ -alkyl, which are unsubstituted or substituted with halogen,

C(0)-OR ^a , NR ^b R ^c , C ₁ -C ₆ -alkylen-NR ^b R ^c , 0-C ₁ -C ₆ -alkylen-NR ^b R ^c ,

C ₁ -C ₆ -alkylen-CN, NH-C ₁ -C ₆ -alkylen-NR ^b R ^c , C(0)-NR ^b R ^c , C(0)-R ^d , S0 ₂ NR ^b R ^c , or

S(=0) _m R ^e ;

R ^h halogen, OH, C ₁ -C ₆ -alkyl, C ₃ -C ₆ -cycloalkyl, or CN;

m is 0, 1 , or 2;

and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof.

Moreover, the present invention also relates to processes and intermediates for preparing compounds of formula I and to active compound combinations comprising them. Moreover, the present invention relates to agricultural or veterinary compositions comprising the compounds of formula I, and to the use of the compounds of formula I or compositions comprising them for combating or controlling invertebrate pests and/or for protecting crops, plants, plant propagation material and/or growing plants from attack and/or infestation by invertebrate pests. The present invention also relates to methods of applying the compounds of formula I. Furthermore, the present invention relates to seed comprising compounds of formula I. Wherein the compounds of formula I includes N-ox- ides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof.

With due modification of the starting compounds, the compounds of formula I can be prepared by procedures as given in below schemes.

The compounds of the formula (I) can be prepared by the methods described herein after in below reactions and in the synthesis description of the preparation examples. In the reactions below, the radicals Ar, Q, G, R and R ¹ , R ² , R ^xa , R ^ya , R ^yz ,R ^yc , R ^xc , R ¹¹ , R ¹² are as defined above for formula (I), unless otherwise specified.

Compounds of formula (I) in which Z is a single bond or -NR ^ZC -C(=S)- or -NR ^zc -C(=0)- or O- C(=0)- or -0-C(=S)- and T is O, N or N-R ^T denotes compounds of formula la and can be prepared in accordance with the methods described in the examples and by analogy to the methods de- scribed in WO 201 1/017504 and as depicted in below reaction.

In one embodiment of the above reaction, an aldehyde or ketone of the formula (II) is reacted with a compound of formula (E1 ) wherein Z is -NR ^ZC -C(=S)- or-NR ^zc -C(=0)- and T is N, in the presence or in the absence of a solvent. Suitable solvents are polar protic solvents, preferably Ethanol. If the reaction is performed in the absence of a solvent, the compound of the formula (E1) usually also act as solvent. Compounds of the formula (E1 ) are commercially available or can be prepared according to Journal of Medicinal Chemistry, 2010, 53(8), 3048 or Bioorganic & Medicinal Chemistry Letters, 2009, 19(4), 1152-1154 or WO2007003944.

According to another embodiment of the above reaction , an aldehyde or ketone compound of the formula (II) is first reacted with a hydrazine of the formula R ^ZC NHNH ₂ followed by the reaction with an isocyanate of the formula R ¹¹ -NCO or with an isothiocyanate R ¹¹ -NCS to yield a compound of the formula (la), wherein Z is -N(R ^zc )-C(=0) or - N(R ^ZC )-C(=S) and T is N.

According to another embodiment of the above reaction , an aldehyde or ketone compound of the formula (II) is first reacted with a hydroxylamine followed by the reaction with a compounds R ¹² -L, where L is a suitable leaving group, such as halogen or activated OH. Thereby, a compound of the formula (la) will result, wherein Z is a single bond and T is O.

According to another embodiment of the above reaction , an aldehyde or ketone compound of formula (II) is first reacted with a hydroxylamine followed by reaction with an isocyanate of the formula R ¹¹ -NCO or with an isothiocyanate R ¹¹ -NCS to yield a compound of the formula (la), wherein Z is - 0-C(=0)- or -0-C(=S)-and T is N. Compounds of formula (I) in which Z is -NR ^ZC -C(=S)- or -NR ^zc -C(=0)-, wherein C(=S) or C(=0) is bound to T and T is O, N or N-R ^T , denotes compounds of formula lb and can be prepared as shown in reaction below by analogy to the method described in Synthesis, 2010, 2990-2966.

According to the method depicted in the above reaction , an isocyanate compound of the formula (Ilia) is reacted with the compound of formula (E2) by methods known to a person skilled in the art. The isocyanate of the formula (Ilia) may be obtained e.g. via Lossen rearrangement of the corresponding hydroxamic acid (IVa). The isocyanate of the formula (Ilia) may also be obtained via Cur- tius rearrangement of the corresponding azide of the formula (IVb), e.g. by analogy to the method described in WO 2014/204622. To this end, the hydroxamic acid is reacted with 1-pro- panephosphonic acid cyclic anhydride (T3P) in the presence of a base. The base is preferably N- methylmorpholine.

For converting compounds of formula (lb) in which R ^yz or R ^zc is H into compounds (lb) in which R ^yz or R ^xz is not H, compounds of formula (lb) in which R ^yz or R ^zc is H can be reacted with compounds of formulae R ^yz -Lg or R ^zc -Lg wherein R ^yz or R ^zc is not H and Lg is a leaving group, such as a bromine, chlorine or iodine atom or a tosylate, mesylate or triflate, to yield compounds of formula (lb), wherein Ry ^z or R ^zc is different from H. The reaction is suitably carried out in the presence of a base such as sodium hydride or potassium hydride, suitably in a polar aprotic solvent such as N,N-dime- thylformamide, tetrahydrofuran, dioxane, acetonitrile, dimethylsulfoxide or pyridine, or mixtures of these solvents, in a temperature range of from 0 °C and 100 °C.

Compounds of formula (I) in which Z is a single bond and T is O, N or N-R ^T , denotes compounds of formula Ic and can be prepared as shown in reaction below by analogy to the methods described in WO 201 1/017513.

In the above reaction, R ^11/12 corresponds to radicals R ¹¹ or R ¹² respectively. The reaction shown above can be performed by analogy to conventional methods of preparing carbamates. According to a first embodiment, the amine of the formula (V) is converted into either an isocyanate or p-nitro- phenyl carbamate followed by treatment with an alcohol of the formula R ¹¹ -OH or R ¹² -OH, respectively, in the presence of an organic or inorganic base. According to another embodiment, the compound of the formula (V) is reacted with a chloroformate of the formula R ^11/12 -0-C(=0)-CI. The chlo- roformate is prepared from the alcohols R ^11/12 OH by treatment with phosgene or triphosgene in the presence of a base, e.g. pyridine.

Compounds of formula (lc), in which Z is -N(R ^zc )-C(=0)- or -N(R ^ZC )-C(=S)- can be prepared by analogy to the methods described in WO 2013/009791 , especially in reactions described therein or by the methods described in US 2012/0202687.

Compounds of the formula (II) where X = -CR ^xa =CR ^xb - or -CR ^xa R ^xb -CR ^xa R ^xb - can be prepared by analogy to the methods described in the examples or prepared by the reactions shown in the following reaction.

In the above reaction, Hal is halogen, preferably chlorine or bromine, in particular, bromine. Suita- ble reaction conditions for performing the above reaction (reaction step (i)) is by a Cu-catalyzed cross-coupling reaction of (Ma) with a alkenyl boronic acid or a alkenyl boronate ester using the methodology described in Journal of the American Chemical Society 2012, 134, 15165-15168. The alkenyl boronic acid or the alkenyl boronate ester can be prepared from the corresponding propar- gylic compounds.

Compounds of the formula (II) where X = -CR ^xa =CR ^xb - can also be prepared by reacting compounds of formula (Mb) with appropriate organophosphoranes (J. Heterocyclic Chem. 28: 1281 (1991 )) or with appropriate organostannanes (Eur. Pat. Appl., 308736) (reaction step (ii), below reaction).

Compounds of the formula (II) where X = -CR ^xa R ^xb -CR ^xa R ^xb - can be prepared from compounds of formula (II) where X = -CR ^xa =CR ^xb - by standard hydrogenation protocols known in organic chemistry such as using hydrogen gas and a suitable metal catalyst as described in March's Advanced Organic Chemistry 6 ^th edition, Michael B. Smith and Jerry March.

Compounds of the formula (II) where X = -0-CR ^xa R ^xb - or -S-CR ^xa R ^xb - can be prepared by anal- ogy to the methods descrbied in below reaction and in accordance with the methods described in the examples

^Ar - (») Compounds of the formula (II) where X = -0-CR ^xa R ^xb - or -S-CR ^xa R ^xb - can be prepared by first reacting compounds of formula (lie) with compounds of the formula Lg-CR ^xa R ^xb -C(0)R ^ya or Lg-CR ^X - ^a R ^xb -C(0)OR" or Lg-CR ^xa R ^xb -CN or Lg-CR ^xa R ^xb -C(OR") ₂ with appropriate protecting groups and where Lg is a leaving group such as a bromine, chlorine or iodine atom or a tosylate, mesylate or triflate, to yield compounds of formula (II) (step (iv)). R" is alkyl, preferably methyl or ethyl. The resulting compounds can then be converted to compounds of the formula (II) by standard deprotec- tion methods - acidic hydrolysis for acetals as described in Greene's Protecting Groups in Organic Synthesis, reduction with reducing agents such as Diisobutylaluminium hydride for nitriles and esters as described in March's Advanced Organic Chemistry 6 ^th edition, Michael B. Smith and Jerry March.

In another embodiment of the reaction, compounds of the formula (II) where X = -0-CR ^xa R ^xb - or - S-CR ^xa R ^xb - can be prepared by first reacting compounds of formula (lid) with compounds of the formula HO/HS-CR ^xa R ^xb -C(0)R ^ya or HO/HS-CR ^xa R ^xb -C(0)OR ^" or HO/HS-CR ^xa R ^xb -CN with appropriate protecting groups, by Cu or Pd catalysed reactions or uncatalysed reactions as described in WO2011 159839 or WO2016027249 or US20070032485 and as depicted in below reaction.

Wherein -Hal is bromine, chlorine or iodine atom or a tosylate, mesylate or triflate; R'" is a boronic acid or an ester of a boronic acid.

Compounds of the formula (II) where X = -N=CR ^xa -, -NR ^xc -CR ^xa R ^xb - -NR ^XC -C(=S)-, -N=C(S- R ^e )-, or -NR ^xc -C(=0)- can be prepared in accordance with the methods described in the examples, from compounds of the formula (lie) or can be prepared in accordance with below reaction.

Compounds of the formula (II) where X = -N=CR ^xa -, -NR ^xc -CR ^xa R ^xb - -NR ^XC -C(=S)-, -N=C(S- R ^e )-, or -NR ^xc -C(=0)- can be prepared by first reacting compounds of formula (Me) with com- pounds of the formula Lg-CR ^xa R ^xb -C(0)R ^ya or Lg-CR ^xa R ^xb -C(0)OR" or Lg-CR ^xa R ^xb -CN or

H(OC)R ^xa -C(0)R ^ya or Lg-(OC)R ^xa -C(0)R ^ya or Lg-(OC)R ^xa -CN with appropriate protecting groups and where Lg is a leaving group such as a bromine, chlorine or iodine atom or a tosylate, mesylate or triflate, to yield compounds of formula (II) (step (vi)). R" is alkyl, preferably methyl or ethyl as described in WO2006065703 or WO 201 1079305. The resulting compounds can then be converted to compounds of the formula (II) by methods described in March's Advanced Organic Chemistry 6 ^th edition, Michael B. Smith and Jerry March.

Compounds of the formula (lib), (lie), (lid) and (Me) can be prepared by analogy to compounds prepared in the literature and in accordance with the compounds prepared in the examples. Usually compounds of the formula (lib), (lie), (lid) and (lie) are prepared by the reactions shown in the fol- lowing reactions.

In the above reactions, -Hal is bromine, chlorine or iodine atom or a tosylate, mesylate or triflate; R'" is a boronic acid of an ester of a boronic acid.

Suitable reaction conditions for performing the preparation of the cyanide compound of the formula (llg) (reaction step (x)) by a Pd-catalyzed aromatic cyanation reaction of an aryl bromide of the formula (lid) with an alkalimetal cyanide, preferably NaCN, can be taken from Journal of the American Chemical Society, 133 (28), 10999-11005; 201 1. The reduction of a cyanide compound (llg) to an aldehyde compound (lib) shown in step (xii) of the above reactions can be performed with a metal alkoxyaluminum hydride. Suitable alkoxyaluminum hydrides are lithium alkoxyaluminum hydrides and sodium alkoxyaluminum hydrides, e.g. Na[AI(OC2H ₅ )3H] . Suitable reaction conditions for step (viii) of the above reaction can be taken from Organic Reactions (Hooboken, NJ, United States), pp 36, 1988. The conversion of the aryl bromide (lid) into the ester compound (llh) is shown in reaction step (vii) of the above reaction. Suitable reaction conditions for this palladium- catalysed reaction can be taken from Journal of Medicinal Chemistry, 52 (22), 7258-7272; 2009. Suitable reaction conditions for performing step (viii) of the above reaction can be taken from Syn- lett, (6), 869-872; 2006. Suitable reaction conditions for performing the reaction step (ix) of the above reaction can be taken from Journal of the American Chemical Society, 124(22), 6343-6348, 2002. Suitable reaction conditions for performing the reaction step (x) of the above reaction can be taken from European Journal of Medicinal Chemistry, 49, 310-323; 2012. Compounds of the formula (Mb) can also made from compounds of formula (lid) by reaction with as strong base like for example n-butyl lithium and with an electrophile, for example Ν,Ν-Dimethylformamide as shown in reaction step (xvi), of the above reaction.

Compounds of the formula (lie) (reaction step (xiii) of the above reaction) can be prepared by reacting compounds of the formula (lid) with ammonia or amines of the formula R ^XC NH ₂ in the presence of a metal catalyst or its salts, preferably copper or its salts as described in Chem. Commun., 2009, 3035-3037. Compounds of formula (lie) can be made from compounds of formula (lid) by oxidation with various oxidation reagents for example, hydrogen peroxide as described in Bioorganic and Medicinal chemistry letters, 2013, 23, 4705-4712. Compounds of formula (lid') can be made from compounds of the formula (lid) by reacting with a Palladium (II) catalyzed reaction with pinacol boronates or by reaction with a base such as n-Butyl lithium and trialkylborates as described in Bioorganic and medicinal chemistry letters, 2013, 23, 4705-4712.

Compounds of the formula (lid) can be prepared from compounds of formula (llh) as per below re

In the above reaction, Hal' can be fluorine, chlorine, bromine or iodine, preferably chlorine or to- sylate, mesylate or triflate. Hal can be chlorine, bromine or iodine, preferably bromine or tosylate, mesylate or triflate. Compounds of the formula (lid) can be prepared from compounds of formula (llh) by reacting with compounds of the formula Ar-OH or Ar-NHR ² by heating in a polar protic or aprotic solvents in an acidic, basic or neutral conditions as described in WO2010129053,

WO2007146824 or Chemical Communications, 2014, 50, 1465.

Compounds of formula (lid) can also be prepared from compounds of formula (IN) by reaction with aromatic halogen compounds or aromatic boronic acids or their esters under Cu(l), Cu(ll) or Pd(ll) catalysed conditions as described in WO 2007056075 or WO2002066480 or by using methods described in Organic Letters 2009, 11 , 2514 as shown in below reaction. Compounds of the formula (llh) and (IN) can be obtained from commercial sources or alternatively be prepared by using methods given in US 20050222228 and Journal of Organic Chemistry, 2002, 77(16), 6908, respectively. Individual compounds of formula I can also be prepared by derivatisation of other compounds of formula I or the intermediates thereof.

If the synthesis yields mixtures of isomers, a separation is generally not necessarily required since in some cases the individual isomers can be interconverted during work-up for use or during application (for example under the action of light, acids or bases). Such conversions may also take place after use, for example in the treatment of plants in the treated plant, or in the harmful fungus to be controlled.

A skilled person will readily understand that the preferences for the substituents, also in particular the ones given in the tables below for the respective substituents, given herein in connection with compounds I apply for the intermediates accordingly. Thereby, the substituents in each case have independently of each other or more preferably in combination the meanings as defined herein.

Unless otherwise indicated, the term "compound(s) according to the invention" or "compound(s) of the invention" or "compound(s) of formula (I)", refers to the compounds of formula I.

The term "compound(s) according to the invention", or "compounds of formula I" comprises the compound(s) as defined herein as well as a stereoisomer, salt, tautomer or N-oxide thereof. The term "compound(s) of the present invention" is to be understood as equivalent to the term "com- pound(s) according to the invention", therefore also comprising a stereoisomer, salt, tautomer or N- oxide thereof.

The term "composition(s) according to the invention" or "composition(s) of the present invention" encompasses composition(s) comprising at least one compound of formula I according to the in- vention as defined above. The compositions of the invention are preferably agricultural or veterinary compositions.

Depending on the substitution pattern, the compounds according to the invention may have one or more centers of chirality, in which case they are present as mixtures of enantiomers or diastere- omers. The invention provides both the single pure enantiomers or pure diastereomers of the com- pounds according to the invention, and their mixtures and the use according to the invention of the pure enantiomers or pure diastereomers of the compounds according to the invention or their mixtures. Suitable compounds according to the invention also include all possible geometrical stereoisomers (cis/trans isomers) and mixtures thereof. Cis/trans isomers may be present with respect to an alkene, carbon-nitrogen double-bond or amide group. The term "stereoisomer(s)" encompasses both optical isomers, such as enantiomers or diastereomers, the latter existing due to more than one center of chirality in the molecule, as well as geometrical isomers (cis/trans isomers). The present invention relates to every possible stereoisomer of the compounds of formula I, i.e. to single enantiomers or diastereomers, as well as to mixtures thereof.

The compounds according to the invention may be amorphous or may exist in one or more differ- ent crystalline states (polymorphs) which may have different macroscopic properties such as stabil- ity or show different biological properties such as activities. The present invention relates to amorphous and crystalline compounds according to the invention, mixtures of different crystalline states of the respective compounds according to the invention, as well as amorphous or crystalline salts thereof.

The term "tautomers" encompasses isomers, which are derived from the compounds of formula I by the shift of an H-atom involving at least one H-atom located at a nitrogen, oxygen or sulphur atom. Examples of tautomeric forms are keto-enol forms, imine-enamine forms, urea-isourea forms, thiourea-isothiourea forms, (thio)amide-(thio)imidate forms etc.

The term "stereoisomers" encompasses both optical isomers, such as enantiomers or diastere- omers, the latter existing due to more than one center of chirality in the molecule, as well as geometrical isomers (cis/trans isomers).

Depending on the substitution pattern, the compounds of the formula I may have one or more centers of chirality, in which case they are present as mixtures of enantiomers or diastereomers. One center of chirality is the carbon ring atom of the isothiazoline ring carrying radical R ¹ . The in- vention provides both the pure enantiomers or diastereomers and their mixtures and the use according to the invention of the pure enantiomers or diastereomers of the compound I or its mixtures. Suitable compounds of the formula I also include all possible geometrical stereoisomers (cis/trans isomers) and mixtures thereof.

The term N-oxides relates to a form of compounds I in which at least one nitrogen atom is present in oxidized form (as NO). To be more precise, it relates to any compound of the present invention which has at least one tertiary nitrogen atom that is oxidized to an N-oxide moiety. N-oxides of compounds I can in particular be prepared by oxidizing e.g. the ring nitrogen atom of an N-hetero- cycle, e.g. a pyridine or pyrimidine ring present in Ar or R ¹¹ , or an imino-nitrogen present in central tricyclic core, with a suitable oxidizing agent, such as peroxo carboxylic acids or other peroxides. The person skilled in the art knows if and in which positions compounds of the present invention may form N-oxides.

Salts of the compounds of the formula I are preferably agriculturally and veterinarily acceptable salts. They can be formed in a customary method, e.g. by reacting the compound with an acid of the anion in question if the compound of formula I has a basic functionality or by reacting an acidic compound of formula I with a suitable base.

Suitable agriculturally or veterinarily acceptable salts are especially the salts of those cations or the acid addition salts of those acids whose cations and anions, which are known and accepted in the art for the formation of salts for agricultural or veterinary use respectively, and do not have any adverse effect on the action of the compounds according to the present invention. Suitable cations are in particular the ions of the alkali metals, preferably lithium, sodium and potassium, of the alkaline earth metals, preferably calcium, magnesium and barium, and of the transition metals, preferably manganese, copper, zinc and iron, and also ammonium (NH ⁴⁺ ) and substituted ammonium in which one to four of the hydrogen atoms are replaced by C ₁ -C4-alkyl, C ₁ -C4-hydroxyalkyl, C1-C4- alkoxy, C ₁ -C4-alkoxy-C ₁ -C4-alkyl, hydroxy-C ₁ -C4-alkoxy-C ₁ -C4-alkyl, phenyl or benzyl. Examples of substituted ammonium ions comprise methylammonium, isopropylammonium, dimethylammonium, diisopropylammonium, trimethylammonium, tetramethylammonium, tetraethylammonium, tetrabu- tylammonium, 2-hydroxyethylammonium, 2-(2-hydroxyethoxy)ethylammonium, bis(2-hydroxy- ethyl)ammonium, benzyltrimethylammonium and benzyl-triethylammonium, furthermore phospho- nium ions, sulfonium ions, preferably tri(C ₁ -C ₄ -alkyl)sulfonium, and sulfoxonium ions, preferably tri(C ₁ -C ₄ -alkyl)sulfoxonium. Suitable acid addition veterinarily acceptable salts, e.g. formed by compounds of formula I containing a basic nitrogen atom, e.g. an amino group, include salts with inorganic acids, for example hydrochlorides, sulphates, phosphates, and nitrates and salts of organic acids for example acetic acid, maleic acid, dimaleic acid, fumaric acid, difumaric acid, methane sul- fenic acid, methane sulfonic acid, and succinic acid.

Anions of useful acid addition salts are primarily chloride, bromide, fluoride, hydrogen sulfate, sulfate, dihydrogen phosphate, hydrogen phosphate, phosphate, nitrate, hydrogen carbonate, carbonate, hexafluorosilicate, hexafluorophosphate, benzoate, and the anions of C ₁ -C ₄ -alkanoic acids, preferably formate, acetate, propionate and butyrate. They can be formed by reacting a compound of formulae I with an acid of the corresponding anion, preferably of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid or nitric acid.

The term "invertebrate pest" as used herein encompasses animal populations, such as insects, arachnids and nematodes, which may attack plants, thereby causing substantial damage to the plants attacked, as well as ectoparasites which may infest animals, in particular warm blooded animals such as e.g. mammals or birds, or other higher animals such as reptiles, amphibians or fish, thereby causing substantial damage to the animals infested.

The term "plant propagation material" is to be understood to denote all the generative parts of the plant such as seeds and vegetative plant material such as cuttings and tubers (e. g. potatoes), which can be used for the multiplication of the plant. This includes seeds, roots, fruits, tubers, bulbs, rhizomes, shoots, sprouts and other parts of plants, including seedlings and young plants, which are to be transplanted after germination or after emergence from soil. The plant propagation materials may be treated prophylactically with a plant protection compound either at or before planting or transplanting. Said young plants may also be protected before transplantation by a total or partial treatment by immersion or pouring.

The term "plants" comprises any types of plants including "modified plants" and in particular "culti- vated plants".

The term "modified plants" refers to any wild type species or related species or related genera of a cultivated plant.

The term "cultivated plants" is to be understood as including plants which have been modified by breeding, mutagenesis or genetic engineering including but not limiting to agricultural biotech prod- ucts on the market or in development (cf. http://www.bio.org/speeches/pubs/er/agri_products.asp). Genetically modified plants are plants, which genetic material has been so modified by the use of recombinant DNA techniques that under natural circumstances cannot readily be obtained by cross breeding, mutations or natural recombination. Typically, one or more genes have been integrated into the genetic material of a genetically modified plant in order to improve certain properties of the plant. Such genetic modifications also include but are not limited to targeted post-translational modification of protein(s), oligo- or polypeptides e. g. by glycosylation or polymer additions such as prenylated, acetylated or farnesylated moieties or PEG moieties.

Plants that have been modified by breeding, mutagenesis or genetic engineering, e. g. have been rendered tolerant to applications of specific classes of herbicides, such as auxin herbicides such as dicamba or 2,4-D; bleacher herbicides such as hydroxylphenylpyruvate dioxygenase (HPPD) inhibi- tors or phytoene desaturase (PDS) inhibittors; acetolactate synthase (ALS) inhibitors such as sul- fonyl ureas or imidazolinones; enolpyruvylshikimate-3-phosphate synthase (EPSPS) inhibitors, such as glyphosate; glutamine synthetase (GS) inhibitors such as glufosinate; protoporphyrinogen- IX oxidase inhibitors; lipid biosynthesis inhibitors such as acetyl CoA carboxylase (ACCase) inhibitors; or oxynil (i. e. bromoxynil or ioxynil) herbicides as a result of conventional methods of breeding or genetic engineering. Furthermore, plants have been made resistant to multiple classes of herbicides through multiple genetic modifications, such as resistance to both glyphosate and glufosinate or to both glyphosate and a herbicide from another class such as ALS inhibitors, HPPD inhibitors, auxin herbicides, or ACCase inhibitors. These herbicide resistance technologies are e. g. described in Pest Managem. Sci. 61 , 2005, 246; 61 , 2005, 258; 61 , 2005, 277; 61 , 2005, 269; 61 , 2005, 286; 64, 2008, 326; 64, 2008, 332; Weed Sci. 57, 2009, 108; Austral. J. Agricult. Res. 58, 2007, 708; Science 316, 2007, 1 185; and references quoted therein. Several cultivated plants have been rendered tolerant to herbicides by conventional methods of breeding (mutagenesis), e. g. Clearfield ^® summer rape (Canola, BASF SE, Germany) being tolerant to imidazolinones, e. g. imazamox, or ExpressSun ^® sunflowers (DuPont, USA) being tolerant to sulfonyl ureas, e. g. tribenuron. Genetic engineering methods have been used to render cultivated plants such as soybean, cotton, corn, beets and rape, tolerant to herbicides such as glyphosate and glufosinate, some of which are commercially available under the trade names RoundupReady ^® (glyphosate-tolerant, Monsanto, U.S.A.), Cultivance ^® (imidazolinone tolerant, BASF SE, Germany) and LibertyLink ^® (glufosinate- tolerant, Bayer CropScience, Germany).

Furthermore, plants are also covered that are by the use of recombinant DNA techniques capable to synthesize one or more insecticidal proteins, especially those known from the bacterial genus Bacillus, particularly from Bacillus thuringiensis, such as δ-endotoxins, e. g. CrylA(b), CrylA(c), CrylF, CrylF(a2), CryllA(b), CrylllA, CrylllB(bl ) or Cry9c; vegetative insecticidal proteins (VIP), e. g. VIP1 , VIP2, VIP3 or VIP3A; insecticidal proteins of bacteria colonizing nematodes, e. g. Photorhab- dus spp. or Xenorhabdus spp.; toxins produced by animals, such as scorpion toxins, arachnid toxins, wasp toxins, or other insect-specific neurotoxins; toxins produced by fungi, such Streptomy- cetes toxins, plant lectins, such as pea or barley lectins; agglutinins; proteinase inhibitors, such as trypsin inhibitors, serine protease inhibitors, patatin, cystatin or papain inhibitors; ribosome-inacti- vating proteins (RIP), such as ricin, maize-RIP, abrin, luffin, saporin or bryodin; steroid metabolism enzymes, such as 3-hydroxysteroid oxidase, ecdysteroid-IDP-glycosyl-transferase, cholesterol oxidases, ecdysone inhibitors or HMG-CoA-reductase; ion channel blockers, such as blockers of sodium or calcium channels; juvenile hormone esterase; diuretic hormone receptors (helicokinin receptors); stilben synthase, bibenzyl synthase, chitinases or glucanases. In the context of the present invention these insecticidal proteins or toxins are to be understood expressly also as pre-tox- ins, hybrid proteins, truncated or otherwise modified proteins. Hybrid proteins are characterized by a new combination of protein domains, (see, e. g. WO 02/015701 ). Further examples of such toxins or genetically modified plants capable of synthesizing such toxins are disclosed, e. g., in

EP-A 374 753, WO 93/007278, WO 95/34656, EP-A 427 529, EP-A 451 878, WO 03/18810 und WO 03/52073. The methods for producing such genetically modified plants are generally known to the person skilled in the art and are described, e. g. in the publications mentioned above. These in- secticidal proteins contained in the genetically modified plants impart to the plants producing these proteins tolerance to harmful pests from all taxonomic groups of athropods, especially to beetles (Coeloptera), two-winged insects (Diptera), and moths (Lepidoptera) and to nematodes (Nema- toda). Genetically modified plants capable to synthesize one or more insecticidal proteins are, e. g., described in the publications mentioned above, and some of which are commercially available such as YieldGard ^® (corn cultivars producing the CrylAb toxin), YieldGard ^® Plus (corn cultivars producing CrylAb and Cry3Bb1 toxins), Starlink ^® (corn cultivars producing the Cry9c toxin), Herculex ^® RW (corn cultivars producing Cry34Ab1 , Cry35Ab1 and the enzyme Phosphinothricin-N-Acetyltransfer- ase [PAT]); NuCOTN ^® 33B (cotton cultivars producing the CrylAc toxin), Bollgard ^® I (cotton cultivars producing the CrylAc toxin), Bollgard ^® II (cotton cultivars producing CrylAc and Cry2Ab2 tox- ins); VIPCOT ^® (cotton cultivars producing a VIP-toxin); NewLeaf ^® (potato cultivars producing the Cry3A toxin); Bt-Xtra ^® , NatureGard ^® , KnockOut ^® , BiteGard ^® , Protecta ^® , Bt1 1 (e. g. Agrisure ^® CB) and Bt176 from Syngenta Seeds SAS, France, (corn cultivars producing the CrylAb toxin and PAT enyzme), MIR604 from Syngenta Seeds SAS, France (corn cultivars producing a modified version of the Cry3A toxin, c.f. WO 03/018810), MON 863 from Monsanto Europe S.A., Belgium (corn culti- vars producing the Cry3Bb1 toxin), IPC 531 from Monsanto Europe S.A., Belgium (cotton cultivars producing a modified version of the CrylAc toxin) and 1507 from Pioneer Overseas Corporation, Belgium (corn cultivars producing the Cryl F toxin and PAT enzyme).

Furthermore, plants are also covered that are by the use of recombinant DNA techniques capable to synthesize one or more proteins to increase the resistance or tolerance of those plants to bacte- rial, viral or fungal pathogens. Examples of such proteins are the so-called "pathogenesis-related proteins" (PR proteins, see, e. g. EP-A 392 225), plant disease resistance genes (e. g. potato cultivars, which express resistance genes acting against Phytophthora infestans derived from the mexi- can wild potato Solanum bulbocastanum) or T4-lysozym (e. g. potato cultivars capable of synthesizing these proteins with increased resistance against bacteria such as Erwinia amylvora). The methods for producing such genetically modified plants are generally known to the person skilled in the art and are described, e. g. in the publications mentioned above.

Furthermore, plants are also covered that are by the use of recombinant DNA techniques capable to synthesize one or more proteins to increase the productivity (e. g. bio mass production, grain yield, starch content, oil content or protein content), tolerance to drought, salinity or other growth- limiting environmental factors or tolerance to pests and fungal, bacterial or viral pathogens of those plants.

Furthermore, plants are also covered that contain by the use of recombinant DNA techniques a modified amount of substances of content or new substances of content, specifically to improve human or animal nutrition, e. g. oil crops that produce health-promoting long-chain omega-3 fatty ac- ids or unsaturated omega-9 fatty acids (e. g. Nexera ^® rape, DOW Agro Sciences, Canada).

Furthermore, plants are also covered that contain by the use of recombinant DNA techniques a modified amount of substances of content or new substances of content, specifically to improve raw material production, e. g. potatoes that produce increased amounts of amylopectin (e. g. Amflora ^® potato, BASF SE, Germany).

The organic moieties mentioned in the above definitions of the variables are - like the term halo- gen - collective terms for individual listings of the individual members. The prefix C _n -C _m indicates in each case the possible number of carbon atoms in the group.

The term halogen denotes in each case F, Br, CI or I, in particular F, CI or Br.

The term "alkyl" as used herein and in the alkyl moieties of alkoxy, alkylthio, and the like refers to saturated straight-chain or branched hydrocarbon radicals having 1 to 2 ("C ₁ -C ₂ -alkyl"), 1 to 3 ("C ₁ - C ₃ -alkyl"),1 to 4 ("C ₁ -C ₄ -alkyl") or 1 to 6 ("C ₁ -C ₆ -alkyl") carbon atoms. C ₁ -C ₂ -Alkyl is CH ₃ or C ₂ H ₅ . d- C ₃ -Alkyl is additionally propyl and isopropyl. C ₁ -C ₄ -Alkyl is additionally butyl, 1-methylpropyl (sec- butyl), 2-methylpropyl (isobutyl) or 1 ,1-dimethylethyl (tert-butyl). C ₁ -C ₆ -Alkyl is additionally also, for example, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, 1 ,1- dimethylpropyl, 1 ,2-dimethylpropyl, hexyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4- methylpentyl, 1 ,1-dimethylbutyl, 1 ,2-dimethylbutyl, 1 ,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dime- thylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1 ,1 ,2-trimethylpropyl, 1 ,2,2-trimethylpropyl, 1- ethyl-1-methylpropyl, or 1-ethyl-2-methylpropyl.

The term "haloalkyl" as used herein, which is also expressed as "alkyl which is partially or fully halogenated", refers to straight-chain or branched alkyl groups having 1 to 2 ("C ₁ -C2-haloal- kyl"), 1 to 3 ("C ₁ -C ₃ -haloalkyl"), 1 to 4 ("C ₁ -C ₄ -haloalkyl") or 1 to 6 ("C ₁ -C ₆ -haloalkyl") carbon atoms (as mentioned above), where some or all of the hydrogen atoms in these groups are replaced by halogen atoms as mentioned above: in particular C ₁ -C ₂ -haloalkyl, such as chloromethyl, bromome- thyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluorome- thyl, dichlorofluoromethyl, chlorodifluoromethyl, 1-chloroethyl, 1-bromoethyl, 1-fluoroethyl, 2-fluoro- ethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-di- chloro-2-fluoroethyl, 2,2,2-trichloroethyl or pentafluoroethyl. C ₁ -C ₃ -haloalkyl is additionally, for example, 1-fluoropropyl, 2-fluoropropyl, 3-fluoropropyl, 1 ,1-difluoropropyl, 2,2-difluoropropyl, 1 ,2- difluoropropyl, 3,3-difluoropropyl, 3,3,3-trifluoropropyl, heptafluoropropyl, 1 , 1 ,1-trifluoroprop-2-yl, 3- chloropropyl and the like. Examples for C ₁ -C ₄ -haloalkyl are, apart those mentioned for C ₁ -C ₃ -haloal- kyl, 4-chlorobutyl and the like.

The term "alkylene" (or alkanediyl) as used herein in each case denotes an alkyl radical as defined above, wherein one hydrogen atom at any position of the carbon backbone is replaced by one further binding site, thus forming a bivalent moiety. Alkylene has preferably 1 to 6 carbon atoms (C ₁ -C ₆ -alkylene), 2 to 6 carbon atoms (C2-C ₆ -alkylene), in particular 1 to 4 carbon atoms (C ₁ - C ₄ -alkylene) or 2 to 4 carbon atoms (C2-C ₄ -alkylene). Examples of alkylene are methylene (CH2), 1 ,1-ethandiyl, 1 ,2-ethandiyl, 1 ,3-propandiyl, 1 ,2-propandiyl, 2,2-propandiyl, 1 ,4-butandiyl, 1 ,2-bu- tandiyl, 1 ,3-butandiyl, 2,3-butandiyl, 2,2-butandiyl, 1 ,5-pentandiyl, 2,2-dimethylpropan-1 ,3-diyl, 1 ,3- dimethyl-1 ,3-propandiyl, 1 ,6-hexandiyl etc.

The term "alkenyl" as used herein refers to monounsaturated straight-chain or branched hy- drocarbon radicals having 2 to 3 ("C ₂ -C ₃ -alkenyl"), 2 to 4 ("C ₂ -C ₄ -alkenyl") or 2 to 6 ("C ₂ -C ₆ -alkenyl) carbon atoms and a double bond in any position, for example C2-C ₃ -alkenyl, such as ethenyl, 1-pro- penyl, 2-propenyl or 1-methylethenyl; C ₂ -C ₄ -alkenyl, such as ethenyl, 1-propenyl, 2-propenyl, 1- methylethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 1-methyl- 2-propenyl or 2-methyl-2-propenyl; C ₂ -C ₆ -alkenyl, such as ethenyl, 1-propenyl, 2-propenyl, 1-meth- ylethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 1-methyl-2- propenyl, 2-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl-1-butenyl, 2-methyl-1-butenyl, 3-methyl-1-butenyl, 1-methyl-2-butenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-methyl-3-butenyl, 3-methyl-3-butenyl, 1 , 1-dimethyl-2-propenyl, 1 ,2-dimethyl- 1-propenyl, 1 ,2-dimethyl-2-propenyl, 1-ethyl-1-propenyl, 1-ethyl-2-propenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-1-pentenyl, 2-methyl-1-pentenyl, 3-methyl-1-pentenyl, 4-methyl-1-pentenyl, 1-methyl-2-pentenyl, 2-methyl-2-pentenyl, 3-methyl-2-pentenyl, 4-methyl-2- pentenyl, 1-methyl-3-pentenyl, 2-methyl-3-pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-pentenyl, 1- methyl-4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-pentenyl, 1 ,1-dimethyl-2- butenyl, 1 ,1-dimethyl-3-butenyl, 1 ,2-dimethyl-1-butenyl, 1 ,2-dimethyl-2-butenyl, 1 ,2-dimethyl-3-bu- tenyl, 1 ,3-dimethyl-1-butenyl, 1 ,3-dimethyl-2-butenyl, 1 ,3-dimethyl-3-butenyl, 2,2-dimethyl-3-bu- tenyl, 2,3-dimethyl-1-butenyl, 2,3-dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 3,3-dimethyl-1-bu- tenyl, 3,3-dimethyl-2-butenyl, 1 -ethyl-1 -butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 2-ethyl-1-bu- tenyl, 2-ethyl-2-butenyl, 2-ethyl-3-butenyl, 1 ,1 ,2-trimethyl-2-propenyl, 1 -ethyl-1 -methyl-2-propenyl, 1-ethyl-2-methyl-1-propenyl, 1-ethyl-2-methyl-2-propenyl and the like.

The term "alkynyl" as used herein refers to straight-chain or branched hydrocarbon groups having 2 to 3 ("C ₂ -C ₃ -alkynyl"), 2 to 4 ("C ₂ -C ₄ -alkynyl") or 2 to 6 ("C ₂ -C ₆ -alkynyl") carbon atoms and one or two triple bonds in any position, for example C ₂ -C ₃ -alkynyl, such as ethynyl, 1-propynyl or 2- propynyl; C ₂ -C ₄ -alkynyl, such as ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl,

1- methyl-2-propynyl and the like, C ₂ -C ₆ -alkynyl, such as ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-

2- butynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 3-methyl-1-butynyl, 1 ,1-dimethyl-2-propynyl, 1- ethyl-2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-me- thyl-3-pentynyl, 1-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-1- pentynyl, 3-methyl-4-pentynyl, 4-methyl-1-pentynyl, 4-methyl-2-pentynyl, 1 ,1-dimethyl-2-butynyl, 1 ,1-dimethyl-3-butynyl, 1 ,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 3,3-dimethyl-1-butynyl, 1- ethyl-2-butynyl, 1-ethyl-3-butynyl, 2-ethyl-3-butynyl, 1 -ethyl- 1-methyl-2-propynyl and the like;

The term "cycloalkyl" as used herein refers to mono- or bi- or polycyclic saturated hydrocarbon radicals having in particular 3 to 6 ("C ₃ -C ₆ -cycloalkyl") or 3 to 5 ("C ₃ -C ₃ -cycloalkyl") or 3 to 4 ("C ₃ -C ₄ -cycloalkyl") carbon atoms. Examples of monocyclic radicals having 3 to 4 carbon atoms comprise cyclopropyl and cyclobutyl. Examples of monocyclic radicals having 3 to 5 carbon atoms comprise cyclopropyl, cyclobutyl and cyclopentyl. Examples of monocyclic radicals having 3 to 6 carbon atoms comprise cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. Examples of monocyclic radicals having 3 to 8 carbon atoms comprise cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl. Examples of bicyclic radicals having 7 or 8 carbon atoms comprise bicy- clo[2.2.1]heptyl, bicyclo[3.1.1]heptyl, bicycio [2.2.2] octyl and bicyclo[3.2.1]octyl. Preferably, the term cycloalkyl denotes a monocyclic saturated hydrocarbon radical. The term "cycloalkoxy" as used herein refers to a cycloalkyl radical, in particular a monocyclic cycloalkyl radical, as defined above having in particular 3 to 6 ("C ₃ -C ₆ -cycloalkoxy") or 3 to 5 ("C ₃ - C5-cycloalkoxy") or 3 to 4 ("C ₃ -C4-cycloalksoxy") carbon atoms, which is bound via an oxygen atom to the remainder of the molecule.

The term "cycloalkyl-C ₁ -C ₄ -alkyl" refers to a C ₃ -C ₈ -cycloalkyl ("C ₃ -C ₈ -cycloalkyl-C ₁ -C ₄ -alkyl"), preferably a C ₃ -C ₆ -cycloalkyl ("C ₃ -C ₆ -cycloalkyl-C ₁ -C ₄ -alkyl"), more preferably a C ₃ -C ₄ -cycloalkyl ("C ₃ -C ₄ -cycloalkyl-C ₁ -C ₄ -alkyl") as defined above (preferably a monocyclic cycloalkyl group) which is bound to the remainder of the molecule via a C ₁ -C ₄ -alkyl group, as defined above. Examples for C ₃ -C ₄ -cycloalkyl-C ₁ -C ₄ -alkyl are cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclobutyl- methyl, cyclobutylethyl and cyclobutylpropyl, Examples for C ₃ -C ₆ -cycloalkyl-C ₁ -C ₄ -alkyl, apart those mentioned for C ₃ -C ₄ -cycloalkyl-C ₁ -C ₄ -alkyl, are cyclopentylmethyl, cyclopentylethyl, cyclopentylpro- pyl, cyclohexylmethyl, cyclohexylethyl and cyclohexyl propyl.

The term "C ₁ -C2-alkoxy" is a C ₁ -C2-alkyl group, as defined above, attached via an oxygen atom. The term "C ₁ -C ₃ -alkoxy" is a C ₁ -C ₃ -alkyl group, as defined above, attached via an oxygen atom. The term "C ₁ -C ₄ -alkoxy" is a C ₁ -C ₄ -alkyl group, as defined above, attached via an oxygen atom. The term "C ₁ -C ₆ -alkoxy" is a C ₁ -C ₆ -alkyl group, as defined above, attached via an oxygen atom. The term "C ₁ -Cio-alkoxy" is a C ₁ -Cio-alkyl group, as defined above, attached via an oxygen atom. C ₁ -C2-Alkoxy is OCH ₃ or OC2H5. C ₁ -C ₃ -Alkoxy is additionally, for example, n-propoxy and 1- methylethoxy (isopropoxy). C ₁ -C ₄ -Alkoxy is additionally, for example, butoxy, 1-methylpropoxy (sec- butoxy), 2-methylpropoxy (isobutoxy) or 1 ,1-dimethylethoxy (tert-butoxy). C ₁ -C ₆ -Alkoxy is additionally, for example, pentoxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 1 ,1-dimethylpropoxy, 1 ,2-dimethylpropoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, hexoxy, 1-methylpentoxy, 2-methylpent- oxy, 3-methylpentoxy, 4-methylpentoxy, 1 ,1-dimethylbutoxy, 1 ,2-dimethylbutoxy, 1 ,3-dimethylbut- oxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy, 2-ethylbutoxy, 1 ,1 ,2-trimethylpropoxy, 1 ,2,2-trimethylpropoxy, 1-ethyl-1-methylpropoxy or 1-ethyl-2- methylpropoxy. d-C ₃ -Alkoxy is additionally, for example, heptyloxy, octyloxy, 2-ethylhexyloxy and positional isomers thereof. C ₁ -Cio-Alkoxy is additionally, for example, nonyloxy, decyloxy and positional isomers thereof.

The term "C ₁ -C2-haloalkoxy" is a C ₁ -C2-haloalkyl group, as defined above, attached via an ox- ygen atom. The term "C ₁ -C ₃ -haloalkoxy" is a C ₁ -C ₃ -haloalkyl group, as defined above, attached via an oxygen atom. The term "C ₁ -C ₄ -haloalkoxy" is a C ₁ -C ₄ -haloalkyl group, as defined above, attached via an oxygen atom. The term "C ₁ -C ₆ -haloalkoxy" is a C ₁ -C ₆ -haloalkyl group, as defined above, attached via an oxygen atom. C ₁ -C2-Haloalkoxy is, for example, OCH ₂ F, OCHF ₂ , OCF ₃ , OCH2CI, OCHC , OCCI ₃ , chlorofluoromethoxy, dichlorofluoromethoxy, chlorodifluoromethoxy, 2- fluoroethoxy, 2-chloroethoxy, 2-bromoethoxy, 2-iodoethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoroeth- oxy, 2-chloro-2-fluoroethoxy, 2-chloro-2,2-difluoroethoxy, 2,2-dichloro-2-fluoroethoxy, 2,2,2-trichlo- roethoxy or OC2F5. C ₁ -C ₃ -Haloalkoxy is additionally, for example, 2-fluoropropoxy, 3-fluoropropoxy, 2,2-difluoropropoxy, 2,3-difluoropropoxy, 2-chloropropoxy, 3-chloropropoxy, 2,3-dichloropropoxy, 2- bromopropoxy, 3-bromopropoxy, 3,3,3-trifluoropropoxy, 3,3,3-trichloropropoxy, OCH2-C2F5, OCF ₂ - C2F5, 1-(CH ₂ F)-2-fluoroethoxy, 1-(CH ₂ CI)-2-chloroethoxy or 1-(CH ₂ Br)-2-bromoethoxy. C1-C4- Haloalkoxy is additionally, for example, 4-fluorobutoxy, 4-chlorobutoxy, 4-bromobutoxy or no- nafluorobutoxy. C ₁ -C ₆ -Haloalkoxy is additionally, for example, 5-fluoropentoxy, 5-chloropentoxy, 5- brompentoxy, 5-iodopentoxy, undecafluoropentoxy, 6-fluorohexoxy, 6-chlorohexoxy, 6-bromo- hexoxy, 6-iodohexoxy or dodecafluorohexoxy.

The term "C ₁ -C ₆ -alkoxy-C ₁ -C ₄ -alkyl" as used herein, refers to a straight-chain or branched al- kyl having 1 to 4 carbon atoms, as defined above, where one hydrogen atom is replaced by a C ₁ - C6-alkoxy group, as defined above. Examples are methoxymethyl, ethoxymethyl, propoxymethyl, isopropoxymethyl, n-butoxymethyl, sec-butoxymethyl, isobutoxymethyl, tert-butoxymethyl, 1-meth- oxyethyl, 1-ethoxyethyl, 1-propoxyethyl, 1-isopropoxyethyl, 1-n-butoxyethyl, 1-sec-butoxyethyl, 1- isobutoxyethyl, 1-tert-butoxyethyl, 2-methoxyethyl, 2-ethoxyethyl, 2-propoxyethyl, 2-isopropoxy- ethyl, 2-n-butoxyethyl, 2-sec-butoxyethyl, 2-isobutoxyethyl, 2-tert-butoxyethyl, 1-methoxypropyl, 1- ethoxypropyl, 1-propoxypropyl, 1-isopropoxypropyl, 1-n-butoxypropyl, 1-sec-butoxypropyl, 1-isobu- toxypropyl, 1-tert-butoxypropyl, 2-methoxypropyl, 2-ethoxypropyl, 2-propoxypropyl, 2-isopropoxy- propyl, 2-n-butoxypropyl, 2-sec-butoxypropyl, 2-isobutoxypropyl, 2-tert-butoxypropyl, 3-methoxypro- pyl, 3-ethoxypropyl, 3-propoxypropyl, 3-isopropoxypropyl, 3-n-butoxypropyl, 3-sec-butoxypropyl, 3- isobutoxypropyl, 3-tert-butoxypropyl and the like.

The term "alkoxyalkoxy" as used herein refers to an alkoxyalkyl radical, in particular a C1-C ₆ - alkoxy-C ₁ -C4-alkyl radical, as defined above, which is bound via an oxygen atom to the remainder of the molecule. Examples thereof are OCH ₂ -OCH ₃ , OCH2-OC2H5, n-propoxymethoxy,

OCH2-OCH(CH ₃ )2, n-butoxymethoxy, (l-methylpropoxy)methoxy, (2-methylpropoxy)methoxy, OCH ₂ -OC(CH ₃ )3, 2-(methoxy)ethoxy, 2-(ethoxy)ethoxy, 2-(n-propoxy)ethoxy, 2-(1-methyleth- oxy)ethoxy, 2-(n-butoxy)ethoxy, 2-(1 -methylpropoxy)ethoxy, 2-(2-methylpropoxy)ethoxy, 2-(1 ,1-di- methylethoxy)ethoxy, etc.

The substituent "oxo" replaces a CH ₂ by a C(=0) group.

The term "aryl" relates to phenyl and bi- or polycyclic carbocycles having at least one fused phenylene ring, which is bound to the remainder of the molecule. Examples of bi- or polycyclic carbocycles having at least one phenylene ring include naphthyl, tetrahydronaphthyl, indanyl, indenyl, anthracenyl, fluorenyl etc.

The term "aryl-C ₁ -C4-alkyl" relates to C ₁ -C4-alkyl, as defined above, wherein one hydrogen atom has been replaced by an aryl radical, in particular a phenyl radical. Particular examples of aryl-C ₁ -C4-alkyl include benzyl, 1-phenethyl, 2-phenetyl, 1-phenylpropyl, 2-phenylpropyl, 3-phenyl- 1-propyl and 2-phenyl-2-propyl.

The term "aryloxy-C ₁ -C ₄ -alkyl" relates to C ₁ -C4-alkyl, as defined above, wherein one hydrogen atom has been replaced by an aryloxy radical, in particular a phenoxy radical. Particular examples of aryloxy-C ₁ -C4-alkyl include phenoxymethyl, 1-phenoxyethyl, 2-phenoxyetyl, 1-phenoxypropyl, 2- phenoxypropyl, 3-phenoxy-1 -propyl and 2-phenoxy-2-propyl.

The term "aryl-C ₁ -C4-carbonyl" relates to aryl as defined above, , in particular a phenyl radical, which is bound by a carbonyl to the remainder of the molecule. Particular examples of arylcar- bonyl include benzoyl, 1-naphthoyl and 2-naphthoyl.

The term hetaryl relates to aromatic heterocycles having either 5 or 6 ring atoms (5- or 6- membered hetaryl) and being monocyclic or 8, 9 or 10 ring atoms and bing bicyclic. Hetaryl will generally have at least one ring atom selected from O, S and N, which in case of N may be an imino-nitrogen or an amino-nitrogen, which carries hydrogen or a radical different from hydrogen. Hetaryl may have 1 , 2, 3 or 4 further nitrogen atoms as ring members, which are imino nitrogens. Examples of 5- or 6-membered hetaryl include 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 1-pyrrolyl, 2-pyr- rolyl, 3-pyrrolyl, 1-pyrazolyl, 3-pyrazolyl, 4-pyrazolyl, 5-pyrazolyl, 2-oxazolyl, 4-oxazolyl, 5-oxazolyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 1-imidazolyl, 2-imidazolyl, 4-imidazolyl, 1 ,3,4-triazol-1-yl, 1 ,3,4- triazol-2-yl, 1 ,3,4-oxadiazolyl-2-yl, 1 ,3,4-thiadiazol-2-yl, 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 3-pyri- dazinyl, 4-pyridazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 2-pyrazinyl and 1 ,3,5-triazin-2-yL Examples of 8-, 9- or 10-membered hetaryl include, for example, quinolinyl, isoquinolinyl, cinnolinyl, indolyl, indolizynyl, isoindolyl, indazolyl, benzofuryl, benzothienyl, benzo[b]thiazolyl, benzoxazolyl, benzthiazolyl, benzimidazolyl, imidazo[1 ,2-a]pyridine-2-yl, thieno[3,2-b]pyridine-5-yl, imidazo-[2,1- b]-thiazol-6-yl and 1 ,2,4-triazolo[1 ,5-a]pyridine-2-yl.

Examples of N-bound 5-, 6-, 7 or 8-membered saturated heterocycles include: pyrrolidin-1-yl, pyrazolidin-1-yl, imidazolidin-1-yl, oxazolidin-3-yl, isoxazolidin-2-yl, thiazolidin-3-yl, isothiazolidin-2- yl, piperidin-1-yl, piperazin-1-yl, morpholin-4-yl, thiomorpholin-4-yl, 1-oxothiomorpholin-4-yl, 1 ,1-di- oxothiomorpholin-4-yl, azepan-1-yl and the like.

The term "hetaryl-C ₁ -C4-alkyl" relates to C ₁ -C4-alkyl, as defined above, wherein one hydrogen atom has been replaced by a hetaryl radical, in particular a pyridyl radical. Particular examples of hetaryl-C ₁ -C4-alkyl include 2-pyridylmethyl, 3-pyridylmethyl, 4-pyridylmethyl, 1-(2-pyridyl)ethyl, 2-(2- pyridyl)ethyl, 1-(3-pyridyl)ethyl, 2-(3-pyridyl)ethyl, 1-(4-pyridyl)ethyl, 2-(4-pyridyl)ethyl etc..

The term "hetaryloxy-C ₁ -C4-alkyl" relates to C ₁ -C4-alkyl, as defined above, wherein one hydrogen atom has been replaced by an hetaryloxy radical, in particular a pyridyloxy radical. Particular examples of hetaryloxy-C ₁ -C4-alkyl include 2-pyridyloxymethyl, 3-pyridyloxymethyl, 4-pyri- dyloxymethyl, 1-(2-pyridyloxy)ethyl, 2-(2-pyridyloxy)ethyl, 1-(3-pyridyloxy)ethyl, 2-(3-pyri- dyloxy)ethyl, 1-(4-pyridyloxy)ethyl, 2-(4-pyridyloxy)ethyl etc.

The term "hetaryl-C ₁ -C4-carbonyl" relates to hetaryl as defined above, in particular a C-bound hetaryl radical, e.g. 2-, 3-or 4-pyridyl, 2- or 3-thienyl, 2- or 3-furyl, 1-, 2- or 3-pyrrolyl, 2- or 4-pyrimidinyl, pyridazinyl, 1-, 3- or 4-pyrazolyl, 1-, 2- or 4-imidazolyl radical, which is bound by a carbonyl to the remainder of the molecule.

The term "substituted" if not specified otherwise refers to substituted with 1 , 2 or maximum possible number of substituents. If substituents as defined in compounds of formula I are more than one then they are independently from each other are same or different if not mentioned otherwise.

With respect to the variables, the embodiments of the compounds of the formula I are,

In one embodiment, A is CR ^A

In another embodiment, A is N.

In one embodiment, G is CR ^B .

In another embodiment, G is N.

In one embodiment, A is CR ^A and G is N.

In another embodiment, A is N and G is CR ^B .

In another embodiment, A is N and G is N. In another embodiment, A is CR ^A and G is CR ^B .

In one embodiment, R is H, halogen, N ₃ , OH, CN, N0 ₂ , -SCN, -SF ₅ , C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, d-C ₆ -alkoxy, C ₁ -C ₆ -haloalkoxy, C ₂ -C ₆ -alkenyl, or tri-d-C ₆ -alkylsilyl.

In more preferred embodiment, R is H, halogen, OH, CN, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₁ -C ₆ - alkoxy, C ₁ -C ₆ -haloalkoxy, C2-C ₆ -alkenyl, or tri-C ₁ -C ₆ -alkylsilyl.

In most preferred embodiment, R is H, CI, Br, F, OH, CN, CH ₃ , C ₂ H ₅ , n-C ₃ H ₇ , isopropyl, cyclopro- pyl, allyl and propargyl, CH ₂ F, CHF ₂ , CF ₃ , OCH ₃ , OC ₂ H ₅ , OCH ₂ F, OCHF ₂ , OCF ₃ , OCH ₂ CH ₂ CF ₃ , OCH ₂ CF ₂ CHF ₂ , or OCH ₂ CF ₂ CF ₃ .

In one embodiment, R ^A is H, halogen, N ₃ , OH, CN, N0 ₂ , -SCN, -SF ₅ , C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, d-C ₆ -alkoxy, C ₁ -C ₆ -haloalkoxy, C ₂ -C ₆ -alkenyl, or tri-C ₁ -C ₆ -alkylsilyl.

In more preferred embodiment, R ^A is H, halogen, OH, CN, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₁ -C ₆ - alkoxy, C ₁ -C ₆ -haloalkoxy, C ₂ -C ₆ -alkenyl, or tri-C ₁ -C ₆ -alkylsilyl.

In most preferred embodiment, R ^A is H, CI, Br, F, OH, CN, CH ₃ , C ₂ H ₅ , n-C ₃ H ₇ , isopropyl, cyclopro- pyl, allyl and propargyl, CH ₂ F, CHF ₂ , CF ₃ , OCH ₃ , OC ₂ H ₅ , OCH ₂ F, OCHF ₂ , OCF ₃ , OCH ₂ CH ₂ CF ₃ , OCH ₂ CF ₂ CHF ₂ , or OCH ₂ CF ₂ CF ₃ .

In one embodiment, R ^B is H, halogen, N ₃ , OH, CN, N0 ₂ , -SCN, -SF ₅ , C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₁ -C ₆ -alkoxy, C ₁ -C ₆ -haloalkoxy, C ₂ -C ₆ -alkenyl, or tri-C ₁ -C ₆ -alkylsilyl.

In more preferred embodiment, R ^B is H, halogen, OH, CN, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₁ -C ₆ - alkoxy, C ₁ -C ₆ -haloalkoxy, C ₂ -C ₆ -alkenyl, or tri-C ₁ -C ₆ -alkylsilyl.

In most preferred embodiment, R ^B is H, CI, Br, F, OH, CN, CH ₃ , C ₂ H ₅ , n-C ₃ H ₇ , isopropyl, cyclopro- pyl, allyl and propargyl, CH ₂ F, CHF ₂ , CF ₃ , OCH ₃ , OC ₂ H ₅ , OCH ₂ F, OCHF ₂ , OCF ₃ , OCH ₂ CH ₂ CF ₃ , OCH ₂ CF ₂ CHF ₂ , or OCH ₂ CF ₂ CF ₃ .

In one embodiment, Q is NR ² .

In another embodiment, Q is O.

In another embodiment, Q is S.

In another embodiment, Q is S(=0).

In another embodiment, Q is S(=0) ₂ .

In more preferred embodiment compounds of formula I are selected from compounds of formula I.A to I. T wherein R ¹ , R ^A , R ^B , R ² and Ar are as defined herein.

wherein, Ar is phenyl or 5- or 6-membered hetaryl ring which is substituted with R ^Ar ;

R ^Ar is halogen, OH, CN, N0 ₂ , SCN, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₁ -C ₆ -alkoxy, C ₁ -C ₆ -haloalkoxy, or S-R ^e , which are unsubstituted or substituted with halogen;

R ² is H, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₄ -alkyl-C ₁ -C ₆ -alkoxy, or C ₃ - C6-cycloalkyl, which are unsubstituted or substituted with halogen,

and phenyl which is unsubstituted or substituted with R ^f ;

R is H, halogen, N ₃ , OH, CN, N0 ₂ , -SCN, -SF ₅ , C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₁ -C ₆ -alkoxy, C ₁ -C ₆ - haloalkoxy, or C ₂ -C ₆ -alkenyl;

R ^A is H, halogen, N ₃ , OH, CN, N0 ₂ , -SCN, -SF ₅ , C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₁ -C ₆ -alkoxy, C ₁ -C ₆ - haloalkoxy, or C ₂ -C ₆ -alkenyl;

R ^B is H, halogen, N ₃ , OH, CN, N0 ₂ , -SCN, -SF ₅ , C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₁ -C ₆ -alkoxy, C ₁ -C ₆ - haloalkoxy, or C ₂ -C ₆ -alkenyl;

and R ¹ is X-Y-Z-T-R ¹¹ and X-Y-Z-T-R ¹² , as defined in formula I.

In another more preferred embodiment compounds of formula I are selected from compounds of formula I.A.1 , I.A.2, I.A.3, I.B.1 , I.B.2, I.B.3, I.B.4, I.B.5, I.C.1 , I.C.1 , I.C.2, I.D.1 , I.D.2, I.E.1 , I.E.2, I.E.3, I.E.4, I.F.1 , I.F.2, I.F.3, I.F.4, I.F.5, I.G.1 , I.G.2, I.G.1 , I.H.1 , I.H.2, 1.1.1 , I.I.2, I.I.3, I.J.1 , I.J.2, I.J.3, I.J.4, I.J.5, I.K.1 , I.K.2, I.K.3, I.L.1 , I.L.2, I.M.1 , I.M.2, I.M.3, I.N.1 , I.N.2, I.N.3, I.N.4, 1.0.1 , I.0.2, 1.0.3, I.P.1 , I.P.2, I.Q.1 , I.Q.2, I.Q.3, I.R.1 , I.R.2, I.R.3, I.R.4, I.S.1 , I.S.2, I.S.3, I.T.1 , I.T.2, and I.T.3, wherein R ¹ , R ² , and Ar are as defined herein.

I.A.1 I.A.2 I.A.3 I.B.1 I.B.2

S S 3 3

In one embodiment, R ² is H, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C2-C ₆ -alkenyl, C2-C ₆ -alkynyl, C ₁ -C4-alkyl- C ₁ -C ₆ -alkoxy, C ₃ -C ₆ -cycloalkyl, which are unsubstituted or substituted with halogen,

phenyl, or benzyl, which are unsubstituted or substituted with R ^f .

In more preferred embodiment, R ² is H, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C2-C ₆ -alkenyl, C2-C ₆ -alkynyl, C ₁ -C4-alkyl-C ₁ -C ₆ -alkoxy, or C ₃ -C ₆ -cycloalkyl.

In most preferred embodiment, R ² is H, CH ₃ , C ₂ H ₅ , n-C ₃ H ₇ , isopropyl, cyclopropyl, allyl and pro- pargyl, CH ₂ F, CHF ₂ , CF ₃ , CH ₂ F, CHF ₂ , CF ₃ , or phenyl which is unsubstituted or substituted with R ^f . In one embodiment, Ar is phenyl which is unsubstituted or substituted with R ^Ar .

In another embodiment, Ar is 5- or 6-membered hetaryl, which is unsubstituted or substituted with R ^Ar .

In another embodiment, Ar is phenyl, pyrimidinyl, pyridazinyl, or pyridyl, which are unsubstituted substituted with R ^Ar . In one embodiment, R ^Ar is halogen, OH, CN, N0 ₂ , SCN, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₁ -C ₆ - alkoxy, C ₁ -C ₆ -haloalkoxy, or S-R ^e , which are unsubstituted substituted with halogen.

In more preferred embodiment, R ^Ar is F, CI , Br, OH, CN, N0 ₂ , SCN, CH ₃ , C ₂ H ₅ , n-C ₃ H ₇ , isopropyl, CH ₂ F, CHF ₂ , CF ₃ , CH ₂ CF ₃ , CF ₂ CHF ₂ , C ₂ F ₅ , CH ₂ CH ₂ CF ₃ , CH ₂ CF ₂ CHF ₂ , CH ₂ CF ₂ CF ₃ , OCH ₃ , OC ₂ H ₅ , n-propyloxy, isopropyloxy, OCH ₂ F, OCHF ₂ , OCF ₃ , OCH ₂ CF ₃ , OCF ₂ CHF ₂ , OC ₂ F ₅ , OCH ₂ CH ₂ CF ₃ , OCH ₂ CF ₂ CHF ₂ , OCH ₂ CF ₂ CF ₃ , or S-R ^e , where R ^e is C ₁ -C ₆ -alkyl, in particular C ₁ -C ₃ -alkyl such asCH ₃ , C ₂ H ₅ , n-C ₃ H ₇ or isopropyl, or C ₁ -C ₆ -haloalkyl, in particular fluorinated C ₁ -C ₃ -alkyl such as CH ₂ F, CHF ₂ , CF ₃ , CH ₂ CF ₃ , CF ₂ CHF ₂ , C ₂ F ₅ , CH ₂ CH ₂ CF ₃ , CH ₂ CF ₂ CHF ₂ or CH ₂ CF ₂ CF ₃ .

Preferred Ar are the radicals Ar-1 to Ar-12 summarized in Table A below.

Table A: Examples of radicals Ar

In one embodiment, R ¹ is X-Y-Z-T-R ¹¹ .

In another embodiment, R ¹ is X-Y-Z-T-R ¹² .

In one embodiment, X is -CR ^xa R ^xb -.

In another embodiment, X is -0-.

In another embodiment, X is -S-.

In another embodiment, X is -NR ^XC -.

In another embodiment, X is -CR ^xa =CR ^xb -.

In another embodiment, X is -CR ^xa R ^xb -CR ^xa R ^xb - In another embodiment, X is -0-CR ^xa R ^xb -.

In another embodiment, X is -S-CR ^xa R ^xb -

In another embodiment, X is -N=CR ^xa -

In another embodiment, X is -NR ^xc -CR ^xa R ^xb - wherein CR ^xa R ^xb is bound to Y.

In another embodiment, X is -NR ^XC -C(=S)-.

In another embodiment, X is -N=C(S-R ^e )-.

In another embodiment, X is -NR ^xc -C(=0)-.

In one embodiment, Y is -CR ^ya =N- wherein the N is bound to Z.

In another embodiment, Y is -NR ^yc -C(=S)-, wherein C(=S) is bound to Z.

In another embodiment, Y is -NR ^yc -C(=0)-, wherein C(=0) is bound to Z. In one embodiment, Z is -NR ^ZC -C(=S)-, wherein C(=S) is bound to T.

In another embodiment, Z is -NR ^zc -C(=0)-, wherein C(=0) is bound to T.

In another embodiment, Z is-N=C(S-R ^za )-, wherein T is bound to the carbon atom.

In another embodiment, Z is -0-C(=0)-, wherein T is bound to the carbon atom.

In another embodiment, Z is -0-C(=S)-, wherein T is bound to the carbon atom.

In another embodiment, Z is-NR ^zc -C(S-R ^za )=, wherein T is bound to the carbon atom.

In another embodiment, Z is a single bond.

In one embodiment, T is O.

In another embodiment, T is N-R ^T .

In another embodiment, T is N.

In one embodiment, R ^xa , R ^xb , R ^ya are H, halogen, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -alkoxy, C ₁ -C ₆ -haloalkyl, C ₁ - C ₆ -haloalkoxy, which are unsubstituted or substituted with halogen,

phenyl, or benzyl, wherein the rings are unsubstituted or substituted with R ^f .

In more preferred embodiment, R ^xa , R ^xb , R ^ya are H, halogen, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -alkoxy, which are unsubstituted or substituted with halogen,

, or phenyl which is unsubstituted or substituted with R ^f .

In most preferred embodiment, R ^xa , R ^xb , R ^ya are H, F, CI , Br, CH ₃ , C ₂ H ₅ , n-C ₃ H ₇ , isopropyl, CH ₂ F, CHF ₂ , CF ₃ , CH2CF3, CF2CHF2, C ₂ F ₅ , CH2CH2CF3, CH2CF2CHF2, CH2CF2CF3, OCH3, OC ₂ H ₅ , n- propyloxy, isopropyloxy, OCH ₂ F, OCHF ₂ , OCF ₃ , OCH2CF3, OCF ₂ CHF ₂ , OC2F5, OCH2CH2CF3, OCH2CF2CHF2, OCH2CF2CF3, or phenyl which is unsubstituted or substituted with R ^f .

In one embodiment, R ^xc , R ^yc , R ^zc are H, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₃ -C ₆ -cycloalkyl, which are unsubstituted or substituted with halogen,

phenyl, or benzyl, wherein the rings are unsubstituted or substituted with R ^f .

In more preferred embodiment, R ^xc , R ^yc , R ^zc are H, C ₁ -C ₆ -alkyl, which are unsubstituted or substi- tuted with halogen,

or phenyl which is unsubstituted or substituted with R ^f .

In most preferred embodiment, R ^xc , R ^yc , R ^zc are H, CH ₃ , C ₂ H ₅ , n-C ₃ H ₇ , isopropyl, CH ₂ F, CHF ₂ , CF ₃ , CH ₂ CF ₃ , CF2CHF2, C2F5, CH ₂ CH ₂ CF ₃ , CH2CF2CHF2, CH ₂ CF ₂ CF ₃ , or phenyl which is unsubstituted or substituted with R ^f .

In one embodiment, R ^T is H, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C4-alkyl- C ₁ -C ₆ -alkoxy, which are unsubstituted or substituted with halogen,

C(0)-NR ^b R ^c , C(0)-R ^d , S0 ₂ NR ^b R ^c , S(=0) _m R ^e , phenyl, or benzyl, wherein the rings are unsubstituted or substituted with R ^f .

In another embodiment, R ^zc together with R ^T if present, forms C ₁ -C ₆ -alkylene or a linear C ₂ -C ₆ - alkenylene group, where in the linear C ₁ -C ₆ -alkylene and the linear C2-C ₆ -alkenylene a CH ₂ moiety may be replaced by a carbonyl or a C=N-R' and/or wherein 1 or 2 CH ₂ moieties may be replaced by O or S and/or wherein the linear C ₁ -C ₆ -alkylene and the linear C2-C ₆ -alkenylene may be unsubstituted or substituted with R ^h .

In more preferred embodiment, R ^zc together with R ^T if present, forms C ₁ -C ₆ -alkylene or a linear C2-C ₆ -alkenylene group, where in the linear C ₁ -C ₆ -alkylene and the linear C2-C ₆ -alkenylene a CH ₂ moiety is replaced by a carbonyl group. In another more preferred embodiment, R ^zc together with R ^T if present, forms C ₁ -C ₆ -alkylene or a linear C ₂ -C ₆ -alkenylene group, where in the linear C ₁ -C ₆ -alkylene and the linear C ₂ -C ₆ -alkenylene a CH ₂ moiety is replaced by a C=N-R' and wherein 1 or 2 CH ₂ moieties may be replaced by O or S and/or wherein the linear C ₁ -C ₆ -alkylene and the linear C ₂ -C ₆ -alkenylene may be unsubstituted or substituted with R ^h .

In another more preferred embodiment, R ^zc together with R ^T if present, forms C ₁ -C ₆ -alkylene or a linear C ₂ -C ₆ -alkenylene group, where in the linear C ₁ -C ₆ -alkylene and the linear C ₂ -C ₆ -alkenylene 1 or 2 CH ₂ moieties are replaced by O or S and/or wherein the linear C ₁ -C ₆ -alkylene and the linear C ₂ -C ₆ -alkenylene may be unsubstituted or substituted with R ^h .

In one embodiment, R ^za is H, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₁ -C ₆ -alkylen-NR ^b R ^c , C ₁ -C ₆ - C(0)-R ^d , phenyl, phenylcarbonyl, or benzyl, wherein the rings are unsubstituted or substituted with R ^f .

In another embodiment, R ^za together with R ^T if present, forms C ₁ -C ₆ -alkylene or a linear C ₂ -C ₆ - alkenylene group, where in the linear C ₁ -C ₆ -alkylene and the linear C ₂ -C ₆ -alkenylene a CH ₂ moiety may be replaced by a carbonyl or a C=N-R' and/or wherein 1 or 2 CH ₂ moieties may be replaced by O or S and/or wherein the linear C ₁ -C ₆ -alkylene and the linear C ₂ -C ₆ -alkenylene may be unsubstituted or substituted with R ^h .

In more preferred embodiment, R ^za together with R ^T if present, forms C ₁ -C ₆ -alkylene or a linear C ₂ -C ₆ -alkenylene group, where in the linear C ₁ -C ₆ -alkylene and the linear C ₂ -C ₆ -alkenylene a CH ₂ moiety is replaced by a carbonyl group.

In another more preferred embodiment, R ^za together with R ^T if present, forms C ₁ -C ₆ -alkylene or a linear C ₂ -C ₆ -alkenylene group, where in the linear C ₁ -C ₆ -alkylene and the linear C ₂ -C ₆ -alkenylene a CH ₂ moiety is replaced by a C=N-R' and wherein 1 or 2 CH ₂ moieties may be replaced by O or S and/or wherein the linear C ₁ -C ₆ -alkylene and the linear C ₂ -C ₆ -alkenylene may be unsubstituted or substituted with R ^h .

In another more preferred embodiment, R ^za together with R ^T if present, forms C ₁ -C ₆ -alkylene or a linear C ₂ -C ₆ -alkenylene group, where in the linear C ₁ -C ₆ -alkylene and the linear C ₂ -C ₆ -alkenylene 1 or 2 CH ₂ moieties are replaced by O or S and/or wherein the linear C ₁ -C ₆ -alkylene and the linear C ₂ -C ₆ -alkenylene may be unsubstituted or substituted with R ^h .

In a preferred embodiment, R ^a , R ^b and R ^c are H , C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -alkenyl, C ₂ - C6-alkynyl, which are unsubstituted or substituted with halogen,

C ₁ -C ₆ -alkylen-CN, phenyl, or benzyl, wherein the rings are unsubstituted or substituted with R ^f ;

In more preferred embodiment, R ^a , R ^b and R ^c are H, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, which are unsubstituted or substituted with halogen,

phenyl, or benzyl, wherein the rings are unsubstituted or substituted with R ^f .

In a preferred embodiment, R ^d is H, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, which are unsubstituted or substituted with halogen,

phenyl, or benzyl, wherein the rings are unsubstituted or substituted with R ^f .

In more preferred embodiment, R ^d is H, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, or phenyl which is unsubstituted or substituted with R ^f .

In one embodiment, R ^e is C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₃ -C ₆ -cycloalkyl, which are unsubstituted or substituted with halogen, phenyl, or benzyl, wherein the rings are unsubstituted or substituted with R ^f .

In more preferred embodiment, R ^e is H, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, or phenyl which is unsubstituted or substituted with R ^f .

In one embodiment, R ^f is halogen, N ₃ , OH, CN, N0 ₂ , -SCN, -SF ₅ , C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₁ - C ₆ -alkoxy, C ₁ -C ₆ -haloalkoxy, C2-C ₆ -alkenyl, C2-C ₆ -alkynyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -cycloalkoxy, which are unsubstituted or substituted with halogen,

C(0)-OR ^a , NR ^b R ^c , C ₁ -C ₆ -alkylen-NR ^b R ^c , C ₁ -C ₆ -alkylen-CN, C(0)-NR ^b R ^c , C(0)-R ^d , S0 ₂ NR ^b R ^c , or S(=0) _m R ^e .

In more preferred embodiment, R ^f is halogen, N ₃ , OH, CN, C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C1-C ₆ - alkoxy, C ₁ -C ₆ -haloalkoxy, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -cycloalkoxy, which are unsubstituted or substituted with halogen,

C(0)-OR ^a , NR ^b R ^c , C ₁ -C ₆ -alkylen-NR ^b R ^c , C ₁ -C ₆ -alkylen-CN, C(0)-NR ^b R ^c , C(0)-R ^d , S0 ₂ NR ^b R ^c , or S(=0) _m R ^e .

In a preferred embodiment, Rs is halogen, N ₃ , OH, CN, N0 ₂ , -SCN, -SF ₅ , C ₁ -C ₆ -alkyl, C ₁ -C ₆ - haloalkyi, C ₁ -C ₆ -alkoxy, C ₁ -C ₆ -haloalkoxy, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -cy- cloalkoxy, which are unsubstituted or substituted with halogen,

C(0)-OR ^a , NR ^b R ^c , C ₁ -C ₆ -alkylen-NR ^b R ^c , NH-C ₁ -C ₆ -alkylen-NR ^b R ^c , C(0)-NR ^b R ^c , C(0)-R ^d ,

S0 ₂ NR ^b R ^c , or S(=0) _m R ^e .

In more preferred embodiment, Rs is halogen, N ₃ , OH, CN, N0 ₂ , C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₁ - C ₆ -alkoxy, C ₁ -C ₆ -haloalkoxy, C ₂ -C ₆ -alkenyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -cycloalkoxy, which are unsubstituted or substituted with halogen,

C(0)-OR ^a , NR ^b R ^c , C ₁ -C ₆ -alkylen-NR ^b R ^c , C(0)-NR ^b R ^c , C(0)-R ^d , S0 ₂ NR ^b R ^c , or S(=0) _m R ^e .

In one embodiment, m is 0.

In another embodiment, m is 1.

In another embodiment, m is 2.

Particularly preferred X-Y-Z-T are formulas XYZT-1 to XYZT-19 wherein denotes attachment to the 6 membered hetaryl and # denotes attachment to R ¹¹ or R ¹² , and wherein R ^e , xa, xb, xy and xc are as defined in compounds of formula I.

XYZT-19

Also particularly preferred X-Y-Z-T are formulas XYZT-1 to XYZT-16;

Also particularly preferred X-Y-Z-T are formulas XYZT-17 to XYZT-19;

In one embodiment, R ¹¹ C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C2-C ₆ -alkenyl, C2-C ₆ -alkynyl, C ₁ -C ₆ -alkoxy- C ₁ -C4-alkyl, C ₃ -C ₆ -cycloalkyl, C ₃ -C ₆ -cycloalkyl-C ₁ -C4-alkyl, C ₁ -C4-alkyl-C ₃ -C ₆ -cycloalkoxy, which are unsubstituted or substituted with halogen,

aryl, arylcarbonyl, aryl-C ₁ -C4-alkyl, aryloxy-C ₁ -C4-alkyl, hetaryl, carbonylhetaryl, C ₁ -C4-alkyl-hetaryl and C ₁ -C4-alkyl-hetaryloxy, where the rings are unsubstituted or substituted with Rs and wherein the hetaryl is a 5- or 6-membered monocyclic hetaryl or a 8-, 9- or 10-membered bicyclic hetaryl. In more preferred embodiment, R ¹¹ C ₁ -C ₆ -alkyl, C2-C ₆ -alkenyl, C2-C ₆ -alkynyl, C ₃ -C ₆ -cycloalkyl, which are unsubstituted or substituted with halogen,

aryl, arylcarbonyl, aryl-C ₁ -C4-alkyl, aryloxy-C ₁ -C4-alkyl, hetaryl, carbonylhetaryl, C ₁ -C4-alkyl-hetaryl and C ₁ -C4-alkyl-hetaryloxy, where the rings are unsubstituted or substituted with Rs and wherein the hetaryl is a 5- or 6-membered monocyclic hetaryl or a 8-, 9- or 10-membered bicyclic hetaryl. In most preferred embodiment, R ¹¹ aryl, aryl-C ₁ -C4-alkyl, hetaryl, or hetaryl-C ₁ -C4-alkyl, wherein the rings are unsubstituted or substituted with Rs and where hetaryl in hetaryl or hetaryl-C ₁ -C ₄ -alkyl, is preferably a 5- or 6-membered monocyclic hetaryl such as pyridyl, pyrimidinyl, pyridazinyl, pyr- rolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, isoxazolyl or isothiazolyl which is unsubstituted or substituted with Rs.

Examples of particularly preferred radicals R ¹¹ are the radicals R ¹¹ -1 to R ¹¹ -29 summarized in Table B below.

Table B: Examples of radicals R ¹¹

In one embodiment, R ¹² is a radical of the formula (A ¹ ),

wherein # indicates the point of attachment to T and wherein R ¹²¹ , R ¹²² , R ¹²³ and R ¹²⁴ are as defined above and wherein R ¹²¹ , R ¹²² , R ¹²³ and R ¹²⁴ independently of each other and especially in combination preferably have the following meanings:

R ¹²¹ is C ₁ -C ₄ -alkoxy, in particular OCH ₃ , OC ₂ H ₅ ;

R ¹²² is C ₁ -C ₄ -alkoxy, such as OCH ₃ , OC2H5, n-propoxyx or isopropoxy, or C ₃ -C ₄ -alkenyloxy, such as allyloxy, with R ¹²² in particular being OCH ₃ , OC2H5, or n-propoxy;

R ¹²³ is OH, C ₁ -C ₄ -alkoxy, such as OCH ₃ , OC2H5,, or C ₃ -C ₄ -alkenyloxy, such as allyloxy, with R ¹²³ in particular being OCH ₃ , OC ₂ H ₅ ;

R ¹²⁴ is C ₁ -C ₄ -alkyl, such as CH ₃ or C2H ₅ , or C ₁ -C ₄ -alkoxy-C ₁ -C ₄ -alkyl, such as methoxyme- thyl, ethoxymethyl, 2-methoxyethyl or 2-ethoxyethyl, with R ¹²⁴ in particular being methyl;.

In more preferred embodiment, R ¹² is in particular a radical of the formula (A ¹¹ ), e.g. (A ¹¹ -a) or (A ¹¹ -b)

wherein # indicates the point of attachment to T and wherein R ¹²¹ , R ¹²² , R ¹²³ and R ¹²⁴ are as defined above and wherein R ¹²¹ , R ¹²² , R ¹²³ and R ¹²⁴ independently of each other and especially in combination preferably have the following meanings:

R ¹²¹ is C ₁ -C ₄ -alkoxy, in particular OCH ₃ or OC ₂ H ₅ ;

R ¹²² is C ₁ -C ₄ -alkoxy, such as OCH ₃ , OC2H5, n-propoxyx or isopropoxy, or C ₃ -C ₄ -alkenyloxy, such as allyloxy, with R ¹²² in particular being OCH ₃ , OC2H5 or n-propoxy;

R ¹²³ is OH, C ₁ -C ₄ -alkoxy, such as OCH ₃ or OC2H5, or C ₃ -C ₄ -alkenyloxy, such as allyloxy, with R ¹²³ in particular being OCH ₃ or OC2H5;

R ¹²⁴ is C ₁ -C ₄ -alkyl, such as CH ₃ or C2H ₅ , or C ₁ -C ₄ -alkoxy-C ₁ -C ₄ -alkyl, such as methoxyme- thyl, ethoxymethyl, 2-methoxyethyl or 2-ethoxyethyl, with R ¹²⁴ in particular being methyl.

Particular examples of radicals R ¹² are the following radicals A ¹¹ -1 , A ¹¹ -1 a, A ¹¹ -1 b, A ¹¹ -2, A ¹¹ -2a, _A ¹¹ _2b, A ¹¹ -3, A ¹¹ -3a and A ¹¹ -3b:

₇ )

Particularly preferred compounds of formula I are compounds wherein,

A is N or CR ^A ;

G is N or CR ⁶ ;

Q is NH or NCH ₃

R is H or C ₁ -C ₆ -alkyl, preferably CH ₃ ;

R ^A is H or N(CH ₃ ) ₂ ;

R ^B is H or CH ₃ ;

Ar is Ar-2;

R ¹ is a moiety of formula X-Y-Z-T-R ¹¹ or X-Y-Z-T-R ¹² ; wherein X-Y-Z-T is selected from X-Y-Z- T-1 , X-Y-Z-T-2, X-Y-Z-T-3, X-Y-Z-T-4, X-Y-Z-T, X-Y-Z-T-9, X-Y-Z-T-13, X-Y-Z-T-16, X-Y-Z-T-17, X- Y-Z-T-18, and X-Y-Z-T-19;

R ¹¹ is R ¹¹ -1 or R ¹¹ -10;

R ¹² is formula A ¹¹ -1 ;

Also particularly preferred compounds of formula I are compounds of formula I. a to l.p, wherein D is R ¹¹ or R ¹² , wherein R ¹¹ is selected from R ¹¹ -1 to R ¹¹ -29, and R ¹² is selected from (A ¹¹ -1 a), (A ¹¹ - 1 b), (A ¹¹ -2a), (A ¹¹ -2b), (A ¹¹ -3a), and (A ¹¹ -3b).

wherein,

Ar is Ar ¹ , Ar ² , Ar ³ , Ar ⁴ , Ar ⁵ , Ar ⁶ , Ar ⁷ , Ar ⁸ , Ar ⁹ , Ar ¹⁰ , Ar ¹¹ , or Ar ¹² ;

Q is NH, NCH ₃ , or O;

A is N or CH;

G is N, CH, C-CH ₃ , or C-CI;

R is H, CH ₃ , and CI;

D is R ¹¹ -1 , R ¹¹ -2, R ¹¹ -3, R ¹¹ -4, R ¹¹ -5, R ¹¹ -6, R ¹¹ -7, R ¹¹ -8, R ¹¹ -9, R ¹¹ -10, R ¹¹ -1 1 , R ¹¹ -12, R ¹¹ -13, R ¹¹ - 14, R ¹¹ -15, R ¹¹ -16, R ¹¹ -17, R ¹¹ -18, R ¹¹ -19, R ¹¹ -20, R ¹¹ -21 , R ¹¹ -22, R ¹¹ -23, R ¹¹ -24, R ¹¹ -25, R ¹¹ -26, R11-27, R ¹¹ -28, R ¹¹ -29, (A ¹¹ -1 a), (A ¹¹ -1 b), (A ¹¹ -2a), (A ¹¹ -2b), (A ¹¹ -3a), or (A ¹¹ -3b);

R ^xa is H or CH ₃ ;

R ^xb is H or CH ₃ ;

R ^xc is H or CH ₃ ;

R ^ya is H or CH ₃ ;

R ^yc is H or CH ₃ ;

R ^T is H or CH _3; and

R ^e is CH ₃ or CH ₂ Ph.

Particular compounds of formula I are the compounds of the formulae I. a to l.o that are compiled in the following tables. Each of the groups mentioned for a substituent in the tables is furthermore per se, independently of the combination in which it is mentioned, a particularly preferred aspect of the substituent in question.

Table a.1. Compounds of formula I. a in which R ^xa is H, R ^xb is H, R ^ya is H, Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.2. Compounds of formula I. a in which R ^xa is H, R ^xb is H, R ^ya is H, Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.3. Compounds of formula I. a in which R ^xa is H, R ^xb is H, R ^ya is H, Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.4. Compounds of formula I. a in which R ^xa is H, R ^xb is H, R ^ya is H, Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.5. Compounds of formula I. a in which R ^xa is H, R ^xb is H, R ^ya is H, Ais CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.6. Compounds of formula I. a in which R ^xa is H, R ^xb is H, R ^ya is H, Ais N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.7. Compounds of formula I. a in which R ^xa is H, R ^xb is H, R ^ya is H, Ais CH, G is CCI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.8. Compounds of formula I. a in which R ^xa is H, R ^xb is H, R ^ya is H, Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.9. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.10. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.11. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.12. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.13. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, Ais CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.14. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, Ais N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.15. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, Ais CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.16. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.17. Compounds of formula I. a in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.18. Compounds of formula I. a in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.19. Compounds of formula I. a in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.20. Compounds of formula I. a in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.21. Compounds of formula I. a in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-C ₂ H ₅ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.22. Compounds of formula I. a in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.23. Compounds of formula I. a in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.24. Compounds of formula I. a in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.25. Compounds of formula I. a in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.26. Compounds of formula I. a in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.27. Compounds of formula I. a in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.28. Compounds of formula I. a in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.29. Compounds of formula I. a in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.30. Compounds of formula I. a in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.31. Compounds of formula I. a in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.32. Compounds of formula I. a in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.33. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.34. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.35. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.36. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.37. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is C- CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.38. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.39. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.40. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table a.41. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.42. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.43. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.44. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.45. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is C- CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.46. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is C- CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table a.47. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is C- Cl, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table a.48. Compounds of formula I. a in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.1. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is H, A is CH, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.2. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is H, A is N, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.3. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is H, A is CH, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.4. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is H, A is N, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.5. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is H, A is CH, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.6. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is H, A is N, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.7. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is H, A is CH, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.8. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is H, A is N, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.9. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.10. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.11. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.12. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.13. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.14. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.15. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.16. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.17. Compounds of formula l.b in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.18. Compounds of formula l.b in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.19. Compounds of formula l.b in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.20. Compounds of formula l.b in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.21. Compounds of formula l.b in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.22. Compounds of formula l.b in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.23. Compounds of formula l.b in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.24. Compounds of formula l.b in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.25. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.26. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.27. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.28. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.29. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.30. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.31. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.32. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.33. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.34. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.35. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.36. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.37. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is C- CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.38. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.39. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.40. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.41. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.42. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.43. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.44. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.45. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.46. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.47. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is C- CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.48. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.49. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is H, A is CH, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.50. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is H, A is N, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.51. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is H, A is CH, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.52. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is H, A is N, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.53. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is H, A is CH, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.54. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is H, A is N, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.55. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is H, A is CH, G is C-CI, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.56. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is H, A is N, G is C-CI, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.57. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.58. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.59. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.60. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.61. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Ta- ble A.

Table b.62. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.63. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is C-CI, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Ta- ble A.

Table b.64. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is C-CI, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.65. Compounds of formula l.b in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.66. Compounds of formula l.b in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.67. Compounds of formula l.b in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.68. Compounds of formula l.b in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.69. Compounds of formula l.b in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.70. Compounds of formula l.b in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.71. Compounds of formula l.b in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CI, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.72. Compounds of formula l.b in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CI, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.73. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.74. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.75. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.76. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.77. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Ta- ble A.

Table b.78. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.79. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is C-CI, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.80. Compounds of formula l.b in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is C-CI, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.81. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.82. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.83. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.84. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table b.85. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is C- CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.86. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.87. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CI, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.88. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CI, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.89. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Ta- ble A.

Table b.90. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.91. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.92. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.93. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is C- CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.94. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is C- CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.95. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is C- Cl, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table b.96. Compounds of formula l.b in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is C-CI, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Ta- ble A.

Table c.1. Compounds of formula l.c in which R ^xa is H, R ^ya is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.2. Compounds of formula l.c in which R ^xa is H, R ^ya is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.3. Compounds of formula l.c in which R ^xa is H, R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.4. Compounds of formula l.c in which R ^xa is H, R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.5. Compounds of formula l.c in which R ^xa is H, R ^ya is H, A is CH, G is C-CH ₃ , and the com- bination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.6. Compounds of formula l.c in which R ^xa is H, R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.7. Compounds of formula l.c in which R ^xa is H, R ^ya is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.8. Compounds of formula l.c in which R ^xa is H, R ^ya is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table c.9. Compounds of formula l.c in which R ^xa is CH ₃ , R ^ya is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.10. Compounds of formula l.c in which R ^xa is CH ₃ , R ^ya is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.1 1. Compounds of formula l.c in which R ^xa is CH ₃ , R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.12. Compounds of formula l.c in which R ^xa is CH ₃ , R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.13. Compounds of formula l.c in which R ^xa is CH ₃ , R ^ya is H, A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.14. Compounds of formula l.c in which R ^xa is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.15. Compounds of formula l.c in which R ^xa is CH ₃ , R ^ya is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.16. Compounds of formula l.c in which R ^xa is CH ₃ , R ^ya is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.17. Compounds of formula l.c in which R ^xa is H, R ^ya is CH ₃ , A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.18. Compounds of formula l.c in which R ^xa is H, R ^ya is CH ₃ , A is N, G is CH, and the com- bination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.19. Compounds of formula l.c in which R ^xa is H, R ^ya is CH ₃ , A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.20. Compounds of formula l.c in which R ^xa is H, R ^ya is CH ₃ , A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.21. Compounds of formula l.c in which R ^xa is H, R ^ya is CH ₃ , A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.22. Compounds of formula l.c in which R ^xa is H, R ^ya is CH ₃ , A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.23. Compounds of formula l.c in which R ^xa is H, R ^ya is CH ₃ , A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table c.24. Compounds of formula l.c in which R ^xa is H, R ^ya is CH ₃ , A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.1. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is H, R ^ya is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.2. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is H, R ^ya is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.3. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is H, R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.4. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is H, R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.5. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is H, R ^ya is H, A is CH, G is C- CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.6. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is H, R ^ya is H, Ais N, G is C- CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.7. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is H, R ^ya is H, Ais CH, G is C- CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.8. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is H, R ^ya is H, Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.9. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is H, R ^xc is H, R ^ya is H, Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table d.10. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is H, R ^xc is H, R ^ya is H, Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.11. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is H, R ^xc is H, R ^ya is H, Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.12. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is H, R ^xc is H, R ^ya is H, Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.13. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is H, R ^xc is H, R ^ya is H, Ais CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.14. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is H, R ^xc is H, R ^ya is H, Ais N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.15. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is H, R ^xc is H, R ^ya is H, Ais CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.16. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is H, R ^xc is H, R ^ya is H, Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.17. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is H, R ^ya is CH ₃ , Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.18. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is H, R ^ya is CH ₃ , Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table d.19. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is H, R ^ya is CH ₃ , Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.20. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is H, R ^ya is CH ₃ , A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.21. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is H, R ^ya is CH ₃ , Ais CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.22. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is H, R ^ya is CH ₃ , Ais N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.23. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table d.24. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is H, R ^ya is CH ₃ , A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.25. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is H, R ^ya is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table d.26. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is H, R ^ya is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.27. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is H, R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.28. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is H, R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.29. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is H, R ^ya is H, A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.30. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is H, R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.31. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is H, R ^ya is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.32. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is H, R ^ya is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.33. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is H, R ^ya is CH ₃ , A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.34. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is H, R ^ya is CH ₃ , A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.35. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is H, R ^ya is CH ₃ , A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.36. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is H, R ^ya is CH ₃ , A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.37. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is H, R ^ya is CH ₃ , A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.38. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is H, R ^ya is CH ₃ , A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.39. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is H, R ^ya is CH ₃ , A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.40. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is H, R ^ya is CH ₃ , A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.41. pounds of the formula l.d in which R ^xa is H, R ^xb is H, R ^xc is CH ₃ , R ^ya is CH ₃ , A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table d.42. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is CH ₃ , R ^ya is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.43. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is CH ₃ , R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.44. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is CH ₃ , R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.45. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is CH ₃ , R ^ya is H, A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.46. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.47. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is CH ₃ , R ^ya is H, A is CH, G is CCI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.48. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is CH ₃ , R ^ya is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.49. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is H, R ^xc is CH ₃ , R ^ya is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.50. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is H, R ^xc is CH ₃ , R ^ya is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table d.51. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is H, R ^xc is CH ₃ , R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.52. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is H, R ^xc is CH ₃ , R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.53. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is H, R ^xc is CH ₃ , R ^ya is H, A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.54. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is H, R ^xc is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.55. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is H, R ^xc is CH ₃ , R ^ya is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.56. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is H, R ^xc is CH ₃ , R ^ya is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table d.57. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is CH ₃ , R ^ya is CH ₃ , A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table d.58. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is CH ₃ , R ^ya is CH ₃ , A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.59. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is CH ₃ , R ^ya is CH ₃ , A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table d.60. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is CH ₃ , R ^ya is CH ₃ , A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.61. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is CH ₃ , R ^ya is CH ₃ , A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.62. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is CH ₃ , R ^ya is CH ₃ , A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.63. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is CH ₃ , R ^ya is CH ₃ , A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table d.64. Compounds of formula l.d in which R ^xa is H, R ^xb is H, R ^xc is CH ₃ , R ^ya is CH ₃ , A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table d.65. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is CH ₃ , R ^ya is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.66. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is CH ₃ , R ^ya is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.67. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is CH ₃ , R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.68. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is CH ₃ , R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.69. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is CH ₃ , R ^ya is H, A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.70. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.71. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is CH ₃ , R ^ya is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.72. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is CH ₃ , R ^ya is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.73. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is CH ₃ , R ^ya is CH ₃ , A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.74. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is CH ₃ , R ^ya is CH ₃ , A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.75. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is CH ₃ , R ^ya is CH ₃ , A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Ta- ble A.

Table d.76. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is CH ₃ , R ^ya is CH ₃ , A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.77. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is CH ₃ , R ^ya is CH ₃ , A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.78. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is CH ₃ , R ^ya is CH ₃ , A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.79. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is CH ₃ , R ^ya is CH ₃ , A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table d.80. Compounds of formula l.d in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^xc is CH ₃ , R ^ya is CH ₃ , A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.1. Compounds of formula l.e in which R ^xc is H, R ^ya is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.2. Compounds of formula l.e in which R ^xc is H, R ^ya is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.3. Compounds of formula l.e in which R ^xc is H, R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.4. Compounds of formula l.e in which R ^xc is H, R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.5. Compounds of formula l.e in which R ^xc is H, R ^ya is H, A is CH, G is C-CH ₃ , and the com- bination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.6. Compounds of formula l.e in which R ^xc is H, R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.7. Compounds of formula l.e in which R ^xc is H, R ^ya is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.8. Compounds of formula l.e in which R ^xc is H, R ^ya is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.9. Compounds of formula l.e in which R ^xc is CH ₃ , R ^ya is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.10. Compounds of formula l.e in which R ^xc is CH ₃ , R ^ya is H, A is N, G is CH, and the com- bination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table e.11. Compounds of formula l.e in which R ^xc is CH ₃ , R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.12. Compounds of formula l.e in which R ^xc is CH ₃ , R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.13. Compounds of formula l.e in which R ^xc is CH ₃ , R ^ya is H, A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.14. Compounds of formula l.e in which R ^xc is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.15. Compounds of formula l.e in which R ^xc is CH ₃ , R ^ya is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.16. Compounds of formula l.e in which R ^xc is CH ₃ , R ^ya is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.17. Compounds of formula l.e in which R ^xc is H, R ^ya is CH ₃ , A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.18. Compounds of formula l.e in which R ^xc is H, R ^ya is CH ₃ , A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.19. Compounds of formula l.e in which R ^xc is H, R ^ya is CH ₃ , A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.20. Compounds of formula l.e in which R ^xc is H, R ^ya is CH ₃ , A is N, G is N, and the combi- nation of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.21. Compounds of formula l.e in which R ^xc is H, R ^ya is CH ₃ , A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.22. Compounds of formula l.e in which R ^xc is H, R ^ya is CH ₃ , A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.23. Compounds of formula l.e in which R ^xc is H, R ^ya is CH ₃ , A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table e.24. Compounds of formula l.e in which R ^xc is H, R ^ya is CH ₃ , A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.1. Compounds of formula l.f in which R ^e is CH ₂ Ph, R ^ya is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.2. Compounds of formula l.f in which R ^e is CH ₂ Ph, R ^ya is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.3. Compounds of formula l.f in which R ^e Re is CH ₂ Ph, R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.4. Compounds of formula l.f in which R ^e is CH ₂ Ph, R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.5. Compounds of formula l.f in which R ^e is CH ₂ Ph, R ^ya is H, A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.6. Compounds of formula l.f in which R ^e is CH ₂ Ph, R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.7. Compounds of formula l.f in which R ^e is CH ₂ Ph, R ^ya is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.8. Compounds of formula l.f in which R ^e Re is CH ₂ Ph, R ^ya is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.9. Compounds of formula l.f in which R ^e is CH ₃ , R ^ya is H, A is CH, G is CH, and the combi- nation of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.10. Compounds of formula l.f in which R ^e is CH ₃ , R ^ya is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.1 1. Compounds of formula l.f in which R ^e is CH ₃ , R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.12. Compounds of formula l.f in which R ^e is CH ₃ , R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.13. Compounds of formula l.f in which R ^e is CH ₃ , R ^ya is H, A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.14. Compounds of formula l.f in which R ^e is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.15. Compounds of formula l.f in which R ^e is CH ₃ , R ^ya is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.16. Compounds of formula l.f in which R ^e is CH ₃ , R ^ya is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.17. Compounds of formula l.f in which R ^e is CH ₂ Ph, R ^ya is CH ₃ , A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.18. Compounds of formula l.f in which R ^e is CH ₂ Ph, R ^ya is CH ₃ , A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.19. Compounds of formula l.f in which R ^e is CH ₂ Ph, R ^ya is CH ₃ , A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.20. Compounds of formula l.f in which R ^e is CH ₂ Ph, R ^ya is CH ₃ , A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.21. Compounds of formula l.f in which R ^e is CH ₂ Ph, R ^ya is CH ₃ , A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.22. Compounds of formula l.f in which R ^e is CH ₂ Ph, R ^ya is CH ₃ , A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.23. Compounds of formula l.f in which R ^e is CH ₂ Ph, R ^ya is CH ₃ , A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table f.24. Compounds of formula l.f in which R ^e is CH ₂ Ph, R ^ya is CH ₃ , A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.1. Compounds of formula l.g in which R ^xc is H, R ^ya is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.2. Compounds of formula l.g in which R ^xc is H, R ^ya is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.3. Compounds of formula l.g in which R ^xc is H, R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table g.4. Compounds of formula l.g in which R ^xc is H, R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.5. Compounds of formula l.g in which R ^xc is H, R ^ya is H, A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.6. Compounds of formula l.g in which R ^xc is H, R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.7. Compounds of formula l.g in which R ^xc is H, R ^ya is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.8. Compounds of formula l.g in which R ^xc is H, R ^ya is H, A is N, G is C-CI, and the combi- nation of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.9. Compounds of formula l.g in which R ^xc is CH ₃ , R ^ya is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.10. Compounds of formula l.g in which R ^xc is CH ₃ , R ^ya is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.11. Compounds of formula l.g in which R ^xc is CH ₃ , R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.12. Compounds of formula l.g in which R ^xc is CH ₃ , R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.13. Compounds of formula l.g in which R ^xc is CH ₃ , R ^ya is H, A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.14. Compounds of formula l.g in which R ^xc is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.15. Compounds of formula l.g in which R ^xc is CH ₃ , R ^ya is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.16. Compounds of formula l.g in which R ^xc is CH ₃ , R ^ya is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.17. Compounds of formula l.g in which R ^xc is H, R ^ya is CH ₃ , A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.18. Compounds of formula l.g in which R ^xc is H, R ^ya is CH ₃ , A is N, G is CH, and the com- bination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.19. Compounds of formula l.g in which R ^xc is H, R ^ya is CH ₃ , A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.20. Compounds of formula l.g in which R ^xc is H, R ^ya is CH ₃ , A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.21. Compounds of formula l.g in which R ^xc is H, R ^ya is CH ₃ , A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.22. Compounds of formula l.g in which R ^xc is H, R ^ya is CH ₃ , A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.23. Compounds of formula l.g in which R ^xc is H, R ^ya is CH ₃ , A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table g.24. Compounds of formula l.g in which R ^xc is H, R ^ya is CH ₃ , A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.1. Compounds of formula l.h in which R ^xa is H, R ^xb is H, R ^yc is H, Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.2. Compounds of formula l.h in which R ^xa is H, R ^xb is H, R ^yc is H, Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.3. Compounds of formula l.h in which R ^xa is H, R ^xb is H, R ^yc is H, Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.4. Compounds of formula l.h in which R ^xa is H, R ^xb is H, R ^yc is H, Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.5. Compounds of formula l.h in which R ^xa is H, R ^xb is H, R ^yc is H, Ais CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.6. Compounds of formula l.h in which R ^xa is H, R ^xb is H, R ^yc is H, Ais N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.7. Compounds of formula l.h in which R ^xa is H, R ^xb is H, R ^yc is H, Ais CH, G is CCI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.8. Compounds of formula l.h in which R ^xa is H, R ^xb is H, R ^yc is H, Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.9. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.10. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.11. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.12. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.13. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.14. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.15. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.16. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.17. Compounds of formula l.h in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.18. Compounds of formula l.h in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.19. Compounds of formula l.h in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.20. Compounds of formula l.h in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table h.21. Compounds of formula l.h in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, A is CH, G is C-C ₂ H ₅ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.22. Compounds of formula l.h in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.23. Compounds of formula l.h in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.24. Compounds of formula l.h in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.25. Compounds of formula l.h in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.26. Compounds of formula l.h in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.27. Compounds of formula l.h in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.28. Compounds of formula l.h in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.29. Compounds of formula l.h in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.30. Compounds of formula l.h in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.31. Compounds of formula l.h in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.32. Compounds of formula l.h in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.33. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.34. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.35. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.36. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.37. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, A is CH, G is C- CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table h.38. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.39. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.40. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.41. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.42. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.43. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.44. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.45. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , A is CH, G is C- CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table h.46. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , A is N, G is C- CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.47. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , A is CH, G is C- Cl, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table h.48. Compounds of formula l.h in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.1. Compounds of formula l.i in which R ^xa is H, R ^xb is H, R ^ya is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.2. Compounds of formula l.i in which R ^xa is H, R ^xb is H, R ^ya is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.3. Compounds of formula l.i in which R ^xa is H, R ^xb is H, R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.4. Compounds of formula l.i in which R ^xa is H, R ^xb is H, R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.5. Compounds of formula l.i in which R ^xa is H, R ^xb is H, R ^ya is H, A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.6. Compounds of formula l.i in which R ^xa is H, R ^xb is H, R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.7. Compounds of formula l.i in which R ^xa is H, R ^xb is H, R ^ya is H, A is CH, G is CCI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.8. Compounds of formula l.i in which R ^xa is H, R ^xb is H, R ^ya is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.9. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.10. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.1 1. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.12. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.13. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table i.14. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.15. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.16. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.17. Compounds of formula l.i in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.18. Compounds of formula l.i in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.19. Compounds of formula l.i in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.20. Compounds of formula l.i in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.21. Compounds of formula l.i in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-C ₂ H ₅ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.22. Compounds of formula l.i in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.23. Compounds of formula l.i in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.24. Compounds of formula l.i in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.25. Compounds of formula l.i in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.26. Compounds of formula l.i in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.27. Compounds of formula l.i in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.28. Compounds of formula l.i in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.29. Compounds of formula l.i in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.30. Compounds of formula l.i in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.31. Compounds of formula l.i in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.32. Compounds of formula l.i in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.33. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.34. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.35. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.36. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.37. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.38. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.39. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.40. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.41. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.42. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.43. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.44. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.45. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is C- CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.46. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.47. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table i.48. Compounds of formula l.i in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.1. Compounds of formula l.j in which R ^xa is H, R ^xb is H, R ^yc is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.2. Compounds of formula l.j in which R ^xa is H, R ^xb is H, R ^yc is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.3. Compounds of formula l.j in which R ^xa is H, R ^xb is H, R ^yc is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.4. Compounds of formula l.j in which R ^xa is H, R ^xb is H, R ^yc is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.5. Compounds of formula l.j in which R ^xa is H, R ^xb is H, R ^yc is H, A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.6. Compounds of formula l.j in which R ^xa is H, R ^xb is H, R ^yc is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table j.7. Compounds of formula l.j in which R ^xa is H, R ^xb is H, R ^yc is H, Ais CH, G is CCI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.8. Compounds of formula l.j in which R ^xa is H, R ^xb is H, R ^yc is H, Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.9. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.10. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.11. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.12. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.13. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.14. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.15. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.16. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.17. Compounds of formula l.j in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.18. Compounds of formula l.j in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.19. Compounds of formula l.j in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.20. Compounds of formula l.j in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.21. Compounds of formula l.j in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais CH, G is C-C ₂ H ₅ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.22. Compounds of formula l.j in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.23. Compounds of formula l.j in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.24. Compounds of formula l.j in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.25. Compounds of formula l.j in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.26. Compounds of formula l.j in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.27. Compounds of formula l.j in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.28. Compounds of formula l.j in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.29. Compounds of formula l.j in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.30. Compounds of formula l.j in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.31. Compounds of formula l.j in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.32. Compounds of formula l.j in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.33. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.34. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.35. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.36. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.37. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.38. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.39. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.40. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.41. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.42. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.43. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.44. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.45. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , A is CH, G is C- CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.46. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table j.47. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table j.48. Compounds of formula l.j in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.1. Compounds of formula l.k in which R ^xa is H, R ^xb is H, R ^yc is H, Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.2. Compounds of formula l.k in which R ^xa is H, R ^xb is H, R ^yc is H, Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.3. Compounds of formula l.k in which R ^xa is H, R ^xb is H, R ^yc is H, Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.4. Compounds of formula l.k in which R ^xa is H, R ^xb is H, R ^yc is H, Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.5. Compounds of formula l.k in which R ^xa is H, R ^xb is H, R ^yc is H, Ais CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.6. Compounds of formula l.k in which R ^xa is H, R ^xb is H, R ^yc is H, Ais N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.7. Compounds of formula l.k in which R ^xa is H, R ^xb is H, R ^yc is H, Ais CH, G is CCI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.8. Compounds of formula l.k in which R ^xa is H, R ^xb is H, R ^yc is H, Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.9. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.10. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.11. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.12. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.13. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.14. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.15. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.16. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is H, R ^yc is H, Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.17. Compounds of formula l.k in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.18. Compounds of formula l.k in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.19. Compounds of formula l.k in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.20. Compounds of formula l.k in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.21. Compounds of formula l.k in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais CH, G is C- CH3CH3, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.22. Compounds of formula l.k in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.23. Compounds of formula l.k in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.24. Compounds of formula l.k in which R ^xa is H, R ^xb is CH ₃ , R ^yc is H, Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.25. Compounds of formula l.k in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.26. Compounds of formula l.k in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.27. Compounds of formula l.k in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.28. Compounds of formula l.k in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.29. Compounds of formula l.k in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , Ais CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.30. Compounds of formula l.k in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , Ais N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.31. Compounds of formula l.k in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , Ais CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.32. Compounds of formula l.k in which R ^xa is H, R ^xb is H, R ^yc is CH ₃ , Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.33. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.34. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.35. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.36. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.37. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, Ais CH, G is C- CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.38. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, Ais N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.39. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, Ais CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.40. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is H, Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.41. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.42. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.43. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.44. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.45. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , Ais CH, G is C- CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.46. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , Ais N, G is C- CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.47. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , Ais CH, G is C- CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table k.48. Compounds of formula l.k in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^yc is CH ₃ , Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.1. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is H, Ais CH, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table I.2. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is H, Ais N, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.3. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is H, Ais CH, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table I.4. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is H, Ais N, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.5. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is H, Ais CH, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.6. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is H, Ais N, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.7. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is H, Ais CH, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.8. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is H, Ais N, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.9. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, Ais CH, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.10. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, Ais N, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.11. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, Ais CH, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.12. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, Ais N, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table 1.13. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.14. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table 1.15. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.16. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.17. Compounds of formula I.I in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.18. Compounds of formula I.I in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.19. Compounds of formula I.I in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table I.20. Compounds of formula I.I in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.21. Compounds of formula I.I in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table I.22. Compounds of formula I.I in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table I.23. Compounds of formula I.I in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table I.24. Compounds of formula I.I in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table I.25. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table I.26. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table I.27. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table I.28. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table I.29. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table 1.30. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.31. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.32. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.33. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.34. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.35. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.36. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.37. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table 1.38. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.39. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table I.40. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.41. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table I.42. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is CH, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table I.43. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table I.44. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is N, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table I.45. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table I.46. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is CH ₃ , R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table I.47. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table I.48. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is C-CI, R ^T is H, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table I.49. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is H, A is CH, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table 1.50. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is H, A is N, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.51. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is H, A is CH, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.52. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is H, A is N, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.53. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is H, A is CH, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R, Q Ar and D for a compound corresponds to each line of Table A.

Table 1.54. Compounds of formu la I.I in which R ^xa is H, R ^xb is H, R ^ya is H, A is N, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R, Q Ar and D for a compound corresponds to each line of Table A.

Table 1.55. Compounds of formu la I.I in which R ^xa is H, R ^xb is H, R ^ya is H, A is CH, G is C-CI, R ^T is CH ₃ , and the combination of R, Q Ar and D for a compound corresponds to each line of Table A.

Table 1.56. Compounds of formu la I.I in which R ^xa is H, R ^xb is H, R ^ya is H, A is N, G is C-CI, R ^T is CH ₃ , and the combination of R, Q Ar and D for a compound corresponds to each line of Table A.

Table 1.57. Compounds of formu la I.I in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is CH, R ^T is CH ₃ , and the combination of R, Q Ar and D for a compound corresponds to each line of Table A. Table 1.58. Compounds of formu la I.I in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is CH, R ^T is CH ₃ , and the combination of R, Q Ar and D for a compound corresponds to each line of Table A.

Table 1.59. Compounds of formu la I.I in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is N, R ^T is CH ₃ , and the combination of R, Q Ar and D for a compound corresponds to each line of Table A.

Table 1.60. Compounds of formu la I.I in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is N, R ^T is CH ₃ , and the combination of R, Q Ar and D for a compound corresponds to each line of Table A.

Table 1.61. Compounds of formu la I.I in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.62. Compounds of formu la I.I in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R Q, Ar and D for a compound corresponds to each line of Table A. Table 1.63. Compounds of formu la I.I in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is CH, G is C-CI, R ^T is CH ₃ , and the combination of R, Q Ar and D for a compound corresponds to each line of Table A.

Table 1.64. Compounds of formu la I.I in which R ^xa is CH ₃ , R ^xb is H, R ^ya is H, A is N, G is C-CI, R ^T is CH ₃ , and the combination of R, Q Ar and D for a compound corresponds to each line of Table A.

Table 1.65. Compounds of formu la I.I in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is CH, R ^T is CH ₃ , and the combination of R, Q Ar and D for a compound corresponds to each line of Table A.

Table 1.66. Compounds of formu la I.I in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is CH, R ^T is CH ₃ , and the combination of R, Q Ar and D for a compound corresponds to each line of Table A.

Table 1.67. Compounds of formu la I.I in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is N, R ^T is CH ₃ , and the combination of R, Q Ar and D for a compound corresponds to each line of Table A. Table 1.68. Compounds of formu la I.I in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is N, R ^T is CH ₃ , and the combination of R, Q Ar and D for a compound corresponds to each line of Table A.

Table 1.69. Compounds of formu la I.I in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.70. Compounds of formu la I.I in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.71. Compounds of formu la I.I in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CI, R ^T is CH ₃ , and the combination of R, Q Ar and D for a compound corresponds to each line of Table A.

Table 1.72. Compounds of formu la I.I in which R ^xa is H, R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CI, R ^T is CH ₃ , and the combination of R, Q Ar and D for a compound corresponds to each line of Table A. Table 1.73. Compounds of formu la I.I in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is CH, R ^T is CH ₃ , and the combination of R, Q Ar and D for a compound corresponds to each line of Table A. Table 1.74. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.75. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table 1.76. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.77. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.78. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.79. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is CH, G is C-CI, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.80. Compounds of formula I.I in which R ^xa is H, R ^xb is H, R ^ya is CH ₃ , A is N, G is C-CI, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table 1.81. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.82. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.83. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.84. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.85. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Ta- ble A.

Table 1.86. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.87. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is CH, G is C-CI, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.88. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is H, A is N, G is C-CI, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.89. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.90. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is CH, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table 1.91. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table 1.92. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is N, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.93. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R^ ^a is CH ₃ , A is CH, G is C- CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.94. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is C-CH ₃ , R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table 1.95. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is CH, G is C-CI, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Ta- ble A.

Table 1.96. Compounds of formula I.I in which R ^xa is CH ₃ , R ^xb is CH ₃ , R ^ya is CH ₃ , A is N, G is C-CI, R ^T is CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.1. Compounds of formula l.m in which R ^xa is H, R ^yc is H, A is CH, G is CH, and the com- bination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.2. Compounds of formula l.m in which R ^xa is H, R ^yc is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.3. Compounds of formula l.m in which R ^xa is H, R ^yc is H, A is CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.4. Compounds of formula l.m in which R ^xa is H, R ^yc is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.5. Compounds of formula l.m in which R ^xa is H, R ^yc is H, A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.6. Compounds of formula l.m in which R ^xa is H, R ^yc is H, A is N, G is C-CH ₃ , and the com- bination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.7. Compounds of formula l.m in which R ^xa is H, R ^yc is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.8. Compounds of formula l.m in which R ^xa is H, R ^yc is H, A is N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.9. Compounds of formula l.m in which R ^xa is CH ₃ , R ^yc is H, A is CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.10. Compounds of formula l.m in which R ^xa is CH ₃ , R ^yc is H, A is N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.1 1. Compounds of formula l.m in which R ^xa is CH ₃ , R ^yc is H, A is CH, G is N, and the com- bination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.12. Compounds of formula l.m in which R ^xa is CH ₃ , R ^yc is H, A is N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.13. Compounds of formula l.m in which R ^xa is CH ₃ , R ^yc is H, A is CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.14. Compounds of formula l.m in which R ^xa is CH ₃ , R ^yc is H, A is N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table m.15. Compounds of formula l.m in which R ^xa is CH ₃ , R ^yc is H, Ais CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.16. Compounds of formula l.m in which R ^xa is CH ₃ , R ^yc is H, Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.17. Compounds of formula l.m in which R ^xa is H, R ^yc is CH ₃ , Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.18. Compounds of formula l.m in which R ^xa is H, R ^yc is CH ₃ , Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.19. Compounds of formula l.m in which R ^xa is H, R ^yc is CH ₃ , Ais CH, G is N, and the com- bination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.20. Compounds of formula l.m in which R ^xa is H, R ^yc is CH ₃ , Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.21. Compounds of formula l.m in which R ^xa is H, R ^yc is CH ₃ , Ais CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.22. Compounds of formula l.m in which R ^xa is H, R ^yc is CH ₃ , Ais N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.23. Compounds of formula l.m in which R ^xa is H, R ^yc is CH ₃ , Ais CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table m.24. Compounds of formula l.m in which R ^xa is H, R ^yc is CH ₃ , Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.1. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H, R ^ya is H, Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.2. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H, R ^ya is H, Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.3. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H, R ^ya is H, Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.4. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H, R ^ya is H, Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.5. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H, R ^ya is H, Ais CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.6. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H, R ^ya is H, Ais N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.7. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H, R ^ya is H, A is CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A. Table n.8. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H, R ^ya is H, Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.9. Compounds of formula l.n in which "1-R ^xa is CH ₃ , "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H, R ^ya is H, Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.10. Compounds of formula l.n in which "1-R ^xa is CH ₃ , "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H,

R ^ya is H, R ^ya is H, Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.11. Compounds of formula l.n in which "1-R ^xa is CH ₃ , "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H,

R ^ya is H, R ^ya is H, Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.12. Compounds of formula l.n in which "1-R ^xa is CH ₃ , "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H,

R ^ya is H, R ^ya is H, Ais N, G is N, and the combination of R, Q, Ar and D for a compound corre- sponds to each line of Table A.

Table n.13. Compounds of formula l.n in which "1-R ^xa is CH ₃ , "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H,

R ^ya is H, R ^ya is H, Ais CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.14. Compounds of formula l.n in which "1-R ^xa is CH ₃ , "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H,

R ^ya is H, R ^ya is H, Ais N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.15. Compounds of formula l.n in which "1-R ^xa is CH ₃ , "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H,

R ^ya is H, R ^ya is H, Ais CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.16. Compounds of formula l.n in which "1-R ^xa is CH ₃ , "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H,

R ^ya is H, R ^ya is H, Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.17. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa is CH ₃ , "2-R ^xb is H,

R ^ya is H, R ^ya is H, Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corre- sponds to each line of Table A.

Table n.18. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa is CH ₃ , "2-R ^xb is H,

R ^ya is H, Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.19. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa is CH ₃ , "2-R ^xb is H,

R ^ya is H, Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.20. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa isCH ₃ , "2-R ^xb is H,

R ^ya is H, Ais N, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.21. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa is CH ₃ , "2-R ^xb is H,

R ^ya is H, Ais CH, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.22. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa isCH ₃ , "2-R ^xb is H,

R ^ya is H, Ais N, G is C-CH ₃ , and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.23. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa isCH ₃ , "2-R ^xb is H,

R ^ya is H, Ais CH, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.24. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa isCH ₃ , "2-R ^xb is H,

R ^ya is H, Ais N, G is C-CI, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.25. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H, R ^ya is CH ₃ , Ais CH, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.26. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H, R ^ya is CH ₃ , Ais N, G is CH, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.

Table n.27. Compounds of formula l.n in which "1-R ^xa is H, "1-R ^xb is H, "2-R ^xa is H, "2-R ^xb is H, R ^ya is CH ₃ , Ais CH, G is N, and the combination of R, Q, Ar and D for a compound corresponds to each line of Table A.