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Title:
PGC-1α BIOSYNTHESIS PROMOTER AND SLOW-TO-FAST MUSCLE CONVERSION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2018/207741
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide drugs which are capable of promoting the biosynthesis of PGC-1α participating in energy production or inhibiting slow-to-fast muscle conversion caused by, for example, lack of exercise, and have high safety. The PGC-1α biosynthesis promoter and the slow-to-fast muscle conversion inhibitor according to the present invention are characterized by comprising a bacterium of the genus Enterococcus as an active ingredient.

Inventors:
FUJINO, Hidemi (1-1 Rokkodai-cho, Nada-ku, Kobe-sh, Hyogo 01, 〒6578501, JP)
TATEGAKI, Airo (1-8 Takasagocho Miyamaecho, Takasago-sh, Hyogo 88, 〒6768688, JP)
Application Number:
JP2018/017661
Publication Date:
November 15, 2018
Filing Date:
May 07, 2018
Export Citation:
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Assignee:
KANEKA CORPORATION (2-3-18, Nakanoshima Kita-ku, Osaka-sh, Osaka 88, 〒5308288, JP)
NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY (1-1 Rokkodai-cho, Nada-ku Kobe-sh, Hyogo 01, 〒6578501, JP)
International Classes:
A61K35/744; A23L33/135; A61K35/74; A61P21/00; A61P43/00; C12N1/20
Domestic Patent References:
WO2014021205A12014-02-06
Foreign References:
JP2007522075A2007-08-09
JP2011231022A2011-11-17
Other References:
IKEJI, TAKUYA ET AL.: "Preventive effect of intake of lactic acid bacteria strain R30 with respect to fast muscle formation of muscle fiber accompanying disuse muscle atrophy", vol. 52, February 2017 (2017-02-01)
IKEJI, T. ET AL.: "Protective effects of Enterococcus faecium strain R30 on transformation of slow to fast fiber under inactive condition", FASEB JOURNAL, vol. 32, no. 1, April 2018 (2018-04-01)
HIRAYAMA, Y. ET AL.: "Enterococcus Faecium Strain R30 Prevents Capillary Regression through Increasing Red Blood Cell Velocity in Rat Soleus Muscle under Disuse Condition", FASEB JOURNAL, vol. 30, no. 1, 2016
HIRAYAMA, Y. ET AL.: "Enterococcus faecium strain R30 prevents capillary regression under disuse condition through increasing red blood cells velocity in rat soleus muscle", ADVANCES IN EXERCISE AND SPORTS PHYSIOLOGY, vol. 22, no. 4, 2016, pages 87
ARANY, Z. ET AL.: "HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1 alpha", NATURE, vol. 451, 2008, pages 1008 - 1012, XP055563553
Attorney, Agent or Firm:
UEKI, Kyuichi et al. (Fujita-Toyobo Building 9th floor, 1-16 Dojima 2-chome, Kita-ku, Osaka-sh, Osaka 03, 〒5300003, JP)
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