Title:
PGT AND APOPTOSIS
Document Type and Number:
WIPO Patent Application WO/2000/034778
Kind Code:
A1
Abstract:
A method for screening an apoptosis inhibitor characterized by screening a candidate via an effect on PGT. A cell protecting agent containing as the active ingredient a substance which can be incorporated into cells via prostaglandin transporter (PGT); and a screening method therefor comprising measuring the uptake into cells via PGT. An apoptosis inducer containing as the active ingredient a substance having a PGT inhibitory effect; and a screening method therefor comprising measuring the ability to induce apoptosis of cells with the expression of PGT. Because of having a cell apoptosis inhibitory effect, the cell protecting agent is useful as a nerve cell apoptosis inhibitor, a nerve cell protecting agent, etc. and applicable to the prevention or treatment of nervous diseases, etc. The apoptosis inducer is useful in preventing and/or treating diseases in association with cell proliferation such as tumor, etc.
Inventors:
KAWAMURA TOORU (JP)
HORIE SATOSHI (JP)
AKIRA TOSHIAKI (JP)
NAKAMURA NORIFUMI (JP)
MARUYAMA TOMOYUKI (JP)
HAYASHI KAZUTAKA (JP)
HORIE SATOSHI (JP)
AKIRA TOSHIAKI (JP)
NAKAMURA NORIFUMI (JP)
MARUYAMA TOMOYUKI (JP)
HAYASHI KAZUTAKA (JP)
Application Number:
PCT/JP1999/006766
Publication Date:
June 15, 2000
Filing Date:
December 02, 1999
Export Citation:
Assignee:
YOSHITOMI PHARMACEUTICAL (JP)
KAWAMURA TOORU (JP)
HORIE SATOSHI (JP)
AKIRA TOSHIAKI (JP)
NAKAMURA NORIFUMI (JP)
MARUYAMA TOMOYUKI (JP)
HAYASHI KAZUTAKA (JP)
KAWAMURA TOORU (JP)
HORIE SATOSHI (JP)
AKIRA TOSHIAKI (JP)
NAKAMURA NORIFUMI (JP)
MARUYAMA TOMOYUKI (JP)
HAYASHI KAZUTAKA (JP)
International Classes:
A61K31/00; G01N33/50; G01N33/88; (IPC1-7): G01N33/50; G01N33/15; C12N15/10; A61K45/00; A61K39/395; A61K31/557; A61K48/00; A61K31/70
Foreign References:
| US5792851A | 1998-08-11 | |||
| JPH08277222A | 1996-10-22 |
Other References:
N. KANAI ET. AL.: "Identification and Characterization of a Prostaglandin Transporter", SCIENCE, vol. 268, 12 May 1995 (1995-05-12), pages 866 - 869, XP002926085
F. PICA ET.AL: "Prostaglandin E2 Induces Apoptosis in Resting Immature and Mature Human Lymphocytes: A c-Myc-Dependent and Bcl-2-Independent Associated Pathway 1", THE JOURNAL OF PHAMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 277, no. 3, 12 February 1996 (1996-02-12), ROME, pages 1793 - 1800, XP002926086
See also references of EP 1146337A4
F. PICA ET.AL: "Prostaglandin E2 Induces Apoptosis in Resting Immature and Mature Human Lymphocytes: A c-Myc-Dependent and Bcl-2-Independent Associated Pathway 1", THE JOURNAL OF PHAMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 277, no. 3, 12 February 1996 (1996-02-12), ROME, pages 1793 - 1800, XP002926086
See also references of EP 1146337A4
Attorney, Agent or Firm:
Shoji, Takashi (Iwamotocho 3-chome Chiyoda-ku, Tokyo, JP)
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