Title:
PH-RESPONSIVE MEMBRANE-RUPTURING POLYMER MATERIAL, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/001957
Kind Code:
A1
Abstract:
Provided in the present invention are a pH-responsive membrane-rupturing polymer material, a preparation method therefor, and the use thereof. The pH-responsive membrane-rupturing polymer material has a structure as represented by formula (I). The polymer material is hydrophobic and electrically neutral at a normal physiological pH, can be self-assembled into nanoparticles with PEG as a shell layer, and has weak interaction with a cell membrane; and when the pH is reduced, the polymer material can be protonized to form an amphiphilic structure consisting of a hydrophobic domain and a cationic domain, which has strong interaction with the cell membrane and has a strong membrane-rupturing activity, thereby killing tumor cells or bacteria with a high efficiency and a high selectivity.
Inventors:
XIONG MENGHUA (CN)
BAO YAN (CN)
HUANG LIANGQI (CN)
WANG XIAOCHUAN (CN)
LIU MINGDONG (CN)
LIANG YANGBIN (CN)
WANG JUN (CN)
BAO YAN (CN)
HUANG LIANGQI (CN)
WANG XIAOCHUAN (CN)
LIU MINGDONG (CN)
LIANG YANGBIN (CN)
WANG JUN (CN)
Application Number:
PCT/CN2021/102758
Publication Date:
January 06, 2022
Filing Date:
June 28, 2021
Export Citation:
Assignee:
UNIV SOUTH CHINA TECH (CN)
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV (CN)
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV (CN)
International Classes:
A61K31/785; A61K47/34; A61P35/00; C08F2/38; C08F220/34
Domestic Patent References:
| WO2020092633A1 | 2020-05-07 |
Foreign References:
| CN104650307A | 2015-05-27 | |||
| CN109265680A | 2019-01-25 | |||
| JP2019108473A | 2019-07-04 |
Other References:
JACOBSON MAX E., BECKER KYLE W., PALMER CHRISTIAN R., PASTORA LUCINDA E., FLETCHER R. BROCK, COLLINS KATHRYN A., FEDOROVA OLGA, DU: "Structural Optimization of Polymeric Carriers to Enhance the Immunostimulatory Activity of Molecularly Defined RIG-I Agonists", ACS CENTRAL SCIENCE, vol. 6, no. 11, 25 November 2020 (2020-11-25), pages 2008 - 2022, XP055883778, ISSN: 2374-7943, DOI: 10.1021/acscentsci.0c00568
XU XIAO-FEI, PAN CAI-YUAN, ZHANG WEN-JIAN, HONG CHUN-YAN: "Polymerization-Induced Self-Assembly Generating Vesicles with Adjustable pH-Responsive Release Performance", MACROMOLECULES, vol. 52, no. 5, 12 March 2019 (2019-03-12), US , pages 1965 - 1975, XP055883779, ISSN: 0024-9297, DOI: 10.1021/acs.macromol.9b00144
BALJON JESSALYN J., DANDY AAMINA, WANG-BISHOP LIHONG, WEHBE MOHAMED, JACOBSON MAX E., WILSON JOHN T.: "The efficiency of cytosolic drug delivery using pH-responsive endosomolytic polymers does not correlate with activation of the NLRP3 inflammasome", BIOMATERIALS SCIENCE, vol. 7, no. 5, 23 April 2019 (2019-04-23), GB , pages 1888 - 1897, XP055883780, ISSN: 2047-4830, DOI: 10.1039/C8BM01643G
LUO CHUNHUI, LIU YU, LI ZHIBO: "Pathway-dependent re-assembly of dual-responsive ABC terpolymer in water", SOFT MATTER, vol. 8, no. 9, 1 January 2012 (2012-01-01), GB , pages 2618 - 2626, XP055883781, ISSN: 1744-683X, DOI: 10.1039/c2sm07063d
XU XIAO-FEI, PAN CAI-YUAN, ZHANG WEN-JIAN, HONG CHUN-YAN: "Polymerization-Induced Self-Assembly Generating Vesicles with Adjustable pH-Responsive Release Performance", MACROMOLECULES, vol. 52, no. 5, 12 March 2019 (2019-03-12), US , pages 1965 - 1975, XP055883779, ISSN: 0024-9297, DOI: 10.1021/acs.macromol.9b00144
BALJON JESSALYN J., DANDY AAMINA, WANG-BISHOP LIHONG, WEHBE MOHAMED, JACOBSON MAX E., WILSON JOHN T.: "The efficiency of cytosolic drug delivery using pH-responsive endosomolytic polymers does not correlate with activation of the NLRP3 inflammasome", BIOMATERIALS SCIENCE, vol. 7, no. 5, 23 April 2019 (2019-04-23), GB , pages 1888 - 1897, XP055883780, ISSN: 2047-4830, DOI: 10.1039/C8BM01643G
LUO CHUNHUI, LIU YU, LI ZHIBO: "Pathway-dependent re-assembly of dual-responsive ABC terpolymer in water", SOFT MATTER, vol. 8, no. 9, 1 January 2012 (2012-01-01), GB , pages 2618 - 2626, XP055883781, ISSN: 1744-683X, DOI: 10.1039/c2sm07063d
Attorney, Agent or Firm:
GUANGZHOU PRIME IP LAW OFFICE (CN)
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