Title:
PH-RESPONSIVE POLYMER AND DRUG DELIVERY SYSTEM
Document Type and Number:
WIPO Patent Application WO/2018/110366
Kind Code:
A1
Abstract:
Provided is a pH-responsive polymer comprising a biocompatible polymer in which there is bonded a group that is electrically neutral under pH environments that exceed 7 and that changes to cationic at a pH of 7 or lower.
Inventors:
NISHIYAMA NOBUHIRO (JP)
TAKEMOTO HIROYASU (JP)
RANNEH ABDUL-HACKAM (JP)
TOMODA KEISHIRO (JP)
NOMOTO TAKAHIRO (JP)
MATSUI MAKOTO (JP)
TAKEMOTO HIROYASU (JP)
RANNEH ABDUL-HACKAM (JP)
TOMODA KEISHIRO (JP)
NOMOTO TAKAHIRO (JP)
MATSUI MAKOTO (JP)
Application Number:
PCT/JP2017/043604
Publication Date:
June 21, 2018
Filing Date:
December 05, 2017
Export Citation:
Assignee:
TOKYO INST TECH (JP)
International Classes:
C08G69/48; A61K47/59
Domestic Patent References:
| WO2010093036A1 | 2010-08-19 |
Foreign References:
| JP2011231220A | 2011-11-17 | |||
| JP2000086757A | 2000-03-28 | |||
| JP2016243749A | 2016-12-15 |
Other References:
IWASAKI, TAKASHI ET AL.: "Cellular uptake and in vivo distribution of polyhistidine peptides", JOURNAL OF CONTROLLED RELEASE, vol. 210, 27 July 2015 (2015-07-27), pages 115 - 124, XP029217581, ISSN: 0168-3659
TANGSANGASAKSRI, MONTIRA ET AL.: "siRNA-Loaded Polyion Complex Micelle Decorated with Charge-Conversional Polymer Tuned to Undergo Stepwise Response to Intra-Tumoral and Intra-Endosomal", BIOMACROMOLECULES, vol. 17, no. 1, 30 November 2015 (2015-11-30), pages 246 - 255, XP055495444
KNOP K. ET AL.: "Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alterations", ANGEW. CHEM. INT. ED., vol. 49, 2010, pages 6288 - 6208
See also references of EP 3556792A4
TANGSANGASAKSRI, MONTIRA ET AL.: "siRNA-Loaded Polyion Complex Micelle Decorated with Charge-Conversional Polymer Tuned to Undergo Stepwise Response to Intra-Tumoral and Intra-Endosomal", BIOMACROMOLECULES, vol. 17, no. 1, 30 November 2015 (2015-11-30), pages 246 - 255, XP055495444
KNOP K. ET AL.: "Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alterations", ANGEW. CHEM. INT. ED., vol. 49, 2010, pages 6288 - 6208
See also references of EP 3556792A4
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
Download PDF:
Previous Patent: VEHICULAR OCCUPANT DETECTION DEVICE
Next Patent: VEHICULAR OCCUPANT DETECTION DEVICE
Next Patent: VEHICULAR OCCUPANT DETECTION DEVICE