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Patent Searching and Data


Title:
PH-RESPONSIVE POLYMER AND DRUG DELIVERY SYSTEM
Document Type and Number:
WIPO Patent Application WO/2018/110366
Kind Code:
A1
Abstract:
Provided is a pH-responsive polymer comprising a biocompatible polymer in which there is bonded a group that is electrically neutral under pH environments that exceed 7 and that changes to cationic at a pH of 7 or lower.

Inventors:
NISHIYAMA Nobuhiro (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
TAKEMOTO Hiroyasu (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
RANNEH Abdul-Hackam (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
TOMODA Keishiro (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
NOMOTO Takahiro (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
MATSUI Makoto (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
Application Number:
JP2017/043604
Publication Date:
June 21, 2018
Filing Date:
December 05, 2017
Export Citation:
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Assignee:
TOKYO INSTITUTE OF TECHNOLOGY (2-12-1, Ookayama Meguro-k, Tokyo 50, 〒1528550, JP)
International Classes:
C08G69/48; A61K47/59
Domestic Patent References:
WO2010093036A12010-08-19
Foreign References:
JP2011231220A2011-11-17
JP2000086757A2000-03-28
JP2016243749A2016-12-15
Other References:
IWASAKI, TAKASHI ET AL.: "Cellular uptake and in vivo distribution of polyhistidine peptides", JOURNAL OF CONTROLLED RELEASE, vol. 210, 27 July 2015 (2015-07-27), pages 115 - 124, XP029217581, ISSN: 0168-3659
TANGSANGASAKSRI, MONTIRA ET AL.: "siRNA-Loaded Polyion Complex Micelle Decorated with Charge-Conversional Polymer Tuned to Undergo Stepwise Response to Intra-Tumoral and Intra-Endosomal", BIOMACROMOLECULES, vol. 17, no. 1, 30 November 2015 (2015-11-30), pages 246 - 255, XP055495444
KNOP K. ET AL.: "Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alterations", ANGEW. CHEM. INT. ED., vol. 49, 2010, pages 6288 - 6208
Attorney, Agent or Firm:
TANAI Sumio et al. (1-9-2, Marunouchi Chiyoda-k, Tokyo 20, 〒1006620, JP)
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