Title:
PH RESPONSIVE SELF-HEALING HYDROGELS FORMED BY BORONATE-CATECHOL COMPLEXATION
Document Type and Number:
WIPO Patent Application WO/2012/159106
Kind Code:
A3
Abstract:
Biocompatible hydrogels made from cross-linked catechol-borate ester polymers are disclosed, along with methods of synthesizing and using such hydrogels. The hydrogels of the present invention are prepared by boronic acid-catechol complexation between catechol- containing macromonomers and boronic acid-containing cross-linkers. The resulting hydrogels are pH-responsive and self-healing, and can be used in a number of different biomedical applications, including in surgical implants, in surgical adhesives, and in drug delivery systems is data provides further evidence of the viability of using the disclosed hydrogels for in vivo in biomedical applications.
Inventors:
MESSERSMITH PHILIP B (US)
HE LIHONG (US)
FULLENKAMP DOMINIC E (US)
HE LIHONG (US)
FULLENKAMP DOMINIC E (US)
Application Number:
PCT/US2012/038798
Publication Date:
August 15, 2013
Filing Date:
May 21, 2012
Export Citation:
Assignee:
UNIV NORTHWESTERN (US)
MESSERSMITH PHILIP B (US)
HE LIHONG (US)
FULLENKAMP DOMINIC E (US)
MESSERSMITH PHILIP B (US)
HE LIHONG (US)
FULLENKAMP DOMINIC E (US)
International Classes:
C08G65/328; C08G65/337
Domestic Patent References:
| WO2009062146A2 | 2009-05-14 | |||
| WO2004063388A2 | 2004-07-29 |
Foreign References:
| US20110052788A1 | 2011-03-03 | |||
| EP1431300A1 | 2004-06-23 |
Other References:
HE ET AL: "PH Responsive self-healing hydrogels formed by boronate-catechol complexation", CHEM. COMM., vol. 47, 1 June 2011 (2011-06-01), pages 7497 - 7499, XP002698764
SU ET AL: "Catechol Polymers for pH-Responsive, Targeted Drug Delivery to Cancer Cells", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, 13 July 2011 (2011-07-13), XP002698765
GUVENDIREN ET AL: "Self-assembly and adhesion of DOPA-modified methacrylic triblock hydrogels", BIOMACROMOLECULES, vol. 9, 11 March 2007 (2007-03-11), pages 122 - 128, XP002698766
LEE B.P. ET AL: "Synthesis of DOPA-modified Polyethylene glycol hydrogels", BIOMACROMOLECULES, vol. 3, 7 April 2002 (2002-04-07), pages 1038 - 1047, XP002698767
SU ET AL: "Catechol Polymers for pH-Responsive, Targeted Drug Delivery to Cancer Cells", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, 13 July 2011 (2011-07-13), XP002698765
GUVENDIREN ET AL: "Self-assembly and adhesion of DOPA-modified methacrylic triblock hydrogels", BIOMACROMOLECULES, vol. 9, 11 March 2007 (2007-03-11), pages 122 - 128, XP002698766
LEE B.P. ET AL: "Synthesis of DOPA-modified Polyethylene glycol hydrogels", BIOMACROMOLECULES, vol. 3, 7 April 2002 (2002-04-07), pages 1038 - 1047, XP002698767
Attorney, Agent or Firm:
RABE, Ann, E. (411 E. Wisconsin AvenueMilwaukee, WI, US)
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