Title:
PH-SENSITIVE BLOCK COPOLYMER CONTAINING CINNAMALDEHYDE DERIVATIVES, AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2014/058252
Kind Code:
A1
Abstract:
The present invention relates to a pH-sensitive block copolymer containing cinnamaldehyde derivatives, and to a method for preparing same. The pH-sensitive block copolymer containing cinnamaldehyde derivatives according to the present invention forms micelles to enable the cinnamaldehyde derivatives to be retained in the body for a longer period of time. The micelles may be disintegrated, and the acetal bond to which the cinnamaldehyde derivatives are connected dissociates in the slightly acid pH of the cancer tissue, which thus generate and release cinnamaldehyde derivatives. The thus-released cinnamaldehyde derivatives may act specifically on cancer cells and thus may have less toxicity on normal cells. Therefore, the cinnamaldehyde derivatives have anti-cancer effects per se, and encapsulate an anti-cancer agent as a drug carrier and deliver the anti-cancer agent to the cancer cells.
Inventors:
LEE DONG WON (KR)
KIM BYUNG KUK (KR)
LEE EUN SUN (KR)
PARK SANG A (KR)
KIM BYUNG KUK (KR)
LEE EUN SUN (KR)
PARK SANG A (KR)
Application Number:
PCT/KR2013/009072
Publication Date:
April 17, 2014
Filing Date:
October 10, 2013
Export Citation:
Assignee:
NAT UNIV CHONBUK IND COOP FOUND (KR)
International Classes:
C08G81/00; A61K9/127; A61P35/00
Other References:
JINYOUNG KO ET AL.: "Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly ((beta-amino ester) block copolymer micelles for cancer therapy", JOURNAL OF CONTROLLED RELEASE, vol. 123, 2007, pages 109 - 115
ELIZABETH R. GILLIES ET AL.: "A new approach towards acid sensitive copolymer micelles for drug delivery", CHEM. COMM., 2003, pages 1640 - 1641
JAGADIS SANKARANARAYANAN ET AL.: "Multiresponse Strategies To Modulate Burst Degradation and Release from Nanoparticles", ACSNANO, vol. 4, no. 10, 2010, pages 5930 - 5936
K. VAN BUTSELE ET AL.: "Stealth properties of poly(ethylene oxide)-based triblock copolymer micelles: A prerequisite for a pH-triggered targeting system", ACTA BIOMATERIALIA, vol. 7, 2011, pages 3700 - 3707
CARMEN SCHOLZ ET AL.: "A Novel Reactive Polymeric Micelle with Aldehyde Groups on Its Surface", MARCOMOLECULES, vol. 28, 1995, pages 7295 - 7297
ELIZABETH R. GILLIES ET AL.: "A new approach towards acid sensitive copolymer micelles for drug delivery", CHEM. COMM., 2003, pages 1640 - 1641
JAGADIS SANKARANARAYANAN ET AL.: "Multiresponse Strategies To Modulate Burst Degradation and Release from Nanoparticles", ACSNANO, vol. 4, no. 10, 2010, pages 5930 - 5936
K. VAN BUTSELE ET AL.: "Stealth properties of poly(ethylene oxide)-based triblock copolymer micelles: A prerequisite for a pH-triggered targeting system", ACTA BIOMATERIALIA, vol. 7, 2011, pages 3700 - 3707
CARMEN SCHOLZ ET AL.: "A Novel Reactive Polymeric Micelle with Aldehyde Groups on Its Surface", MARCOMOLECULES, vol. 28, 1995, pages 7295 - 7297
Attorney, Agent or Firm:
KIM, SOON WOONG (KR)
κΉμμ (KR)
κΉμμ (KR)
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