Title:
PH-SENSITIVE LIPOSOMES AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2019/045097
Kind Code:
A1
Abstract:
This method for producing pH-sensitive liposomes comprises: a step wherein a diol, a polyol having a valence of 3 or more and a liposome membrane-constituting component are mixed with each other under heating conditions, thereby preparing a mixture solution wherein the liposome membrane-constituting component is dissolved in a mixture of the diol and the polyol; a step wherein this mixture solution and an aqueous medium, which has been heated in advance, are mixed with each other and homogenized; a step wherein the homogenized aqueous medium is rapidly cooled, thereby producing liposomes; and a step wherein the produced liposomes are collected. This method according to the present invention stabilizes pH-sensitive liposomes, which have been unstable and thus hard to prepare in the past, and is thus able to prepare pH-sensitive liposomes by a simple process.
Inventors:
NAWA YASUHIKO (JP)
Application Number:
PCT/JP2018/032611
Publication Date:
March 07, 2019
Filing Date:
September 03, 2018
Export Citation:
Assignee:
ICHIMARU PHARCOS INC (JP)
International Classes:
B01J13/04; A61K8/02; A61K8/55; A61K8/63; A61K9/127
Domestic Patent References:
| WO2008143339A1 | 2008-11-27 |
Foreign References:
| JP2010209012A | 2010-09-24 |
Attorney, Agent or Firm:
MEBUKI IP LAW FIRM et al. (JP)
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