PHARMACEUTICAL AGENT THAT BINDS THE P2X7 RECEPTOR

Title:

PHARMACEUTICAL AGENT THAT BINDS THE P2X7 RECEPTOR

Document Type and Number:

WIPO Patent Application WO/2019/006074

Kind Code:

A9

Abstract:

Disclosed are P2X7 receptor ligands having the formula (I) in which R = -(CH2)n-(O-CH2CH2)m-Ol-(CH2)p-X, l= 0-1, m = 0-6, n = 2-3, p = 0-2, and X = Br, CI, F or 18F. In illustrative embodiments, R = -(CH2)n, and n = 2-3. The receptor ligands are used in methods related to conditions related to the P2X7 receptor. The non-radioligands are useful for modulating inflammation conditions associated with the P2X7 receptor. The radioligands, containing 18F, are useful for as radiotracers in imaging processes, and thus for the detection and evaluation of inflammation and therapies. Also provided are processes for preparation of these P2X7 receptor ligands.

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Inventors:

ZARRINMAYEH HAMIDEH (US)
GREEN MARK (US)

Application Number:

PCT/US2018/039923

Publication Date:

July 18, 2019

Filing Date:

June 28, 2018

Export Citation:

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Assignee:

UNIV INDIANA RES & TECH CORP (US)

International Classes:

A61K31/40; A61K31/4015; A61K31/402; C07D207/04; C07D207/18; C07D207/24

Attorney, Agent or Firm:

HENRY, Thomas, Q. et al. (US)

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