Title:
PHARMACEUTICAL COCRYSTAL AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/048299
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of pharmaceutical and chemical engineering and mainly provides a pharmaceutical cocrystal and a preparation method therefor. The pharmaceutical cocrystal is formed by ralinepag and isonicotine and has advantages of having good stability and high solubility and being suitable for preparing a pharmaceutical composition.
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Inventors:
ZHANG JIE (CN)
CHEN YONG (CN)
LUO ZHONGHUA (CN)
HUANG FANGFANG (CN)
CHEN YONG (CN)
LUO ZHONGHUA (CN)
HUANG FANGFANG (CN)
Application Number:
PCT/CN2019/100468
Publication Date:
March 12, 2020
Filing Date:
August 14, 2019
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07C271/12; A61K31/17; A61P17/00
Domestic Patent References:
| WO2009117095A1 | 2009-09-24 |
Other References:
CHEN JIA-MEI ET AL: "Application of Supramolecular Chemistry on Pharmaceutical Cocrystals", CHEMICAL JOURNAL OF CHINESE UNIVERSITIES, vol. 32, no. 9, 30 September 2011 (2011-09-30), pages 2004 - 2005, XP055690569
TRAN, T. A. ET AL: "Discovery of 2‑(((1r,4r)‑4-(((4- Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy) acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 3, 10 January 2017 (2017-01-10), pages 913 - 927, XP002781144
TRAN, T. A. ET AL: "Discovery of 2‑(((1r,4r)‑4-(((4- Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy) acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 3, 10 January 2017 (2017-01-10), pages 913 - 927, XP002781144
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