Title:
PHARMACEUTICAL COMPOSITION FOR ANTI-TUMOR IMMUNOTHERAPY
Document Type and Number:
WIPO Patent Application WO/2022/047815
Kind Code:
A1
Abstract:
Use of fucoidan in synergistic enhanced anti-tumor immunotherapy. The combination of the fucoidan and an anti-tumor immunotherapeutic agent antibody can significantly inhibit the growth of a variety of malignant tumors, and obviously enhance the anti-tumor immunotherapeutic effect of the anti-tumor immunotherapeutic agent, proving that the fucoidan can be used as a functional component to prepare drugs or medical foods for use in combination with anti-tumor immunotherapy.
Inventors:
DU HONGFANG (CN)
YU GUANGLI (CN)
LI BO (CN)
MIAO QIZHUANG (CN)
ZHAO XIA (CN)
LI GUANGSHENG (CN)
CONG DAPENG (CN)
HU TING (CN)
LV YOUJING (CN)
LI QUANCAI (CN)
YANG JUAN (CN)
YU GUANGLI (CN)
LI BO (CN)
MIAO QIZHUANG (CN)
ZHAO XIA (CN)
LI GUANGSHENG (CN)
CONG DAPENG (CN)
HU TING (CN)
LV YOUJING (CN)
LI QUANCAI (CN)
YANG JUAN (CN)
Application Number:
PCT/CN2020/114195
Publication Date:
March 10, 2022
Filing Date:
September 09, 2020
Export Citation:
Assignee:
WEIHAI RESHENG PHARMACEUTICAL GROUP CO LTD (CN)
QINGDAO MARINE BIOMEDICAL RES INSTITUTE CO LTD (CN)
QINGDAO MARINE BIOMEDICAL RES INSTITUTE CO LTD (CN)
International Classes:
A61K45/06; A61K31/737; A61K39/395; A61K47/26; A61P35/00
Domestic Patent References:
| WO2019075449A1 | 2019-04-18 |
Foreign References:
| CN108785668A | 2018-11-13 | |||
| CN103880975A | 2014-06-25 | |||
| CN108289903A | 2018-07-17 |
Other References:
CHIANG, CHIH-SHENG ET AL. .: "Combination of fucoidan-based magnetic nanoparticles and immunomodulators enhances tumour-localized immunotherapy.", NATURE NANOTECHNOLOGY., vol. 13, 14 May 2018 (2018-05-14), XP036928118, DOI: 10.1038/s41565-018-0146-7
A. CUMASHI, N. A. USHAKOVA, M. E. PREOBRAZHENSKAYA, A. D'INCECCO, A. PICCOLI, L. TOTANI, N. TINARI, G. E. MOROZEVICH, A. E. BERMAN: "A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds", GLYCOBIOLOGY, OXFORD UNIVERSITY PRESS, vol. 17, no. 5, 1 January 2006 (2006-01-01), pages 541 - 552, XP055046951, ISSN: 09596658, DOI: 10.1093/glycob/cwm014
WEI WANG, JIANDONG WU, XIAOSHUANG ZHANG, CUI HAO, XIAOLIANG ZHAO, GUANGLING JIAO, XINDI SHAN, WENJING TAI, GUANGLI YU: "Inhibition of Influenza A Virus Infection by Fucoidan Targeting Viral Neuraminidase and Cellular EGFR Pathway", SCIENTIFIC REPORTS, vol. 7, no. 1, 1 February 2017 (2017-02-01), XP055754611, DOI: 10.1038/srep40760
JIAO, GUANGLING ET AL. .: "Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae.", MARINE DRUGS, vol. 9, 8 February 2011 (2011-02-08), XP002693840, DOI: 10.3390/md9020196
XU, BO HU, SHULIANG SONG, HAO LIANG, AIGUO JI: "Research progress of fucoidan in anti-tumor mechanism", CHEMISTRY OF LIFE, vol. 39, no. 5, 31 December 2019 (2019-12-31), pages 998 - 1003, XP055907082, DOI: 10.13488/j.smhx.20190069
A. CUMASHI, N. A. USHAKOVA, M. E. PREOBRAZHENSKAYA, A. D'INCECCO, A. PICCOLI, L. TOTANI, N. TINARI, G. E. MOROZEVICH, A. E. BERMAN: "A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds", GLYCOBIOLOGY, OXFORD UNIVERSITY PRESS, vol. 17, no. 5, 1 January 2006 (2006-01-01), pages 541 - 552, XP055046951, ISSN: 09596658, DOI: 10.1093/glycob/cwm014
WEI WANG, JIANDONG WU, XIAOSHUANG ZHANG, CUI HAO, XIAOLIANG ZHAO, GUANGLING JIAO, XINDI SHAN, WENJING TAI, GUANGLI YU: "Inhibition of Influenza A Virus Infection by Fucoidan Targeting Viral Neuraminidase and Cellular EGFR Pathway", SCIENTIFIC REPORTS, vol. 7, no. 1, 1 February 2017 (2017-02-01), XP055754611, DOI: 10.1038/srep40760
JIAO, GUANGLING ET AL. .: "Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae.", MARINE DRUGS, vol. 9, 8 February 2011 (2011-02-08), XP002693840, DOI: 10.3390/md9020196
XU, BO HU, SHULIANG SONG, HAO LIANG, AIGUO JI: "Research progress of fucoidan in anti-tumor mechanism", CHEMISTRY OF LIFE, vol. 39, no. 5, 31 December 2019 (2019-12-31), pages 998 - 1003, XP055907082, DOI: 10.13488/j.smhx.20190069
Attorney, Agent or Firm:
XIANGHE IP LAW FIRM (CN)
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