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Title:
PHARMACEUTICAL COMPOSITION, COMPRISING AGMATINE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, FOR PREVENTION OR TREATMENT OF FRAGILE X SYNDROME
Document Type and Number:
WIPO Patent Application WO/2019/203509
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for prevention or treatment of (psycho)neurologic abnormal behaviors such as bias toward detail-focused processing, cognitive impairment, difficulties with social interaction and communication, hyperactivity, and repetitive behavior, the composition comprising agmatine or a pharmaceutically acceptable salt thereof.

Inventors:
SHIN, Chan Young (#515-508, 350 Mokdongdong-ro,,Yangcheon-gu, Seoul, 07987, KR)
JEON, Se Jin (#105-103, 23 Dangsan-ro 41-gil,,Yeongdeungpo-gu, Seoul, 07217, KR)
KIM, Hee Jin (#515-508, 350 Mokdongdong-ro,,Yangcheon-gu, Seoul, 07987, KR)
JOO, So Hyun (#1110-1005, 25 Dongil-ro 227-gil,,Nowon-gu, Seoul, 01619, KR)
Application Number:
KR2019/004439
Publication Date:
October 24, 2019
Filing Date:
April 12, 2019
Export Citation:
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Assignee:
KONKUK UNIVERSITY GLOCAL INDUSTRY-ACADEMIC COLLABORATION FOUNDATION (268 Chungwon-daero, Chungju-si, Chungcheongbuk-do, 27478, KR)
UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY (1732, Deogyeong-daero,Giheung-gu, Yongin-si, Gyeonggi-do, 17104, KR)
NEUROVENTI (#701, 120 Neungdong-ro,,Gwangjin-gu, Seoul, 05029, KR)
International Classes:
A61K31/155; A23L33/10; A61P25/00
Foreign References:
KR101497932B12015-03-03
US20020065323A12002-05-30
KR20160078956A2016-07-05
Other References:
KIM, J. W.: "Agmatine rescues autistic behaviors in the valproic acid- induced animal model of autism", NEUROPHARMACOLOGY, vol. 113, 2017, pages 71 - 81, XP029832506, DOI: 10.1016/j.neuropharm.2016.09.014
ESNAFOGLU, E.: "Decreased plasma agmatine levels in autistic subjects", JOURNAL OF NEURAL TRANSMISSION, vol. 125, 4 January 2018 (2018-01-04), pages 735 - 740, XP036458279, DOI: 10.1007/s00702-017-1836-2
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (3rd Floor, 108 Sapyeong-daero,,Seocho-gu, Seoul, 06575, KR)
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