Title:
PHARMACEUTICAL COMPOSITION COMPRISING ARAZYME AS EFFECTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE
Document Type and Number:
WIPO Patent Application WO/2018/066969
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition comprising arazyme as an effective ingredient for prevention or treatment of metabolic diseases. In detail, arazyme produced by Aranicola proteolyticus is found to reduce levels of glycated hemoglobin (HbA1c), total cholesterol, triglyceride, and non-esterified fatty acid (NEFA) in mouse plasma, improve glucose tolerance in a high-fat diet-fed animal model under a glucose load, stimulate insulin release and synthesis in pancreatic beta cells, alleviate insulin resistance in hepatic cells, and suppress lipid accumulation and hepatic fibrosis. Therefore, the arazyme of the present invention can be effectively used in a composition for prevention or treatment of metabolic diseases.
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Inventors:
PARK HO-YONG (KR)
JEONG TAE-SOOK (KR)
SHIN DONG-HA (KR)
JEONG TAE-SOOK (KR)
SHIN DONG-HA (KR)
Application Number:
PCT/KR2017/011095
Publication Date:
April 12, 2018
Filing Date:
October 02, 2017
Export Citation:
Assignee:
INSECT BIOTECH CO LTD (KR)
International Classes:
A61K38/48; A23L33/18
Foreign References:
| KR100836711B1 | 2008-06-10 | |||
| JP2010514752A | 2010-05-06 | |||
| KR100909998B1 | 2009-07-29 | |||
| KR100945960B1 | 2010-03-05 | |||
| KR101476399B1 | 2014-12-24 |
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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