PHARMACEUTICAL COMPOSITION COMPRISING FUCOSTEROL, AS ACTIVE INGREDIENT, FOR PREVENTING OR TREATING NEURODEGENERATIVE DISEASES

WIPO Patent Application WO/2014/098512

A1

The present invention relates to a novel use of fucosterol for the treatment of neurodegenerative diseases, and more particularly, to a pharmaceutical composition and functional health food comprising fucosterol, as an active ingredient, for preventing or treating neurodegenerative diseases. The fucosterol of the present invention may effectively increase the expression of ADAM10 which is α-secretase. Therefore, the composition of the present invention comprising the fucosterol, as an active ingredient, has excellent effects of inhibiting an amyloid beta (Aβ) peptide production, and thus can be effectively used in pharmaceutical drugs, functional food, and the like for preventing or treating (alleviating) neurodegenerative diseases such as Alzheimer's disease. Particularly, the fucosterol of the present invention is derived from a natural substance, is free of cytotoxicity, and has stability. Therefore, the composition of the present invention comprising the fucosterol, as an active ingredient, has advantages of being safe for long-term use without causing side effects to the human body.

CHOI JAE-SUE (KR)
JUNG HYUN-AH (KR)
JUNG CHA-GYUN (KR)

PCT/KR2013/011924

June 26, 2014

December 20, 2013

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NAT UNIV PUKYONG IND UNIV COOP (KR)

A61K31/56; A61K36/28; A61P25/00; A61P25/28

KR20060052792A	2006-05-19
KR100518179B1	2005-09-29
KR20050076104A	2005-07-26

NY YOON ET AL., FISHERIES SCIENCE, vol. 74, 2008, pages 200 - 207
L. CUSTODIO ET AL., FOOD CHEMISTRY, vol. 131, August 2011 (2011-08-01), pages 134 - 140

KIM, TAE SUN (KR)
김태선 (KR)

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