Title:
PHARMACEUTICAL COMPOSITION COMPRISING JNK ACTIVITY INHIBITOR AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING DEGENERATIVE NEUROLOGICAL DISEASES
Document Type and Number:
WIPO Patent Application WO/2019/088395
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition comprising a JNK activity inhibitor as an active ingredient for preventing or treating degenerative neurological diseases, wherein the composition may inhibit the activity of c-Jun kinases and reduce the inflammatory response and beta amyloid production of neuronal cells.
Inventors:
KIM MYEONG OK (KR)
Application Number:
PCT/KR2018/007287
Publication Date:
May 09, 2019
Filing Date:
June 27, 2018
Export Citation:
Assignee:
NAT UNIV GYEONGSANG IACF (KR)
International Classes:
A61K31/416; A23L33/10
Other References:
YESTE-VELASCO, M. ET AL.: "Neuroprotection by C-Jun NH2-terminal Kinase Inhibitor SP600 125 against Potassium Deprivation-induced Apoptosis Involves the Akt Pathway and Inhibition of Cell Cycle Reentry", NEUROSCIENCE, vol. 159, 2009, pages 1135 - 1147, XP026933820, doi:10.1016/j.neuroscience.2009.01.035
CHEN, X. ET AL.: "The C-Jun N-terminal Kinase Inhibitor SP600125 Is Neuroprotective in Amygdala Kindled Rats", BRAIN RESEARCH, vol. 1357, 2010, pages 104 - 114
AMBHORE, N. S. ET AL.: "Pharmacokinetic and Tissue Distribution Studies of 1,9-pyrazoloanthrone, a C-Jun-N-terminal Kinase Inhibitor in Wistarrats by a Simple and Sensitive HPLC Method", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 120, 2016, pages 57 - 64, XP029406917, doi:10.1016/j.jpba.2015.12.004
PRASAD, K. D. ET AL.: "Alkyl Chain Substituted 1,9-pyrazoloanthrones Exhibit Prominent Inhibitory Effect on C-Jun N-terminal Kinase (JNK", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 12, no. 26, 2014, pages 4656 - 4662, XP055617922, DOI: 10.1039/C4OB00548A
UR REHMAN, S. ET AL.: "Inhibition of C-Jun N-terminal Kinase Protects against Brain Damage and Improves Learning and Memory after Traumatic Brain Injury in Adult Mice", CEREBRAL CORTEX, vol. 28, no. 8, 30 June 2017 (2017-06-30), pages 2854 - 2872, XP055617933, DOI: 10.1093/cercor/bhx164
CHEN, X. ET AL.: "The C-Jun N-terminal Kinase Inhibitor SP600125 Is Neuroprotective in Amygdala Kindled Rats", BRAIN RESEARCH, vol. 1357, 2010, pages 104 - 114
AMBHORE, N. S. ET AL.: "Pharmacokinetic and Tissue Distribution Studies of 1,9-pyrazoloanthrone, a C-Jun-N-terminal Kinase Inhibitor in Wistarrats by a Simple and Sensitive HPLC Method", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 120, 2016, pages 57 - 64, XP029406917, doi:10.1016/j.jpba.2015.12.004
PRASAD, K. D. ET AL.: "Alkyl Chain Substituted 1,9-pyrazoloanthrones Exhibit Prominent Inhibitory Effect on C-Jun N-terminal Kinase (JNK", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 12, no. 26, 2014, pages 4656 - 4662, XP055617922, DOI: 10.1039/C4OB00548A
UR REHMAN, S. ET AL.: "Inhibition of C-Jun N-terminal Kinase Protects against Brain Damage and Improves Learning and Memory after Traumatic Brain Injury in Adult Mice", CEREBRAL CORTEX, vol. 28, no. 8, 30 June 2017 (2017-06-30), pages 2854 - 2872, XP055617933, DOI: 10.1093/cercor/bhx164
Attorney, Agent or Firm:
PCR INTELLECTUAL PROPERTY LAW FIRM (KR)
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