PHARMACEUTICAL COMPOSITION COMPRISING MUTANT HUMAN GROWTH HORMONE PROTEIN OR TRANSFERRIN FUSION PROTEIN THEREOF AS EFFECTIVE INGREDIENT

Title:

PHARMACEUTICAL COMPOSITION COMPRISING MUTANT HUMAN GROWTH HORMONE PROTEIN OR TRANSFERRIN FUSION PROTEIN THEREOF AS EFFECTIVE INGREDIENT

Document Type and Number:

WIPO Patent Application WO/2018/004294

Kind Code:

A2

Abstract:

A mutant human growth hormone protein having an amino acid sequence in which serine residues at positions 85 and 144 of the amino acid sequence of human growth hormone protein are substituted by respective hydrophobic amino acids, or a transferrin fusion protein thereof according to the present invention exhibiting the effect of remarkably increasing in specific activity and blood stability and improving in half-life, compared to a conventional human growth hormone protein, and thus can be useful for the therapy of growth failure or growth retardation.

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Inventors:

YOON JEONG-HYEOK (KR)
CHANG BYUNG-HA (KR)
KIM SOON NAM (KR)
JEONG IN-HYE (KR)
PARK KYEONG SU (KR)
NAM KY-YOUB (KR)

Application Number:

PCT/KR2017/006953

Publication Date:

January 04, 2018

Filing Date:

June 30, 2017

Export Citation:

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Assignee:

CREAPLANET CO LTD (KR)

International Classes:

C07K14/61; A61K38/22; C07K14/79

Attorney, Agent or Firm:

HONESTY & JR PARTNERS INTELLECTUAL PROPERTY LAW GROUP (KR)

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