PHARMACEUTICAL COMPOSITION COMPRISING PIPERAZINE DITHIOCTATE AND GLIMEPIRIDE

WIPO Patent Application WO/2011/152658

A3

The present invention relates to a pharmaceutical composition for treating or preventing type II diabetes mellitus comprising piperazine dithioctate and glimepiride, which is a new combination drug. The pharmaceutical composition of the present invention has strong synergistic effects for treating type II diabetes mellitus by improving metabolic disorders and insulin resistance of diabetic patients as well as lowering blood glucose levels, and by increasing glucose uptake in cells, compared with single treatment of piperazine dithioctate or glimepiride, or combination treatment of thioctic acid and glimepiride.

KIM KYOUNG SOO (KR)
SHIN DONG SEONG (KR)
KWON HYUK JIN (KR)
PARK YOUNG JUN (KR)
CHO KYOUNG-SUK (KR)
YU KEEWON (KR)
LEE IN SUK (KR)
NOH JIN-HYOUNG (KR)
SONG HYUN-NAM (KR)
KIM DONG YOUN (KR)
KIM JOON WOO (KR)

PCT/KR2011/004004

April 26, 2012

June 01, 2011

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CELLTRION CHEMICAL RES INST (KR)
CELLTRION PHARM INC (KR)
KIM KYOUNG SOO (KR)
SHIN DONG SEONG (KR)
KWON HYUK JIN (KR)
PARK YOUNG JUN (KR)
CHO KYOUNG-SUK (KR)
YU KEEWON (KR)
LEE IN SUK (KR)
NOH JIN-HYOUNG (KR)
SONG HYUN-NAM (KR)
KIM DONG YOUN (KR)
KIM JOON WOO (KR)

A61K31/495; A61K31/40; A61P3/10; C07D295/027; C07D339/02

KR20060006469A	2006-01-19
KR100935554B1	2010-01-07
JPH07206676A	1995-08-08

"Alpha-lipoic acid.", ALTERNATIVE MEDICINE REVIEW, vol. 11, no. 3, 2006, pages 232 - 237

YU, Su Mi (Eunseong Bldg.601-18 Yeoksam-dong, Gangnam-gu, Seoul 135-080, KR)

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